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Fundamentals

The School of Medicine Creates System to Connect Core Services for Research

Core facilities play a fundamental role in supporting cutting-edge research by providing resources ranging from genome sequencing tools to biostatistics services. iLabs, a web-based resource, connects core facilities throughout Johns Hopkins, and the Core Coins program provides a new funding mechanism that promotes access to core facilities and innovative research.

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Precision Immunotherapy

Developed from 30 years of basic research at Johns Hopkins and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, an immunotherapy drug has now been FDA approved for cancer based on disease genetics rather than type. Bert Vogelstein and Dung Le describe this research milestone.  
 

King-Wai Yau

King-Wai Yau on Night Vision That’s Not “on the Brain”

King-Wai Yau, professor of neuroscience and ophthalmology, investigates sight and smell. He is currently studying how nocturnalnon-primate animals make their pupils constrict without using their brain. 

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Highlights

mice illustration

Drunk Mice Experience Changes in Their Epigenome

These changes may explain at least some of the differences in how cholesterol is processed in people who drink alcohol, or may affect those taking a new class of drugs designed to reduce LDL cholesterol. 

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mice

‘Bipolar’ Mice Help Researchers Understand the Biology of the Disorder

Genetically engineered mice displayed many of the behavioral hallmarks of human bipolar disorder. Behavior was reversed using well-established drug treatments. 

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3D printer illustration

3-D Printing Models of Human Organs

A cardiac surgeon and a graduate student collaborated to solve a peculiar puzzle: Could they produce a three-dimensional model of a baby’s heart?

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Fruit fly muscle

Fruit Fly Muscles Solve the mystery of Hypertrophic Cardiomyopathy

An inherited heart muscle disorder now mimicked in fruit flies helped researchers find the molecular flaw in hypertrophic cardiomyopathy. 

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DNA

Links Uncovered Between Genes and Body Tissues

The results could help show how individual genetic differences contribute to disease and could guide treatments for heritable disorders such as Alzheimer’s disease, high cholesterol or Type 1 diabetes. 

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