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Discoveries for a Better Tomorrow

Cell Biology

Ubiquitin Signals - Cynthia Wolberger, Ph.D.

Dr. Cynthia Wolberger and her team study how a protein called ubiquitin switches genes on and off and notifies the cell about DNA damage. Their work is providing clues for how scientists might develop new drugs for cancers with faulty ubiquitin signaling, and for which there are currently no effective treatments.

Learn more about Dr. Wolberger's work.

When Cell Division Goes Wrong—Dr. Andrew Holland

Glitches in cell division can lead to diseases such as Down syndrome and cancer. Dr. Andrew Holland investigates errors in cell division to identify causes of human disease.

Learn more about Dr. Holland's work.

Improving Therapy for Muscle Degenerative Diseases—Dr. Elizabeth Chen

Studies of cell fusion yield insights about immunodeficiency, infertility and pathological muscle weakness. Ultimately, Dr. Elizabeth Chen’s team hopes to use these insights to improve cell-based therapy for muscle degenerative diseases.

Cell Movement and Health—Dr. Peter Devreotes

When cell migration goes awry, it can compromise the immune system, particularly in individuals with cancer. Understanding the biochemical networks that enable cell movement can pave the way to therapies targeting cell migration, illuminating new treatments for disease.

Learn more about Dr. Devreotes' work

From Dysfunctional Cells to Disease - Dr. Rong Li

Dr. Li and her team investigate how cells consolidate their damaged proteins and prevent them from spreading freely, in order to understand how to better treat diseases such as Alzheimer’s and ALS. Another of their interests is how chromosomes are divided up when one cell becomes two. Learning more about how the process can go wrong could lend insight into cancer development.

Learn more about Dr. Li's work.

Controlling the Balance Between Salt and Water - Dr. William Guggino

Imbalances of salt and water in the body can lead to problems ranging from cystic fibrosis to diarrhea to kidney failure. Dr. Guggino and his team study the channels that move salt and water– and what goes wrong with them in disease.

Learn more about Dr. Guggino's work.

How Odor Sensitive Cells Regenerate – Randall Reed, Ph.D.

Odor-sensitive cells can warn of us of dangers and let us know when something is pleasant to eat. However, because they are so sensitive, they can easily die when exposed to the outside world. Dr. Reed’s lab seeks to understand how they can regenerate so quickly. This will prevent people from losing their sense of smell in a time of danger.

Learn more about Dr. Reed's work.

Bacteria and Antibiotics – Erin D. Goley, Ph.D

Erin Goley, Ph.D., and her lab are discovering the molecule and mechanism that bacteria use to grow, divide and to become resistant to antibiotic treatment.

Learn more about Dr. Goley's work.

Understanding the Purpose of Bacterial Cells within Your Body – Jie Xiao, Ph.D.

Jie Xiao, Ph.D., and her team study how bacterial cells divide and control which proteins they make.

Learn more about Dr. Xiao's work.