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Todd McNutt, PhD

Interests: Intensity-modulated radiotherapy treatment planning; Informatics; Image-guided radiotherapy; Radiation dose computation

Titles: Associate Professor of Radiation Oncology Physics; Director of Clinical Informatics

Schools\degrees: University of Wisconsin at Madison\PhD, Medical Physics; University of Colorado at Boulder\BA, Physics

Training: University of Wisconsin\ Resident Medical Physicist; Philips Healthcare, Radiation Oncology Systems\Director of Research and Advance Development

Clinical interests: The use of prior clinical patient data for improving the quality of care for new patients undergoing radiation therapy

Research summary: My primary research goal is to create a medical environment that allows us to measure how well we perform clinically for our patients.  This requires incorporating medical IT infrastructure into the clinical setting and using it to measure the patient experience and quantify it for analysis and trending and feedback.  In the last five years I have spent a great deal of effort integrating structured data collection into the clinical environment.  This involves establishing workflows and user and software interfaces that enable the clinician to interact with the patients with minimal interaction with the computer.  The primary focus of the work is to establish a database that allows efficient access to clinical data to look at toxicity and outcome trends and how they correlate with delivered radiation dosimetry.  We have also built a shape relationship-based model of patient similarity that allows us to look at prior radiation oncology patient treatment plans to determine the expected plan quality of a new patient.  This model is shared with the broader EMR database model in that we used a database of prior experience to guide the treatment course for new patients.  In addition, I have worked to accelerate the treatment planning process by automating planning techniques and developing a GPU-based dose computation algorithm for external beam radiation therapy. 

Prior to this recent experience, I spent eight years as director of research and advance development for the Philips Pinnacle radiation therapy planning system.  This industrial work was done in a commercial software development environment following the FDA quality system regulations for medical device manufacturing and taught me best practices in software development and design to meet customer and user interface requirements.

Journal citations

T.R. McNutt, T.R. Mackie, P.J. Reckwerdt, N. Papanikolaou, B.R. Paliwal, “Calculation of portal dose using the convolution/superposition method,” Med. Phys. 1996; 23-24.

T.R. Mackie, P.J. Reckwerdt, T.R. McNutt, M. Gehring, C. Sanders, “Photon Dose Computations,” Teletherapy: Proceedings of the 1996 AAPM Summer School.Ed. Palta J., Mackie T., AAPM-College Park MD 1996; 103-133.

T.R. McNutt, T.R. Mackie, Paul Reckwerdt, and Bhudatt R. Paliwal, “Modeling Dose Distributions from Portal Dose Images using the Convolution/Superposition Method,” Med. Phys. 1996; 23-28.

Bhudatt R. Paliwal, Mehran Zaini, Todd McNutt, E. Jeffrey Fairbanks, and Rebecca Kitchen, “A consistency monitor for radiation therapy treatments,” Med. Phys. 1996; 23-10.

T.R. McNutt, T.R. Mackie and B.R. Paliwal, “Analysis and convergence of the iterative convolution/superposition dose reconstruction technique for multiple treatment beams and tomotherapy,” Med. Phys. 1997; 24-9:1465-1476.

T.R. Mackie, et.al., including T.R. McNutt, “Tomotherapy: Rethinking the Process of Radiotherapy,” XII International Conference on the Use of Computers in Radiation Therapy, Dennis D. Leavitt and George Starkschall, Eds., Madison,  WI, 1997, ICCR, pp. 329-331, Medical Physics Publishing 1997.

P.J. Reckwerdt, T.R. Mackie, J. Balog, T.R. McNutt, “Three Dimensional Inverse Treatment Optimization for Tomotherapy,” XII International Conference on the Use of Computers in Radiation Therapy, Dennis D. Leavitt and George Starkschall, Eds., Madison,  WI, 1997, ICCR, pp. 420-422, Medical Physics Publishing 1997.

T.R. McNutt, T.R. Mackie, P.J. Reckwerdt, B.R. Paliwal, “Applications and Implementation of the iterative convolution/superposition dose reconstruction technique,” XII International Conference on the Use of Computers in Radiation Therapy, Dennis D. Leavitt and George Starkschall, Eds., Madison,  WI, 1997, ICCR, pp. 110--112, Medical Physics Publishing 1997.

B.R. Paliwal, M.A. Ritter, T.R. McNutt, T.R. Mackie, B.R. Thomadsen, J.A. Purdy, T.J. Kinsella, “A Solid water pelvic and prostate phantom for imaging, volume rendering, treatment planning and dosimetry for an RTOG multi institutional, 3-D dose escalation study,” Int’l. J. Rad. Onc. Bio. Phys. 1998; Vol. 42, No. 1 pp.205-211.

T.R. Mackie, J. Balog, K. Ruchala, D. Shepard, S. Aldridge, E., Fitchard, P. Reckwerdt, G. Olivera, T. McNutt, M. Mehta, “Tomotherapy”, Seminar Radiat Oncol. 1999 Jan; 9(1): 108-117.

B. Thomadsen, L. DeWerd, T.R. McNutt, S. DeWard, D. Schmidt, “Assessment of the strength of individual Ir192 seeds in ribbons”, Med. Phys. 26-11, 1999; pp.2471-2475.

W.A. Tome’, S.L. Meeks, T.R. McNutt, J.M. Buatti, F.J. Bova, W.A. Friedman, M. Mehta, “Optically guided intensity modulated radiotherapy:, Radiother Oncol. 2001; 61(1):33-44.

T.R. McNutt, W.A. Tome’, “A method of scaling the 3-dimensional electron pencil beam dose calculation to obtain accurate monitor units for irregularly shaped electron beams.” Medical Dosimetry. 2002; 27(3): 209-213.

H.A. Jaradat, W.A. Tome’, T.R. McNutt, M.E. Meyerand, “On the incorporation of multi-modality image registration into the radiotherapy planning process”, Technology in Cancer Research & Treatment, 2003; 2(1):1-12

S.L. Richardson, W.A. Tome’, N.P. Orton, T.R. McNutt, B.R. Paliwal, “IMRT delivery verification using a spiral phantom,” Med. Phys. 2003; 30(9):2553-8.

V. Pekar, T.R. McNutt, M.R. Kaus, “Automated Model-based Organ Delineation for Radiation Therapy Planning in the Prostate Region,” Int’l. J. Rad. Onc. Bio. Phys. 2004; 60(3):973-80.

T. Zhang, W. Lu, G.H. Olivera, T.R. McNutt, T.R. Mackie, B.R. Paliwal, “Treatment Plan Optimization Incorporating Respiratory Motion”, Med. Phys. 2004; 31(6):1576-86.

M.R. Kaus, T.R. McNutt, V. Pekar, “Automated 3D and 4D organ delineation for radiation therapy planning in the pelvic area”, Proc. of  SPIE Medical Imaging, vol.  5370, 346-356; 2004

M.R. Kaus, T. Netsch, S. Kabus V. Pekar, T. McNutt, and B. Fischer,  “Estimation of Organ Motion from 4D CT for 4D Radiation Therapy Planning of  Lung Cancer,” Proceedings of MICCAI 2004, C. Barillot, D.R. Haynor, and P. Hellier (Eds.): MICCAI 2004, LNCS 3217, pp. 1017–1024, 2004. Springer-Verlag Berlin Heidelberg

D. Ragan, G. Starkschall, T. McNutt, M. Kaus, “Semiautomated four-dimensional computed tomography segmentation using deformable models,” Med Phys 32(6). 1900; 2005

P. Cadman, T.R. McNutt, K. Bzdusek, ”Validation of physics improvements for IMRT with a commercial treatment planning system,” J. of Appl. Clinical Med. Phys. 2005

T. McNutt, M. Kaus, L, Spies; “Advances in External Beam Radiation Therapy”, Chapter 13: Advances in Healthcare Technology Shaping the Future of Medical Care; Philips Research Book Series, Vol. 6 Spekowius, Gerhard; Wendler, Thomas (Eds.)

Kim Y., Tome’ W., Bal M., McNutt T., Spies L., “The impact of dental metal artifacts on head and neck IMRT dose distributions”, Radiother Oncol. 2006 May; 79(2):198-202

Deng H, Kennedy CW, Armour E, Tryggestad E, Ford E, McNutt T, Jiang L, Wong J ,,”The Small-Animal Radiation Research Platform (SARRP): dosimetry of a focused lens system,”  Phys. Med. Biol. 52 (2007) 2729-2740.

Wong J, Armour E, Kazanzides P, Iordachita I, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu Z, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese TL, “High resolution small animal radiation research platform with x-ray tomographic guidance capabilities”, Int J Radiat Oncol Biol Phys. 2008 Aug 1; 71(5):1591-9

Lin SH, Sugar E, Teslow T, McNutt T, Saleh H, Song DY, “Comparison of daily couch shifts using MVCT (TomoTherapy) and B-mode ultrasound (BAT System) during prostate radiotherapy.”  Technol Cancer Res Treat. 2008 Aug; 7(4):279-85.

Ford E, Purger D, Tryggestad E, McNutt T, Christodouleas J, Rigamonti D, Shokek O, Won S, Zhou J, Lim M, Wong J, Kleinberg L, “A virtual frame system for stereotactic radiosurgery planning”. Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1244-9.

Robert Jacques, Russell Taylor, John Wong, Todd McNutt ,” Towards Real-Time Radiation Therapy: GPU Accelerated Superposition/Convolution,”  MICCAI Sept. 2008 – Buffalo NY

Jacques,R.; Taylor,R.; Wong,J.; McNutt,T., “Towards real-time radiation therapy: GPU accelerated superposition/convolution”  Comput.Methods Programs Biomed., 2009

David Purger, Todd McNutt, Pragathi Achanta, Alfredo Quiñones-Hinojosa, John Wong and Eric Ford,” A histology-based atlas of the C57BL/6J mouse brain deformably registered to in vivo MRI for localized radiation and surgical targeting”, Phys. Med. Biol. 54 (2009) 7315–7327

Michael Kazhdan, Patricio Simari, Todd McNutt, Binbin Wu, Robert Jacques, Ming Chuang, and Russell Taylor, “A Shape Relationship Descriptor for RadiationTherapy Planning” Medical Image

Computing and Computer-Assisted Intervention 5762/2009(12), 100–108 (2009)

Binbin Wu, Francesco Ricchetti, Giuseppe Sanguineti, Misha Kazhdan, Patricio Simari, Ming Chuang, Russell Taylor, Robert Jacques, Todd McNutt, ”Patient Geometry-Driven Information Retrieval for IMRT Treatment Plan Quality Control”, Medical Physics, 2009 Dec; 36(12):5497-505

Susil RC, McNutt TR, Deweese TL, Song D , “Effects of Prostate-Rectum Separation on Rectal Dose From External Beam Radiotherapy “, Int J Radiat Oncol Biol Phys. 2010 Mar. 15; 76(4):1251-8

Seth D. Goldstein, Eric C. Ford, Mario Duhon, Todd McNutt, John Wong, Joseph M. Herman, “Use of Respiratory-Correlated Four-Dimensional Computed Tomography to Determine Acceptable Treatment Margins for Locally Advanced Pancreatic Adenocarcinoma”,  Int J Radiat Oncol Biol Phys. 2010 Feb 1; 76(2):597-602. Epub 2009 Oct 14

Horská A, Laclair A, Mohamed M, Wells CT, McNutt T, Cohen KJ, Wharam M, Mahone EM, Kates W. “Low cerebellar vermis volumes and impaired neuropsychologic performance in children treated for brain tumors and leukemia.” AJNR Am J Neuroradiol. 2010 Sep; 31(8):1430-7. Epub 2010 May 6.

Wu, B., Ricchetti, F., Sanguineti, G., Kazhdan, M., Simari, P., Jacques, R., Taylor, R., McNutt, T.: “Data-driven approach to generating achievable dose-volume histogram objectives in intensity modulated radiotherapy planning”. International Journal of Radiation Oncology, Biology, Physics 2011 Mar 15; 79(4):1241-7. Epub 2010 Aug

Patricio Simari, Binbin Wu, Robert Jacques, Alex King, Todd McNutt, Russell Taylor, and Michael Kazhdan,” A Statistical Approach for Achievable Dose Querying in IMRT Planning” Medical Image Computing and Computer-Assisted Intervention 5762/2009(12), 100–108 (2009)

Simari P, Wu B, Jacques R, King A, McNutt T, Taylor R, Kazhdan M. “A statistical approach for achievable dose querying in IMRT planning.” Med Image Comput Comput Assist Interv. 2010; 13(Pt 3):521-8.

Kang, J. Ford, E. Smith, K. Wong, J., McNutt, T. “A method for optimizing linac treatment geometry for volumetric modulated arc therapy of multiple brain metastases”, Med. Phys. 2010 Aug; 37(8):4146-54

B. Wu, M. Kazhdan,P. Simari, r. Taylor, T. McNutt, “ A Geometry-Driven Approach for Predicating DVHs of Organs at Risk in IMRT Planning,” Proceedings of the XVIth Int’l Conf on Computers in Radiotherapy June 1, 2010

J. Wong, P. Kazanzides, I. Iordachita,M. Matinfar, M. Armour, R. Jacques, E. Ford, E. Tryggestad, T. McNutt, J.-J. Sonke, “A Second Generation Small Animal Radiation Research Platform (SARRP)”, XVIth Int’l Conf on Computers in Radiotherapy June 1, 2010

R. Jacques, D. Smith, E. Tryggestad, J. Wong, R. Taylor, T. McNutt, “GPU Accelerated Real Time KV/MV Dose Computation, “ Proceedings of the XVIth Int’l Conf on Computers in Radiotherapy June 1, 2010

T. McNutt, J. Wong, J. Purdy, R. Valicenti, T. DeWeese, “OncoSpace: A New Paradigm for Clinical Research and Decision Support in Radiation Oncology”  Proceedings of the XVIth Int’l Conf on Computers in Radiotherapy June 1, 2010

Clemente S, Wu B, Sanguineti G, Fusco V, Ricchetti F, Wong J, McNutt T,, “SmartArc-Based Volumetric Modulated Arc Therapy for Oropharyngeal Cancer: A Dosimetric Comparison with Both Intensity-Modulated Radiation Therapy and Helical Tomotherapy”. Int J Radiat Oncol Biol Phys. 2010 Oct 13.

Hobbs RF,  McNutt T, Baechler S, He B, Esaias CE, Frey EC, Loeb DM, Wahl RL, Shokek O, Sgouros G, “A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy.” .Int J Radiat Oncol Biol Phys. 2010 Oct 13.

Jacques, R. Wong, J. Taylor, R. McNutt, T.” Real-Time Dose Computation: GPU Accelerated Source Modeling and Superposition/Convolution”, Med Phys. 2011 Jan; 38(1):294-305.

Ricchetti F, Wu B, McNutt T, Wong J, Forastiere A, Marur S, Starmer H, Sanguineti G., “Volumetric change of selected organs at risk during IMRT for oropharyngeal cancer.”, Int J Radiat Oncol Biol Phys. 2011 May 1; 80(1):161-8. Epub 2010 Nov 19

 

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