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John W. Wong, PhD

Phone number: (410) 502-1458

E-mail: jwong35@jhmi.edu

Interests: Advanced treatment technologies; Informatics for data sharing and decision support; Image guided pre-clinical radiation research

Titles: Professor; Director of Medical Physics

Schools\degrees: University of Toronto\PhD, Medical biophysics

Clinical interests: Adaptive radiation therapy; Methods of motion management in radiation therapy; Image and information guided radiation therapy

Research summary: My clinical research interests focus on the development advanced radiation treatment techniques to improve tumor eradication while minimizing radiation-induced toxicity.  I am on the invention team of the Active Breathing Control device to manage breathing motion during treatment, as well as Cone-beam CT (CBCT) with a flat panel imager on board a medical accelerator to facilitate CT guided radiation treatment.  More recently, I am exploring the use of on-board 3D ultrasound and CBCT as the surrogate imaging methods to bring multi-modality imaging information, such as MRI, to guide radiation treatment. 

In the informatics area, I am a co-principal investigator with Drs. McNutt and DeWeese in developing the multidisciplinary and multi-institutional “OncoSpace” informatics infra-structure to support data reuse and promote distributed data sharing for clinical research and decision making. 

In the laboratory, I have developed a unique small animal radiation research platform with CT imaging capability to support the translation of pre-clinical radiation research for human treatment.  The system is being enhanced to incorporate molecular-optical tomography to guide radiation and assess response.

Journal citations (selected from 120)

Martinez A, Yan D, Lockman D, Brabbins D, Kota K, Sharpe M, Jaffray D, Vicini F, Wong J: Improvement in dose escalation using the process of adaptive radiation therapy combined with 3D conformal or intensity modulated beams for prostate cancer, Int J Radiat Oncol Biol Phys 50, 1226-1234, 2001.

Jaffray DA, Siewerden JH, Wong JW, Martinez AA: “Flat-panel cone-beam computed tomography for image guided radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 53: 1337-1349, 2002.

Letourneau D, Martinez AA, Lockman D, Yan D, Vargas C, Ivaldi G, Wong J. Assessment of residual error for online cone-beam CT-guided treatment of prostate cancer patients. Int J Radiat Oncol Biol Phys. 62: 1239–1246, 2005

Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jinag SB, Kapatoes JM, Low DA, Murphy MJ, Murray BR, Ramsey CR, Van Herk MB, Vedam SS, Wong JW, Yorke E. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med. Phys 33: 3874-3900, 2006.

Wong J, Armour E, Kazanzides P, Iordachita I, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu Z, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese T. A high resolution small animal radiation research platform (SARRP) with x-ray tomographic guidance capabilities.  Int J Radiat Oncol Biol Phys. 2008; 71(5):1591-1599. PMID: 18640502

Jacques R, Taylor R, Wong J, McNutt T.  Towards Real-Time Radiation Therapy: GPU Accelerated Superposition/Convolution. High-Performance Medical Image Computing and Computer Aided  Intervention (HP-MICCAI), New York, 2008, In electronic proceedings at http://www.cse.buffalo.edu/hpmiccai/

M. Matinfar, E. Ford, I. Iordachita, J. Wong and P. Kazanzides, Image Guided Small Animal Radiation Research Platform: Calibration of Treatment Beam Alignment, Journal of Physics in Medicine and Biology, 54 (2009) 1–15 PMID: 19141881

Tryggestad E, Armour M, Iordachita I, Verhaegen F, Wong JW. A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Phys Med Biol. 2009 Sep 7;54(17):5341-57. PMID: 19687532.

Purger D, McNutt T, Achanta P, Quinones-Hinojosa A, Wong J, Ford E. A histology-based atlas of the C57BL/6J mouse brain deformably registered to in vivo MRI for localized radiation and surgical targeting. Phys Med Biol. 2009; 54(24):7315-27. PMID: 19926915

Ford EC, Gaudette R, Myers L, Vanderver B, Engineer L, Zellars R, Song DY, Wong J, Deweese TL. Evaluation of safety in a radiation oncology setting using failure mode and effects analysis. Int J Radiat Oncol Biol Phys. 74(3): 852-8, 2009.

McNutt T, Wong J, Purdy J, Valicenti R, DeWeese T. OncoSpace: A New Paradigm for Clinical Research and Decision Support in Radiation Oncology Proceedings of the XVIth International Conference on the Use of Computers in Radiation Therapy, Amsterdam, 2010, Editor Jan-Jakob Sonke, Published by Het Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis ISBN: 978-90-75575-29-3

Yin F, Wong J, Balter J, Benedict S, Bissonnette JP, Craig T, Dong L, Jaffray D, Kim S, Ma C, Munro P, Solberg T, Wu QJ, The role of in-room kV x-ray imaging for patient setup and target localization.  AAPM Report 104, Task Group 104 of the Therapy Imaging Committee, AAPM, 2010.

Vicini F, Winter K, Wong J, Pass H, Rabinovitch R, Chafe S, Arthur D, Petersen I, White J, McCormick. Initial Efficacy Results of RTOG 0319: Three-Dimensional Conformal Radiation Therapy (3D-CRT) Confined to the Region of the Lumpectomy Cavity for Stage I/ II Breast Carcinoma. Int J Radiat Oncol Biol Phys.15;77(4):1120-1127, 2010.

Kang J, Smith K, McNutt T, Wong J, Ford E.  A method for optimizing LINAC treatment geometry for volumetric modulated arc therapy of multiple brain metastases’ Med. Phys. 37, 4146- 4155, 2010.

Armour M, Ford E, Iordachita I, Wong J. CT guidance is needed to achieve reproducible positioning of the mouse head for repeat precision cranial irradiation. Radiat Res. 2010 Jan;173(1):119-23. PMID: 20041766

Cao X, Wu X, Frassica D, Yu B, Pang L, Xian L, Wan M, Lei W, Armour M, Tryggestad E, Wong J, Wen CY, Lu WW, Frassica FJ. Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proc Natl Acad Sci USA. 2011, 108(4):1609-14. PMID:21220327

 

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