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This project is funded by a NHLBI R24 grant for Investigator-Initiated Resource-Related Research Projects. This project aims to assist researchers studying acute respiratory distress syndrome (ARDS)/acute respiratory failure (ARF) patients in designing trials that appropriately evaluate long-term patient outcomes, in order to facilitate research aimed at reducing the public health burden of health impairments after these critical illnesses. This project includes: 1)creation and dissemination of a national Web-based database of validated and recommended survey instruments and clinical testing methods for evaluating ARDS/ARF survivors’ long-term physical, cognitive, and mental health outcomes; 2) development and dissemination of practical resources for maximizing retention of ARDS/ARF survivors in long-term, longitudinal research studies; and 3) evaluation, implementation and dissemination of statistical methods and programs for evaluating longitudinal functional outcomes in the presence of high patient mortality (“censoring due to death”).
This study examines the long-term patient outcomes, at 6 and 12 months after enrollment into four NIH-funded ARDS Network clinical trials for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients. Long-term outcomes of interest include measures of physical, cognitive and mental health. Participant evaluations are done via a battery of validated surveys by phone (estimated sample size = 900 from 41 hospitals at 11 study sites across United States) and for a sub-set of participants, in-person evaluation is conducted (estimated sample size = 300 from 11 hospitals at 4 study sites).
This study evaluates the effects of lower tidal volume ventilation and other aspects of critical illness and ICU care on the long-term physical and mental health outcomes of participants with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Follow-up evaluations are done at 3, 6, 12, 24, 36, 48 and 60 months after the diagnosis of ALI/ARDS.
This study investigates changes and recovery in muscle electrophysiology and function during critical illness in order to understand mechanisms through which critical illness and ICU therapies contribute to long-term impairments in muscle strength, physical function and quality of life. Participants are drawn from the ongoing NIH-funded ARDS Network randomized controlled trials and have long-term follow-up conducted as part of the ARDS Network Long-term Outcomes Study (ALTOS – see details above).
The purpose of this study is to understand patients’ neurocognitive performance at discharge from the Medical Intensive Care Unit (MICU) and the potential effect of perceived sleep quality in the MICU on neurocognitive outcomes.
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness. The study is a randomized clinical trial to evaluate the efficacy of twice-daily NMES versus sham therapy, applied to the bilateral lower extremities, to reduce ICU-associated weakness in patients with acute respiratory failure.
This multi-centered randomized controlled trial investigates whether Functional Electrical Stimulation-Assisted Cycle Ergometry (FES-Cycling) delivered early during critical illness in mechanically ventilated patients decreases intensive care unit-acquired weakness (ICU-AW). This trial’s main outcome measures include muscle strength, muscle mass and physical functioning. In a sub-group of patients, biochemical and histological changes in muscles will be evaluated via muscle biopsy. Participants also will receive 6-month follow-up to evaluate their physical, cognitive and mental health outcomes.