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Selected Research Publications

Silvio O. Conte Center for Schizophrenia Research at Johns Hopkins

2009

Jaaro-Peled, H., Hayashi-Takagi, A., Seshadri, S., Kamiya, A., Brandon, N.J., and Sawa, A. (2009). Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci 32, 485-495 [Abstract]

Khanna, H., Davis, E.E., Murga-Zamalloa, C.A., Estrada-Cuzcano, A., Lopez, I., den Hollander, A.I., Zonneveld, M.N., Othman, M.I., Waseem, N., Chakarova, C.F., Maubaret, C., Diaz-Font, A., MacDonald, I., Muzny, D.M., Wheeler, D.A., Morgan, M., Lewis, L.R., Logan, C.V., Tan, P.L., Beer, M.A., Inglehearn, C.F., Lewis, R.A., Jacobson, S.G., Bergmann, C., Beales, P.L., Attié-Bitach, T., Johnson, C.A., Otto, E.A., Bhattacharya, S.S., Hildebrandt, F., Gibbs, R.A., Koenekoop, R.K., Swaroop, A., and Katsanis, N. (2009). A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. Nat Genet 41, 739-745 [Abstract]

Kim, J.Y., Duan, X., Liu, C.Y., Jang, M.H., Guo, J.U., Pow-anpongkul, N., Kang, E., Song, H., and Ming, G.L. (2009). DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63, 761-773 [Abstract]

McGrath, J.A., Avramopoulos, D., Lasseter, V.K., Wolyniec, P.S., Fallin, M.D., Liang, K.Y., Nestadt, G., Thornquist, M.H., Luke, J.R., Chen, P.L., Valle, D., and Pulver, A.E. (2009). Familiality of novel factorial dimensions of schizophrenia. Arch Gen Psychiatry 66, 591-600 [Abstract]

Johnson, A.W., Gallagher, M., and Holland, P.C. (2009). The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects. J Neurosci 29, 696-704 [Abstract]

2010

Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A.J., Makino, Y., Seshadri, A.J., Ishizuka, K., Srivastava, D.P., Xie, Z., Baraban, J.M., Houslay, M.D., Tomoda, T., Brandon, N.J., Kamiya, A., Yan, Z., Penzes, P., and Sawa, A. (2010). Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci 13, 327-332 [Abstract]

Niwa, M., Kamiya, A., Murai, R., Kubo, K., Gruber, A.J., Tomita, K., Lu, L., Tomisato, S., Jaaro-Peled, H., Seshadri, S., Hiyama, H., Huang, B., Kohda, K., Noda, Y., O'Donnell, P., Nakajima, K., Sawa, A., and Nabeshima, T. (2010). Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 65, 480-489 [Abstract]

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K.L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I.N., Cadet, J.L., Pardo, C., Mori, S., Kamiya, A., Vogel, M.W., Sawa, A., Ross, C.A., and Pletnikov, M.V. (2010). Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry 68, 1172-1181 [Abstract]

Zaghloul, N.A., Liu, Y., Gerdes, J.M., Gascue, C., Oh, E.C., Leitch, C.C., Bromberg, Y., Binkley, J., Leibel, R.L., Sidow, A., Badano, J.L., and Katsanis, N. (2010). Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 107, 10602-10607 [Abstract]

Koh, M.T., Haberman, R.P., Foti, S., McCown, T.J., and Gallagher, M. (2010). Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 35, 1016-1025 [Abstract]

2011

Ishizuka, K., Kamiya, A., Oh, E.C., Kanki, H., Seshadri, S., Robinson, J.F., Murdoch, H., Dunlop, A.J., Kubo, K., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M.D., Katsanis, N., and Sawa, A. (2011). DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 473, 92-96 [Abstract]

Brandon, N.J., and Sawa, A. (2011). Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 12, 707-722 [Abstract]

Kang, E., Burdick, K.E., Kim, J.Y., Duan, X., Guo, J.U., Sailor, K.A., Jung, D.E., Ganesan, S., Choi, S., Pradhan, D., Lu, B., Avramopoulos, D., Christian, K., Malhotra, A.K., Song, H., and Ming, G.L. (2011). Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron 72, 559-571 [Abstract]

Fallin, M.D., Lasseter, V.K., Liu, Y., Avramopoulos, D., McGrath, J., Wolyniec, P.S., Nestadt, G., Liang, K.Y., Chen, P.L., Valle, D., and Pulver, A.E. (2011). Linkage and association on 8p21.2-p21.1 in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 156, 188-197 [Abstract]

Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I.N., Sawa, A., Margolis, R.L., Cadet, J.L., Mori, S., Vogel, M.W., Ross, C.A., and Pletnikov, M.V. (2011). Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry 16, 293-306 [Abstract]

Stranahan, A.M., Haberman, R.P., and Gallagher, M. (2011). Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats. Cereb Cortex 21, 392-400 [Abstract]

2012

Golzio, C., Willer, J., Talkowski, M.E., Oh, E.C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J.F., Kamiya, A., Beckmann, J.S., and Katsanis, N. (2012). KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature 485, 363-367 [Abstract]

Kano, S., Colantuoni, C., Han, F., Zhou, Z., Yuan, Q., Wilson, A., Takayanagi, Y., Lee, Y., Rapoport, J., Eaton, W., Cascella, N., Ji, H., Goldman, D., and Sawa, A. (2012). Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry AOP [Abstract]

Taniguchi, Y., Young-Pearse, T., Sawa, A., and Kamiya, A. (2012). In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist 18, 169-179 [Abstract]

Ma, T.M., Abazyan, S., Abazyan, B., Nomura, J., Yang, C., Seshadri, S., Sawa, A., Snyder, S.H., and Pletnikov, M.V. (2012). Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol Psychiatry [Abstract]

Severance, E.G., Alaedini, A., Yang, S., Halling, M., Gressitt, K.L., Stallings, C.R., Origoni, A.E., Vaughan, C., Khushalani, S., Leweke, F.M., Dickerson, F.B., Yolken, R.H. (2012) Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res 138:48-53 [Abstract]

Severance, E.G., Kannan, G., Gressitt, K.L., Xiao, J., Alaedini, A., Pletnikov, M.V., and Yolken, R.H. (2012). Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice. PLoS One 7, e50991 [Abstract]

2013

Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N., Kano, S., Ozaki, N., Nabeshima, T., Sawa, A. (2013). Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science, 339, 335-339 [Abstract]

Coughlin, J.M., Ishizuka, K., Kano, S.I., Edwards, J.A., Seifuddin, F.T., Shimano, M.A., Daley, E.L., Zandi, P.P., Leweke, F.M., Cascella, N.G., Pomper, M.G., Yolken, R.H., and Sawa, A. (2013). Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry 18, 10-11 [Abstract]

 
 
 
 
 
 

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