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Research Publications

Obsessive-Compulsive Disorder Program

Research Articles | Review Articles | Book Chapters

RESEARCH ARTICLES

1.  Nestadt G, Samuels JF, Romanoski AJ, Folstein MF, McHugh PR. Obsessions and compulsions in the community.  Acta Psychiatrica Scandinavica 1994;  89:219-224.

2. Nestadt G, Bienvenu OJ, Cai G, Samuels J, Eaton WW.  Incidence of obsessive-compulsive disorder in adults.  Journal of Nervous and Mental Disease 1998; 186:401-406.

3. Nestadt G, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R: A family study of obsessivecompulsive disorder.  Archives of General Psychiatry 2000; 57:358-363.

4. Bienvenu OJ, Samuels J, Riddle MA, Hoehn-Saric R, Liang KY, Cullen BA, Grados MA, Nestadt G: The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study.  Biological Psychiatry 2000; 48:287-293.

5. Samuels J, Nestadt G, Bienvenu OJ, Costa PT Jr, Riddle MA, Liang KY, Hoehn-Saric R, Grados MA, Cullen BA: Personality disorders and normal personality dimensions in obsessive-compulsive disorder: results from the Johns Hopkins OCD Family Study. British Journal of Psychiatry 2000; 177:457-462.

6. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, Hoehn-Saric  R, Cullen B, Grados M, Beaty TH, Shugart YY:  Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder (OCD) and heterogeneity by gender. American Journal of Human Genetics 2000; 67:1611-1616.

7. Nestadt G, Samuels J, Riddle MA, Liang KY, Bienvenu OJ, Hoehn-Saric R, Grados M, Cullen B: The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study.  Psychological Medicine 2001; 31:481-487.

8. Cullen BA, Samuels JF, Bienvenu OJ, Grados M, Hoehn-Saric R, Hahn J, Liang KY, Wellen D, Dees M, Riddle MA, Nestadt G: Pathological skin picking and obsessive-compulsive disorder. Journal of Nervous and Mental Disease 2001; 189: 193-195.

9. Grados MA, Riddle MA, Samuels J, Liang KY, Hoehn-Saric R, Bienvenu OJ, Walkup JT, Song D, Nestadt G: The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Johns Hopkins OCD Family Study. Biological Psychiatry  2001; 50:559-565.

10. Nestadt G, Samuels J, Riddle MA, Bienvenu OJ, Liang KY, Grados MA, Cullen B: Obsessive-compulsive disorder: defining the phenotype. Journal of Clinical  Psychiatry 2002; 63(suppl 6): 5-7.

11. Samuels J, Bienvenu OJ, Riddle MA, Cullen BA, Grados MA, Liang KY, Hoehn-Saric R, Nestadt G: Hoarding in obsessive-compulsive disorder: results from a case-control study. Behavior Research and Therapy 2002; 40:517-528.

12. Nestadt G, Addington A, Samuels J, Liang KY, Bienvenu OJ, Riddle M, Grados M, Hoehn-Saric R, Cullen B: Identification of OCD-related subgroups based on comorbidity.  Biological Psychiatry 2003; 53:914-920.

13. Willour VL, Shugart YY, Samuels J, Grados M, Cullen B, Bienvenu OJ 3rd, Wang Y, Liang KY, Valle D, Hoehn-Saric R, Riddle M, Nestadt G: Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder.  American Journal of Human Genetics 2004; 75:508-513.

14. Hong JP, Samuels J, Bienvenu OJ 3rd, Cannistraro P, Grados M, Riddle MA, Liang KY, Cullen B, Hoehn-Saric R, Nestadt G:  Clinical correlates of  recurrent  major depression in obsessive-compulsive disorder.  Depression and Anxiety 2004; 20:92-97.

15. Shugart YY, Samuels J, Willour L, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J,  Pauls DL, Cullen B, Page J, Rasmussen SA, Bienvenu OJ, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G: Genome-wide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 15q, 6q, and 1q.  Molecular Psychiatry 2006; 11:763-770.

16. Samuels JF, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy  DL, Grados MA, Pinto A, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Bienvenu OJ 3rd, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G: The OCD Collaborative Genetics Study: methods and sample description. American Journal of Medical Genetics Part B  (Neuropsychiatric Genetics) 2006; 141B(3):201-207

17. Wellen D, Samuels J, Bienvenu OJ, Grados M, Cullen B, Riddle M, Liang KY, Nestadt G: The utility of the Leyton Obsessional Inventory in distinguishing OCD and OCPD. Depression and Anxiety 2006; 24:301-306.

18. Samuels JF, Bienvenu OJ, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Greenberg BD, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G: Hoarding in obsessive- compulsive disorder: results from the OCD Collaborative Genetics Study. Behavior Research and Therapy 2007; 43:673-686.

19. Cullen B, Brown CH, Riddle MA, Grados M, Bienvenu OJ, Willour VL, Hoehn-Saric R, Shugart YY, Liang K-Y, Samuels J, Nestadt G: Factor analysis of  the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive compulsive disorder. Depression and Anxiety 2007; 24:130-138.

20. Hasler G, Pinto A, Greenberg BD, Samuels J, Fyer AJ, Pauls D, Knowles JA, McCracken JT, Piacentini J, Riddle MA, Rauch SL, Rasmussen SA, Willour VL, Grados MA, Cullen B, Bienvenu OJ, Shugart YY, Liang KY, Hoehn-Saric R, Wang Y, Ronquillo J, Nestadt G, Murphy DL: Familiality of  factor analysis-derived YBOCS dimensions in OCD affected sibling pairs from the OCD Collaborative Genetics Study.  Biological Psychiatry 2007; 
      61:617-625.

21. Samuels J, Shugart YY, Grados MA, Willour VL, Bienvenu OJ, Greenberg BD, Knowles, JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Rasmussen SA, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G: Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive compulsive disorder. American Journal of Psychiatry 2007; 164:493-499.

22. Messias E, Eaton W, Bienvenu OJ, Nestadt G, Samuels J: Psychiatrist- ascertained treatment needs for mental disorders in a population-based sample.  Psychiatric Services 2007; 58:373-7.

23. Grados J, Samuels J, Shugart YY, Willour VL, Wang Y, Cullen B, Bienvenu OJ, Hoehn-Saric R, Valle D, Liang K-Y, Riddle MA, Wendland JR, Murphy DL, Nestadt G, Detera-Wadleigh S. Rare plus common SERT variants in obsessive-compulsive disorder. Molecular Psychiatry 2007;12:422-423.

24. Cullen B, Samuels JF, Pinto A, Fyer AJ, McCracken JT, Rauch SL,  Murphy DL, Greenberg BD, Knowles JA, Piacentini J, Bienvenu OJ 3rd, Grados MA, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G:  Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder. Depression and Anxiety 2008; 25:218-224.

25.  Cullen B, Samuels J, Grados M, Landa R, Bienvenu OJ, Liang K-Y, Riddle M, Hoehn-Saric R, Nestadt G: Social and communication difficulties and obsessive-compulsive disorder. Psychopathology 2008; 41:194-200.

26.  Samuels JF, Bienvenu OJ, Grados MA, Cullen B, Riddle MA, Liang KY, Eaton WW, Nestadt G: Prevalence and correlates of hoarding behavior in a  community-based sample. behavior Research and Therapy 2008; 46:836-844.

27.  Pinto A, Greenberg BD, Grados MA, Bienvenu OJ, Samuels JF, Murphy DL, Hasler G, Stout RL, Rauch SL, Shugart YY, Pauls DL, Knowles JA, Fyer AJ, McCracken JT, Piacentini J, Wang Y, Willour VL, Cullen B, Liang K-Y, Hoehn-Saric R, Riddle MA, Rasmussen SA, Nestadt G:  Further  development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs categories.  Psychiatry Research 2008; 160:83-93.

28.  Samuels JF, Bienvenu OJ, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Greenberg BD, Knowles JA, Piacentini J, Cullen B,Riddle MA, Rasmussen SA, Pauls DL, Liang K-Y, Hoehn-Saric R, Pulver AE, Nestadt G:  Sex-specific clinical correlates of hoarding in obsessive- compulsive disorder. behavior Research and Therapy 2008; 46:1040-1046.

29.  Liang K-Y, Wang Y, Shugart YY, Grados MA, Fyer AJ, Rauch SL, Murphy DL, McCracken JT, Rasmussen SA, Cullen B, Hoehn-Saric R, Greenberg BD, Pinto A, Knowles JA, Piacentini J, Pauls DL, Bienvenu OJ, Riddle M, Samuels JF, Nestadt G: Evidence for potential relationship between EAAC1 (SLC1A1) and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding. American Journal of Medical Genetics Part B  (Neuropsychiatric Genetics)  2008; 147B:1000-1002.

30.  Wilcox HC, Grados M, Samuels J, Riddle MA, Bienvenu OJ III, Pinto A, Cullen B, Wang Y, Shugart YY, Liang KY, Nestadt G: Association of parental bonding with obsessive compulsive disorder in offspring at high familial risk. Journal of Affective Disorders 2008; 111:31-39.

31.  Wang Y, Samuels JF, Chang YC, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Rasmussen SA, Cullen B, Hoehn- Saric R, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Bienvenu OJ, Riddle MA, Shugart YY, Liang KY, Nestadt G: Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 2009; 150B:33-40.

32.  Bienvenu OJ, Wang Y, Shugart YY, Welch JW, Grados MA, Fyer AJ, Rauch SL, McCracken JT, Rasmussen SA, Murphy DL, Cullen B, Valle D, Hoehn- Saric R, Greenberg BD, Pinto A, Knowles JA, Piacentini J, Pauls DL, Liang KY, Riddle MA, Samuels JF, Feng G, Nestadt G. Sapap3 gene appears associated with pathological grooming in humans. American Journal of  Medical  Genetics Part B  (Neuropsychiatric Genetics) (in press).

33.  Shugart YY, Wang Y, Samuels JF, Chang YC, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Rasmussen SA, Cullen B, Hoehn- Saric R, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Bienvenu OJ, Riddle MA, Liang KY, Nestadt G: A family based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. American Journal of Medical Genetics Part B  (Neuropsychiatric Genetics) (in press).

34.  Nestadt G, Di CZ , Riddle MA, Grados MA, Greenberg BD, Fyer AJ,  McCracken JT, Rauch SL, Murphy DL, Rasmussen SA, Cullen B, Hoehn-Saric R,  Pinto A, Knowles JA, Piacentini J, Pauls DL, Bienvenu OJ, Wang Y, KY Liang KY, Samuels JF, Bandeen Roche K: Obsessive-compulsive disorder: sub-classification based on comorbidity. Psychological Medicine (in press).

35.  Wang Y, Admaczyk A, Shugart YY, Samuels JF, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Rasmussen SA, Cullen B, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Bienvenu OJ, Riddle M, Liang KY, Valle D, Wang T, Nestadt G: A screen of SLC1A1 for OCD-related alleles. American Journal of Medical Genetics Part B  (Neuropsychiatric Genetics) (in press).

REVIEW ARTICLES

1.  Samuels J, Nestadt G. Epidemiology and genetics of obsessive compulsivedisorder. International Review of Psychiatry 1997; 9:61-71.

2.  Samuels J. Recent advances in the genetics of obsessive-compulsivedisorder. Current Psychiatry Reports (in press).

BOOK CHAPTERS

1.  Costa PT Jr, Samuels J, Bagby M, Daffin L, Norton H. Obsessive-Compulsive Personality Disorder (OCPD): a Review. In: Maj M, Akiskal H, Mezzich J, Okasha A (Eds.), Personality Disorders  (WPA Series, Evidence and Experience in Psychiatry, Vol. 8). West Sussex, UK, Wiley & Sons, 2005, pp. 405-439.

2.  Samuels JF, Grados MA, Planalp E, Bienvenu OJ. Genetic Understanding of OCD and Spectrum Disorders.  In: Steketee G (Editor), Oxford Handbook of  Obsessive Compulsive and Spectrum Disorders (Oxford Library of  Psychology Series). New York, Oxford University Press (in press).

 
 
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