Skip Navigation
 
 
 
 
 
Print This Page
Share this page: More
 

Obsessive-Compulsive Disorders Research

Obsessive-Compulsive Disorder Program

Family and Genetic Studies of OCD

Principal Investigator: Gerald Nestadt, M.D., M.P.H.

The goal of this research program is to elucidate the causes and pathophysiology of obsessive-compulsive disorder (OCD).  The program was initiated in the 1990’s to investigate the genetic etiology of OCD. 

In the OCD Family Study (1996-2001), we evaluated over 800 individuals in 153 families. We found the occurrence of OCD to be six times greater in relatives of OCD cases than in relatives of the control group. Other anxiety disorders, especially agoraphobia and generalized anxiety disorder, also were more prevalent in case families. Segregation analysis provided evidence that genes of major effect are involved in OCD. 

In the OCD Collaborative Genetics Study (2001-2007), we directed a genetics study of OCD in collaboration with five other academic centers in the United States. The collaboration diagnostically evaluated and collected DNA samples from over 200 affected sibling pairs, and completed the first large genome-wide genetic linkage scan of OCD. We found evidence of genetic linkage of OCD to regions on chromosomes 1, 3, 6, 7, and 15. We also found intrafamilial correlation of factor dimensions, especially hoarding behavior, in OCD families.  In addition, we found significant linkage of compulsive hoarding behavior to a region on chromosome 14. We have been following up these findings with fine mapping of these regions and family-based association studies of functional candidate genes.  This research has been funded by grants from the National Institutes of Health, the OCD Foundation, and the James E. Marshall OCD Foundation.

In the current OCD Collaborative Genetics Association Study (2007 - ), we and our collaborators at five other academic centers are interviewing and collecting DNA samples from 2000 individuals with OCD and their parents.  We will conduct a genome-wide association study to identify even smaller chromosomal regions associated with OCD.

Our research continues to be funded by the National Institute of Mental Health (NIMH), the James E. Marshall OCD Foundation, and the OC Foundation.

Interested in participating? Click here

 
 
YOU ARE INVITED
to Participate in Research

We are now investigating genetic factors which may increase the susceptibility to OCD (Obsessive Compulsive Disorder). We are seeking help from families with OCD to help to conduct these studies. Participants do not need to travel. Confidentiality of all information is assured. Participants will be compensated.

Individuals with OCD are invited to participate in our study.  
>More

Research Hope graphic

READ OCDigest

The Newsletter of the OCD
Family Study
> More

 

     

Research Volunteers Needed

Psychiatry E-News Update

For Faculty & Staff

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer