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Neuroimaging Studies

Baltimore Huntington's Disease Center

We have conducted a series of clinical studies to define the course and progression of Huntington’s disease in patients. We have used volumetric structural MRI imaging to show the steady atrophy of the caudate and putamen of the striatum in the basal ganglia, the main area affected in HD, and have proposed that this measure may be a useful biomarker for clinical trials. More recently we have shown structural change begins well before the onset of HD in gene positive presymptomatic individuals. Our data have helped to provide the background for the multi-center PREDICT HD study (see Clinical Trials). We are currently using functional MRI and diffusion tensor imaging (DTI) measures to demonstrate functional changes and changes in white matter connectivity very early in the presymptomatic gene positive population.

Click here for the Psychiatric Neuroimaging Division.

For research information, please contact:

Gregory Churchill
Research Program Coordinator
Johns Hopkins University
600 N. Wolfe Street, Meyer 2-181
Baltimore, MD 21287

(410) 955-1349 desk
(410) 955-8233 fax


For information about viewing the HDSA Webinars at a different time, call or email the social worker, Kit McFarlane at 410-955-2497 or

Johns Hopkins / HDSA

For those concerned about all aspects of Huntington’s Disease: individuals, family, friends

Meets at 7PM
2nd Tuesday of the month at
Presbyterian Home of Maryland
400 Georgia Court
Towson, MD 21204

Park on the circular drive in front.
Enter up the ramp to the right of the main entrance. Call Kit McFarlane, facilitator, for directions and questions:

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The Hunt for Huntington's



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