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Obsessive-Compulsive Disorder (OCD)

Research in the Division of Child and Adolescent Psychiatry

Cytokine in Childhood Obsessive-Compulsive Disorder

Principal Investigator: Marco Grados, M.D., M.P.H.

This study aims to understand pattern of cytokine expression in childhood Obsessive Compulsive Disorder (OCD). Monthly assessments over a 12-month period are conducted in order to measure the level of OCD symptoms, tic severity, and general psychiatric symptoms of children aged 5-17 years. Hospital visits at months 1, 4, 8 and 12 employ blood tests to determine the expression of cytokine networks, ASO titers and other immune-marker measures. In months 2, 3, 5, 6, 7, 9, 10 and 11 the same measures (blood tests and tests for OCD and tics) are administered in the home or by phone (alternate months). Additionally, if a dramatic worsening in symptoms occurs in intervening months additional blood samples are obtained. Thus this study aims to understand if OCD symptoms fluctuate in parallel with cytokine network changes or other immune measures using a longitudinal design.

VOLUNTEERS being recruited for this study - Click here if you are interested.

Study Coordinator and

Marco Grados, M.D., M.P.H.


Home visits
The Johns Hopkins Hospital 
Division of Child and Adolescent Psychiatry
CMSC 3                 

Psychosocial Study of Childhood Obsessive-Compulsive Disorder

Principal Investigator: Marco Grados, M.D., M.P.H.

This study aims to understand the influence of individual psychopathology in children (ages 5-17 years) and parents, parent-child relationships and family functioning in families with children with OCD. The study is completed by self-report (mail) and interviews (phone) with families across the country. The questionnaires aim to provide an overall understanding of the environment which exists in families that have a child with OCD to better target interventions and measure the environmental component that may influence symptom expression.   

Study Contact:

Marco Grados, M.D., M.P.H.
Dr. Marco Grados

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