Focus The research in our laboratory is directed towards understanding the pathogenesis of neuropsychiatric illnesses, especially schizophrenia and neurodenerative disorders, at the molecular level. We take a multi-faceted approach from molecular biology and animal models, to clinical studies using patient subjects: In a bottom-up approach, we focus on concrete molecular targets, such as disease risk gene products and/or key cellular mediators. We test how such molecular targets are functionally related with each other in cells and neuronal networks of animal models, and how they contribute to development of disease phenotypes during a time course. In a top-down approach, clinical information and patient tissues are analyzed towards identifying novel molecular targets, or new biomarkers of disease. Selected Projects Neurobiology of Schizophrenia and Mood Disorders |
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