Selected Publications

The Sawa Laboratory

1. Jaaro-Peled H., Hayashi-Takagi A., Seshadri S., Kamiya A., Brandon N.J., and Sawa A. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through Neuregulin-1 and DISC1. Trends Neurosci, in press (2009)
2. Sen N., Hara M.R., Ahmed A., Cascio M.B., Kamiya A., Ehmsen J.T., Aggrawal N., Hester L., Dore S., Snyder S.H., and Sawa A. GOSPEL: A novel neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron, in press (2009) [PMC Journal In Process]
3. Sawa, A., Cascella, N.G.: Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia. Am. J. Psychiatry, 166; 137-139 (2009)
4. Kamiya, A., Tan, P.L., Kubo, K., Engelhard, C., Ishizuka, K., Kubo, A., Tsukita, S., Pulver, A.E., Nakajima, K., Cascella, N.G., Katsanis, N., and Sawa, A.: PCM1 is recruited to the centrosome by the cooperative action of DISC1 and BBS4 and is a candidate risk factor for psychiatric illness.  Arch. Gen. Psychiatry 65; 996-1006 (2008) [NIHMSID: 118652]
5. Sen, N., Hara,^, M.R., Kornberg, M.D., Cascio, M.B., Bae, B.I., Shahani, N., Thomas, B., Dawson, T.M., Dawson, V.L. Snyder, S.H., and Sawa, A.: Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.  Nature Cell Biol. 10; 866-873 (2008)
6. Hikida, T.,^, Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S., Sawa, A.: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.  Proc. Natl. Acad. Sci. USA 104; 14501-14506 (2007) [PMCID: PMC1964873]
7. Huntingtin: Nuclear translocation and cytotoxicity modulated by GAPDH. Proc. Natl. Acad. Sci. USA. 103(9); 3405-09 (2006)
8. M.R. Hara, B. Thomas, M.B. Cascio, A.S. Huang, S.K. Tankou, B.I. Bae, M.D. Kornberg, L.D. Hester, V.L. Dawson, T.M. Dawson, A. Sawa, and S.H. Snyder Neuroprotection by pharmacologic blockade of the GAPDH death cascade Proc. Natl. Acad. Sci. USA 103(10); 3887-89 (2006)
9. K. Fujii, K. Maeda, T. Hikida, A.K. Mustafa, R. Balkissoon, J. Xia, T.Yamada, Y. Ozeki, R. Kawahara, M. Okawa, R.L. Huganir, H. Ujike, S. H. Snyder and A. Sawa Serine racemase binds PICK1: potential relevance to schizophrenia. Mol. Psychiatry. 11(2); 150-57 (2006)
10. A. Kamiya, K. Kubo, T. Tomoda, M. Takaki, R. Youn, Y. Ozeki, N. Sawamura, U. Park, C Kudo, M. Okawa, C.A. Ross, M.E. Hatten, K. Nakajima, A. Sawa A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biol., 7; 1167-78 (2005)
11. A. Sawa, S.H. Snyder Genetics. Two genes link two distinct psychoses. Science; 310; 1128-9 (2005)
12. B.I. Bae, S. Igarashi, M. Fujimuro, N. Agrawal, Y. Taya, S.D. Hayward, T. Moran, C.A. Ross, S.H. Snyder, A. Sawa p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s disease. Neuron 47; 29-41 (2005)
13. M.R. Hara, N. Agrawal, S.F. Kim, M.B. Cascio, M. Fujimuro, M. Takahashi, J.H. Cheah, S.K. Tankou, L.D. Hester, C.D. Ferris, S.D. Hayward, S.H. Snyder, A. Sawa S-Nitrosylated glyceraldehyde-3-phosphate dehydrogenase initiates cell death by nuclear translocation following Siah1 binding. Nature Cell Biol., 7; 665-674 (2005)
14. N. Sawamura, T. Sawamura-Yamamoto, Y. Ozeki, C.A. Ross, and A. Sawa A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc. Natl. Acad. Sci. USA, 102; 1187-1192 (2005)
15. A. Sawa, M.V. Pletnikov, A. Kamiya, Neuron-glial interactions clarify genetic-environmental links in mental illness. Trends In Neuroscience 27; 294-297 (2004)
16. Y. Ozeki, T. Tomoda, J. Kleiderlein, A. Kamiya, L. Bord, K. Fujii, M. Okawa, N. Yamada, M. E Hatten, S.H. Snyder, C. A. Ross, A. Sawa Disrupted-In-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NUDEL and inhibits neurite outgrowth. Proc. Natl. Acad. Sci. USA, 100; 289-294 (2003)
17. A. Sawa, S.H. Snyder Schizophrenia: diverse approaches to a complex disease. Science, 296; 692-695 (2002)
18. H.R. Luo, A. Saiardi, E. Nagata, K. Ye, T.S. Jung, X. Luo, S. Jain, A. Sawa, S.H. Snyder GRAB: a physiologic guanine nucleotide exchange factor for Rab3A which interacts with inositol hexakisphosphate kinase. Neuron, 31; 439-451 (2001)
19. M. Fang, S.R. Jaffrey, A. Sawa, K. Ye, X. Luo, S.H. Snyder Dexras1; A G-protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron, 28; 183-193 (2000)
20. C. D. Ferris, S.R. Jaffery, A. Sawa, M. Takahashi, S. Brady, R. K. Barrow, S. Tyosoe, H. Wolosker, S. Dore, S.H. Snyder Heme oxygenase-1 prevents cell death by regulating cellular iron levels. Nature Cell Biol., 1; 152-157 (1999)
21. A. Sawa, G.W. Wiegand, J.K. Cooper, R.L. Margolis, A.H. Sharp, J.E. Lawler, J.T. Greenamyre, S.H. Snyder, C.A. Ross Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nature Med., 5; 1194-1198 (1999)