Smith, Wanli W., M.D., Ph.D.

Assistant Professor
Director, Cellular Neurobiology Laboratory

Main Office Address

CMSC 9-108B
The Johns Hopkins Hospital
600 North Wolfe St.
Baltimore, MD 21287

Phone: 410-502-4226 

E-mail: wsmith60@jhmi.edu 

Administrative Assistant

Adriana Fonseca
Phone: 410-614-0014

Education

Professional Interests

Cellular and molecular pathogenesis of neurodegenerative diseases including Parkinson’s Disease (PD), Alzheimer’s disease (AD), and obesity; neuronal cell death and protein aggregation in neuropsychiatric conditions.

Selected Publications

Wanli W. Smith, Zhong Pei, Haibing Jiang,  Valina L. Dawson, Ted M. Dawson, Christopher A. Ross. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neuroscience, 2006, 9(10):1231-3

Wanli. W. Smith, R.L. Margolis, X. Li, J.C. Troncoso, M.K. Lee, V.L.Dawson, T.M. Dawson, T. Iwatsubo, and C.A. Ross. Aalpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in Sh-Sy5Y cells. J. Neurosci. 2005 8;25(23):5544-52

Wanli W. Smith, Darrell D. Norton, Myriam Gorospe, Haibing Jiang, Nikki J. Holbrook, Shino Nemoto, Toren Finkel, John W. Kusiak. Phosphorylation of p66Shc and forkhead proteins mediates Ab toxicity. J Cell Biol. 2005, 25;169(2):331-9.

Wanli W. Smith, Haibing Jiang, Zhong Pei, Yuji Tanaka, Hokuto Morita, Akira Sawa, Valina L. Dawson, Ted M. Dawson and Christopher A. Ross.  Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha synuclein-induced toxicity. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet. 2005, 14(24):3801-11.

Wanli W. Smith, Zhong Pei, Haibing Jiang, Darren J. Moore, Yideng Liang, Andrew B. West, Valina L. Dawson, Ted M. Dawson, and Christopher A. Ross. LRRK2: Interaction with parkin and mutation-induced neuronal degeneration. Proc Natl Acad Sci U S A. 2005, 102(51):18676-81.