Smith, Gwenn, Ph.D.

Professor Main Office Address Department of Psychiatry     Johns Hopkins Bayview Medical Center 5300 Alpha Commons Drive, Fourth Floor Baltimore, MD 21224 Phone: 410-550-8696 Fax: 410-614-8042                                                               E-mail: gsmith95@jhmi.edu E-mail: gsmith95@jhmi.edu

Education

Professional Interests

The application of neurochemical brain imaging to understand the regulation of monoamine systems in pathophysiology and treatment response associated with affective and cognitive disorders. Current, active projects include the application of these methods to psychotic depression, geriatric depression and Alzheimer’s disease. Studies also focus on using these and other molecular imaging methods to understand the role of monoamine degeneration relative to other neurodegenerative processes (e.g. beta-amyloid deposition).

Selected Publications

Smith, GS, Gunning-Dixon, F., Lotrich, F., Taylor, W., Evans, J. (2007) Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research. Neuropsychopharmacology, 32(9):1857-75

Smith, G., Ma, Y., Dhawan, V., Chaly, T., Belakhleff, A., Eidelberg, D. (2009) Selective Serotonin Reuptake Inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography (PET). Synapse, 63(1):1-6

Smith, G., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D. (2009) Cholinergic Modulation of Serotonin Function Measured with PET in Alzheimer’s disease Brain, 2009 Feb;132(Pt 2):392-401

Smith, G., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D (2009) Serotonin modulation of cerebral glucose metabolism in geriatric depression, Biological Psychiatry, 1;66(3):259-66

Smith, G., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D (2009) The functional neuroanatomy of geriatric depression. International Journal of Geriatric Psychiatry, 24(8):798-808