Sedlak, Thomas W., M.D., Ph.D.

Assistant Professor Director, Adult Schizophrenia Consult Clinic Schizophrenia Center Molecular Psychiatry Program Sedlak Lab Main Office Address Meyer 3-166B Department of Psychiatry and Behavioral Science Johns Hopkins School of Medicine 600 North Wolfe St. Baltimore, MD 21287-5371 Phone: 410-614-5995 Fax: 410-614-1792 E-mail: tsedlak@jhmi.edu

Education

Professional Interests

Our laboratory studies brain metabolic and antioxidant pathways relevant to normal brain biology and neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease.

Selected Publications

Koga M, Serritella AV, Messmer MM, Hayashi-Takagi A, Hester LD, Snyder SH, Sawa A, and Sedlak TW. (2011) Glutathione is a physiologic reservoir of neuronal glutamate. Biochem. Biophys Res. Commun. 2011, 409, 596-602.

Sedlak TW, Saleh M, Higginson DS, Paul BD, Juluri KR, and Snyder SH. (2009) Bilirubin and Glutathione:  Complementary Antioxidant and Cytoprotective Roles.  Proc. Natl. Acad. Sci. USA., 106, 5171-5176.

Sedlak TW and Kaplin, AI.  Novel Neurotransmitters:  Nitric Oxide and beyond.  Kaplan & Sadock’s Comprehensive Textbook of Psychiatry, 9^th Edition (2009).  Lippincott Williams & Williams.

Sedlak TW and Snyder SH. (2006) Messenger Molecules and Cell Death: Therapeutic Implications.  JAMA 295, 81-89.

Sedlak TW and Snyder SH. (2004) Bilirubin benefits: Cellular protection by a biliverdin reductase antioxidant cycle.  Pediatrics.  113, 1776-1782.

Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, and Korsmeyer SJ. (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl. Acad. Sci. USA.  92, 7834-7838.