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Sedlak, Thomas W., M.D., Ph.D.

Dr. Thomas Sedlak

Assistant Professor
Director, Adult Schizophrenia Consult Clinic

Schizophrenia Center
Molecular Psychiatry Program
Sedlak Lab

Main Office Address

Meyer 3-166B
Department of Psychiatry and Behavioral Science
Johns Hopkins School of Medicine
600 North Wolfe St.
Baltimore, MD 21287-5371

Phone: 410-614-5995
Fax: 410-614-1792




M.D., Ph.D.

Washington University School of Medicine


Psychiatry Residency/Fellowship

Johns Hopkins University School of Medicine


Board Certification

American Board of Psychiatry and Neurology

Professional Interests

Our laboratory studies brain metabolic and antioxidant pathways relevant to normal brain biology and neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease.

Selected Publications

Koga M, Serritella AV, Messmer MM, Hayashi-Takagi A, Hester LD, Snyder SH, Sawa A, and Sedlak TW. (2011) Glutathione is a physiologic reservoir of neuronal glutamate. Biochem. Biophys Res. Commun. 2011, 409, 596-602.

Sedlak TW, Saleh M, Higginson DS, Paul BD, Juluri KR, and Snyder SH. (2009) Bilirubin and Glutathione:  Complementary Antioxidant and Cytoprotective Roles.  Proc. Natl. Acad. Sci. USA., 106, 5171-5176.

Sedlak TW and Kaplin, AI.  Novel Neurotransmitters:  Nitric Oxide and beyond.  Kaplan & Sadock’s Comprehensive Textbook of Psychiatry, 9th Edition (2009).  Lippincott Williams & Williams.

Sedlak TW and Snyder SH. (2006) Messenger Molecules and Cell Death: Therapeutic Implications.  JAMA 295, 81-89.

Sedlak TW and Snyder SH. (2004) Bilirubin benefits: Cellular protection by a biliverdin reductase antioxidant cycle.  Pediatrics.  113, 1776-1782.

Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, and Korsmeyer SJ. (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl. Acad. Sci. USA.  92, 7834-7838. 


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