Sawa, Akira, M.D., Ph.D.

Professor Director, Johns Hopkins Schizophrenia Center Director, Silvio O. Conte Center for Schizophrenia Research at Johns Hopkins Director, Molecular Psychiatry Program Main Office Address Meyer 3-166A The Johns Hopkins Hospital 600 North Wolfe St. Baltimore, MD 21287 Phone: 410-955-4726 Fax: 410-614-1792 E-mail: asawa1@jhmi.edu Administrative Assistant Yukiko Lema E-mail: ylema1@jhmi.edu Phone: 410-614-5238

Education

Professional Interests

Schizophrenia and bipolar disorder: pathogenesis at the molecular level

• Schizophrenia Center
• Molecular Psychiatry Prgoram

Hopkins BrainWise Newsletter articles about Dr. Sawa's work:

• Schizophrenia: A Sea Change? (Winter 2012)
• Schizophrenia: War to Save Synapses (Fall 2010)
• Toehold on Schizophrenia (Winter 2006)
• Late Blooming Molecule Could Be Key Target ( Spring-Summer 2005)

Selected Publications

 Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N., Kano, S., Ozaki, N., Nabeshima, T., Sawa, A. (2013). Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science, 339, 335-339 [Abstract]

 Coughlin, J.M., Ishizuka, K., Kano, S.I., Edwards, J.A., Seifuddin, F.T., Shimano, M.A., Daley, E.L., Zandi, P.P., Leweke, F.M., Cascella, N.G., Pomper, M.G., Yolken, R.H., and Sawa, A. (2013). Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry 18, 10-11 [Abstract]

 Kano, S., Colantuoni, C., Han, F., Zhou, Z., Yuan, Q., Wilson, A., Takayanagi, Y., Lee, Y., Rapoport, J., Eaton, W., Cascella, N., Ji, H., Goldman, D., and Sawa, A. (2012). Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry AOP [Abstract]

 Golzio, C., Willer, J., Talkowski, M.E., Oh, E.C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J.F., Kamiya, A., Beckmann, J.S., and Katsanis, N. (2012). KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature 485, 363-367 [Abstract]

 Kondo, M., and Sawa, A. (2011). Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act? Cell 147, 964-965 [Abstract]

 Ishizuka, K., Kamiya, A., Oh, E.C., Kanki, H., Seshadri, S., Robinson, J.F., Murdoch, H., Dunlop, A.J., Kubo, K., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M.D., Katsanis, N., and Sawa, A. (2011). DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 473, 92-96 [Abstract]

 Brandon, N.J., and Sawa, A. (2011). Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 12, 707-722 [Abstract]