Main Office Address
Cornell Medical College
Cornell University Graduate School
Baltimore City Hospital
Johns Hopkins Hospital
In their study of neuropsychiatric disorders, Dr. Ross and his research team focus on Huntington's disease and Parkinson's disease, and use insights from these disorders to approach more complex diseases such as schizophrenia. They use biophysical and biochemical techniques, cell models, and transgenic mouse models to understand disease processes and provide targets for development of rational therapeutics. Ultimately, the neurobiologic study of schizophrenia many help illuminate normal thought, perception and emotion – and help us understand the biology of human nature itself.
See Division of Neurobiology and Laboratory of Molecular Neurobiology
Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 2006 Oct 5;52(1):139-53.
Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neurosci. 2006 Oct;9(10):1231-3.
Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18676-81.
Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nature Medicine 2004 Jul;10 Suppl:S10-7.
Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA. Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8.