McInnis, Melvin G., M.D.

Associate Professor

Main Office Address

Meyer 3-166
The Johns Hopkins Hospital
600 North Wolfe Street
Baltimore, MD 21287-5371

Phone: 410-614-0991
Fax: 410-614-1530

E-mail: mmcinnis@jhmi.edu

Administrative Assistant

Irma Rybczynski
E-mail:irybcz1@jhmi.edu

Education

Professional Interests

 Primary research and professional interests are focused on the identification of genes that underlie the susceptibility to mood disorders.  Attempts are being made to associate clinical phenotypes as well as intermediate phenotypes (endophenotypes) with genetically determined genotypes. 

Selected Publications

McInnis, M. G., Chakravarti, A., Blaschak, J., Petersen, M. B., Sharma, V., Avramopoulos, D., Blouin, J. L., Konig, U., Brahe, C., Matise, T. C., Warren, A. C., Talbot, C. C., Van Broeckhoven, C., Litt, M., & Antonarakis, S. E. (1993). A linkage map of human chromosome 21: 43 PCR markers at average intervals of 2.5 cM. Genomics, 16:562-571. 

McInnis, M. G., McMahon, F. J., Chase, G., Simpson, S. G., Ross, C. A., & DePaulo, J. R., Jr. (1993). Anticipation in Bipolar Affective Disorder. American Journal of Human Genetics, 53, 385-390.  

McInnis, M. G. (1996). Anticipation- An Old Idea in New Genes. American Journal of Human Genetics, 59, 973-979.

McInnis, M. G., Breschel, T. S., Margolis, R. L., Chellis, J., Simpson, S. G., MacKinnon, D. F., McMahon, F. J., Lan, T.-H., Chen, H., Ross, C. A., & DePaulo JR Jr. Family-based Association Analysis of the hSKCa3 potassium channel gene in Bipolar Disorder. Molecular Psychiatry 4, 217-219. 1999.  

McInnis, M. G. The Assent of a Nation:  Genethics and Iceland. Clinical Genetics 55, 234-239. 1999.  

McInnis, M. G., Lan, T.-H., Willour, V. L., Zandi, P. P., McMahon, F. J., Simpson, S. G., Addington, A. M., MacKinnon, D. F., Potash, J. B., Mahoney, A. T., Chellis, J., Huo, Y., Swift-Scanlan, T., Chen, H., Koskela, R. J., Stine, O. C., Jamison, K. R., Holmans, P. A., Folstein, S. E., Ranade, K., Friddle, C., Botstein, D., Marr, T., Beaty, T. H., & DePaulo, J. R. Genome-Wide scan of Bipolar Disorder in 65 Pedigrees: Supportive evidence for linkage at 8q24, 18q22, 4q32, 2p13, and 13q14. Molecular Psychiatry 8, 288-298. 2003.