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Margolis, Russell L., M.D.

Dr. Russ Margolis

Professor of Psychiatry and Neurology
Clinical Director, Johns Hopkins Schizophrenia Center
Director, Genetic Neurobiology Laboratory
Co-Director, Division of Neurobiology

Co-Director, Baltimore Huntington’s Disease Center

Main Office Address

Division of Neurobiology
Department of Psychiatry and Behavioral Sciences
CMSC 8-121
The Johns Hopkins Hospital
600 North Wolfe St.
Baltimore, MD 21287-5371

Phone: 410-614-4262
Fax: 443-927-7965


Administrative Assistant

Kathleen Ziolkowski
Phone:  410-614-0014

Education and Government Service



Princeton University



Johns Hopkins University School of Medicine


Medicine-Psychiatry Internship

Francis Scott Key Hospital


Psychiatry Residency

Johns Hopkins


Neurobiology Fellowship

National Institute of Mental Health


Government Service

Public Health Service

Professional Interests

My research interests revolve around the interface of psychiatry, neurology, and genetics.  A major focus is on the etiology, pathogenesis, and psychiatric aspects of neurodegenerative disorders affecting the cerebellum and basal ganglia, including Huntington’s disease, Huntington’s disease-like 2 (discovered by our group), and the cerebellar ataxias.  A second emphasis is on the genetic etiology and pathogenesis of schizophrenia, including the role of rare mutations of major effect, the potential utility of induced pluripotent stem cells as disease models, and novel approaches to mutation detection.  We are particularly interested in the etiologic and pathogenic properties of unstable DNA, RNA toxicity, and bidirectional transcription. My clinical interests include schizophrenia, affective disorders, and neuropsychiatry. 

Click here to learn more about Dr. Margolis' research

Click here for Hopkins Brain Wise Newsletter articles about Dr. Margolis' work

Selected Publications

Holmes SE, O’Hearn E, Callahan C, Hwang HS, Rosenblatt A, Ingersoll-Ashworth RG, Fleisher A, Stevanin G, Brice A, Potter NT, Ross CA, Margolis RL. A CTG trinucleotide repeat expansion in Junctophilin 3 is associated with Huntington's Disease-Like 2 (HDL2).  Nature Genetics, 29 (2001): 377-378.

Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL.  A frameshift mutation in Disrupted in Schizophrenia 1 segregates with schizophrenia and schizoaffective disorder in an American family.  Molecular Psychiatry 10(2005) 758-64

Rudnicki DD, Holmes SE, Lin M, Thorton CA, Ross CA, Margolis RL.  Huntington’s disease-like 2 is associated with CUG repeat containing RNA foci.  Annals of Neurology, 61 (2007):272-82.

Rudnicki DD, Pletnikova O, Vansattel JP, Ross CA, Margolis RL.  A comparison of Huntington’s disease and Huntington’s disease-like 2 neuropathology.  Journal of Neuropathology and Experimental Neurology, 366-74.

Ross CA, Margolis RL. Schizophrenia: A point of disruption. Nature, 458 (2009):976-7


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