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MacKinnon, Dean F., M.D.

Dr. Dean MacKinnon

Associate Professor

Main Office Address

The Johns Hopkins Hospital
Meyer 3-181
600 North Wolfe Street
Baltimore, MD 21287

Phone: 443-287-6330
Fax: 410-955-0152





University of Pennsylvania



University of California, San Diego



Johns Hopkins Bayview (Francis Scott Key)


Psychiatry Residency

Johns Hopkins University


Affective Disorders/Psychiatric Genetics Fellowship

Johns Hopkins University

Professional Interests

My clinical interest is in the evaluation and treatment of patients with complex and treatment refractory depression, manic depressive illness, and anxiety. My research interest revolves around the problem of identifying the phenotypic boundaries of bipolar disorder(s). Specifically, I have identified panic disorder and rapid switching as phenomenological features of bipolar illness that may lead to biologically meaningful subtypes. I am also interested in the psychophysiology of anxiety as it relates to mood disorders. Most of my time and energy for teaching is devoted to running the first year psychiatry course.


Blogs: Psychology Today -  Trouble in Mind

Hopkins BrainWise Newsletter Articles:

Dr. MacKinnon's reseearch

Interview with Dr. MacKinnon about his new book, Trouble in Mind

Selected Publications

MacKinnon, DF, Zamoiski, R. Panic comorbidity with bipolar disorder: what is the manic-panic connection? Bipolar.Disord. Dec (suppl) 2006.

MacKinnon DF, Pies R: Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders. Bipolar.Disord. 2006; 8:1-14

MacKinnon DF, Potash JB, McMahon FJ, Simpson SG, DePaulo JR, Jr., Zandi PP: Rapid mood switching and suicidality in familial bipolar disorder. Bipolar.Disord. 2005; 7:441-448

MacKinnon DF, Zandi PP, Gershon ES, Nurnberger JI, DePaulo JR, Association of rapid mood switching with panic risk in familial bipolar disorder. Am J Psychiatry 2003, 6:1696-8. 

MacKinnon DF, Zandi PP, Gershon ES, Nurnberger JI, Reich T, DePaulo JR, Rapid switching of mood in families with multiple cases of bipolar disorder. Arch Gen Psychiatry, 2003, 9:921-8

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