Ladenheim, Ellen E., Ph.D.

Associate Professor

Main Office Address

Ross 618
720 Rutland Avenue
Baltimore, MD 21205

Phone: 410-614-1750
Fax: 410-502-3769

E-mail: laden@jhmi.edu

Education

Professional Interests

My research interest is in the role of the mammalian bombesin-like peptides in the control of food intake and energy balance. These peptides are found throughout the gastrointestinal tract and brain and reduce food intake in a number of mammalian species, including humans.  An understanding of the mechanisms underlying their effects on feeding could lead to novel therapeutic interventions for obesity or eating disorders.

Selected Publications

Ladenheim, E.E., Jensen, R.T., Mantey, S.A. and Moran, T.H.  Distinct distributions of two bombesin receptor subtypes in the rat central nervous system.  Brain Research 593: 168-178, 1992.

Ladenheim, E.E., Wirth, K.E. and Moran, T.H.  Receptor subtype mediation of feeding suppression by bombesin-like peptides.  Pharmacol. Biochem. Behav. 54:504:705-711, 1996. 

Ladenheim, E.E., Moore, K.A., Salorio, C.F., Mantey, S.A., Taylor, J.E., Coy, D.H., Jensen, R.T. and Moran, T.H.  Characterization of bombesin binding sites in the rat stomach.  Eur. J. Pharmacol. 319:245-251, 1997. 

Ladenheim, E.E., Wohn, A. White, W.O., Schwartz, G.J. and Moran, T.H.  Inhibition of gastric emptying by bombesin-like peptides is dependent upon cholecystokinin-A receptor activation.  Regulatory Peptides, 84:101-106, 1999. 

Ladenheim, E.E., Hampton, L.L., Whitney, A.C., White, W.O., Battey, J.F. and Moran, T.H.  Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice.  J. Endocrinol. 174:273-281, 2002.

Ladenheim EE, Emond M, Moran, TH: Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin. American Journal of Physiology 2005:289:473-477.