Jaaro-Peled, Hanna., Ph.D.

Instructor Schizophrenia Center Program in Molecular Psychiatry Main Office Address Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Osler 3-149 600 North Wolfe Street Baltimore MD 21287 Phone: 443-287-1868 Fax: 410-614-1792 E-mail: hjaarop1@jhmi.edu

Education

Professional Interests

Study the biology of schizophrenia and other psychiatric disorders using mouse models based on genetic risk factors

Selected Publications

Lin CY, Sawa A, Jaaro-Peled H. Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models. Neurobiol Dis. 2012, 45:48-56.  Link

Jaaro-Peled H, Ayhan Y, Pletnikov MV, Sawa A. Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and non-genetic models. Schizophr Bull. 2010, 36:301-313 Link

Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron  2010, 65:480-489. Link

Jaaro-Peled H. Gene models of schizophrenia: DISC1 mouse models. Prog Brain Res. 2009, 179:75-86. Link

Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci. 2009, 32:485-495. Link

^*Hikida T, ^*Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka M, Pletnikov M, Kida S, Sawa A. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A. 2007, 14501-14506. Link

*These authors contributed equally to this work.