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Duan, Wenzhen, M.D., Ph.D.

Dr. Wenzhen Duan

Associate Professor
Director, Translational Neurobiology Laboratory

Main Office Address

The Johns Hopkins Hospital
CMSC 9-111
600 N. Wolfe Street
Baltimore, MD 21287

Phone: 410-502-2866
Fax: 410-614-0013

E-mail: wduan2@jhmi.edu


Administrative Assistant

Debbie Stroback
E-mail : debbi@jhu.edu

Education

1992

M.D.

Shanxi Medical University (PR China)

1998

Ph.D.

Peking Union Medical University (PR China)

1998-2000

Post-Doctoral Fellowship 

University of Kentucky

Professional Interests

Dr. Duan and her team use multidisciplinary approaches to elucidate molecular mechanisms and  develop therapeutic targets for Huntignton’s disease and Parkinson’s disease.

Selected Publications

Duan W, Guo ZH, Jiang HY, Ware M, Li  XJ, Mattson MP. Dietary Restriction Normalizes Glucose Metabolism and BDNF Levels, Slows Disease Progression and Increases Survival in Huntingtin Mutant Mice. Proc. Natl. Acad. Sci. U S A 2003;100(5):2911-6.

Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA. Sertraline Slows Disease Progression and Increases Neurogenesis in N171-82Q mouse model of Huntington's Disease. Neurobio Dis, 2008;30: 312-322.

Masuda N, Peng Q, Li Q, Jiang M, Liang Y, Wang X, Zhao M, Wang W, Ross CA, Duan W. Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease. Neurobio Dis, 2008; 30:293-302.

Zhang J, Peng Q, Li Q, Jahanshad N, Hou Z, Jiang M, Masuda N, Langbehn DR, Miller MI, Mori S, Ross CA, Duan W. Longitudinal characterization of brain atrophy of a Huntington’s disease mouse model by automated morphological analyses of magnetic resonance images. Neuroimage, 2010,49:2340-2351.

Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack D, Poirier MA, Ross CA, Duan W.  Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.  J Neurochem, 2010, April 19, 114:419-429.




 

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