Duan, Wenzhen, M.D., Ph.D.

Assistant Professor Director, Translational Neurobiology Laboratory Main Office Address The Johns Hopkins Hospital CMSC 9-111 600 N. Wolfe Street Baltimore, MD 21287 Phone: 410-502-2866 Fax: 410-614-0013 E-mail: wduan2@jhmi.edu Administrative Assistant Eileen Kasda E-mail : ekasda1@gw.johnshopkins.edu

Education

Professional Interests

Therapeutic development in Huntington's disease and Parkinson's disease

Selected Publications

Duan W, Zhu X, Ladenheim B, Yu QS, Guo ZH, Olyer J,Cutler RG, Cadet JL, Greig NH and Mattson MP . Synthetic p53 Inhibitors Preserve Dopaminergic Neurons and Motor Function in Experimental Parkinsonism. Ann Neurol 2002 ; 52:597-606.

Duan W, Guo ZH, Jiang HY, Ware M, Li XJ, Mattson MP. Dietary Restriction Normalizes Glucose Metabolism and BDNF Levels, Slows Disease Progression and Increases Survival in Huntingtin Mutant Mice. Proc. Natl. Acad. Sci. U S A 2003 Mar 4;100(5):2911-6.

Duan W, Guo ZH, Jiang H, Ware M, Mattson MP. Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology 2003, Jun;144(6):2446-53.

Duan W, Guo Z, Jiang H, Ladenheim B, Xu X, Cadet JL, Mattson MP. Paroxetine retards disease onset and progression in Huntingtin mutant mice. Ann Neurol 2004, 55(4):590-4.

Wang W, Duan W, Igarashi S, Morita H, Nakamura M, Ross CA. Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model. Neurobiol Dis. 2005,20(2):500-8.