Duan, Wenzhen, M.D., Ph.D.

Associate Professor Director, Translational Neurobiology Laboratory Main Office Address The Johns Hopkins Hospital CMSC 9-111 600 N. Wolfe Street Baltimore, MD 21287 Phone: 410-502-2866 Fax: 410-614-0013 E-mail: wduan2@jhmi.edu Administrative Assistant Debbie Stroback E-mail : debbi@jhu.edu

Education

Professional Interests

Dr. Duan and her team use multidisciplinary approaches to elucidate molecular mechanisms and  develop therapeutic targets for Huntignton’s disease and Parkinson’s disease.

Selected Publications

Duan W, Guo ZH, Jiang HY, Ware M, Li  XJ, Mattson MP. Dietary Restriction Normalizes Glucose Metabolism and BDNF Levels, Slows Disease Progression and Increases Survival in Huntingtin Mutant Mice. Proc. Natl. Acad. Sci. U S A 2003;100(5):2911-6.

Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA. Sertraline Slows Disease Progression and Increases Neurogenesis in N171-82Q mouse model of Huntington's Disease. Neurobio Dis, 2008;30: 312-322.

Masuda N, Peng Q, Li Q, Jiang M, Liang Y, Wang X, Zhao M, Wang W, Ross CA, Duan W. Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease. Neurobio Dis, 2008; 30:293-302.

Zhang J, Peng Q, Li Q, Jahanshad N, Hou Z, Jiang M, Masuda N, Langbehn DR, Miller MI, Mori S, Ross CA, Duan W. Longitudinal characterization of brain atrophy of a Huntington’s disease mouse model by automated morphological analyses of magnetic resonance images. Neuroimage, 2010,49:2340-2351.

Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack D, Poirier MA, Ross CA, Duan W.  Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.  J Neurochem, 2010, April 19, 114:419-429.