Bi, Sheng, M.D.

Associate Professor Main Office Address Ross 618 720 Rutland Avenue Baltimore, MD 21205 Phone: 410-502-4789 Fax: 410-502-3769 E-mail: sbi@jhmi.edu

Education

Professional Interests

My research interests focus on the hypothalamic neural systems underlying energy homeostasis. We currently have two major projects. The first is aimed at characterizing dorsomedial hypothalamic (DMH) neural pathways and identifying how DMH peptide signaling affects food intake and body weight. The second project is aimed at ascertaining the hypothalamic peptide signaling that mediates the effects of exercise on food intake and energy balance.

Selected Publications

Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, Bi S.  Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci.  29(1):179-90, 2009.

Chen J, Scott KA, Zhao Z, Moran TH, Bi S.  Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration.  Neuroscience  152:178–188, 2008.

Bi S, Chen J, Behles RR, Hyun J, Kopin A, Moran TH.  Differential body weight and feeding responses to high fat diets in rats and mice lacking cholecystokinin 1 receptors.  Am J Physiol Regul Integr Comp Physiol. 293(1):R55-63, 2007.

Kawaguchi M, Scott KA, Moran TH, Bi S. Dorsomedial hypothalamic corticotropin-releasing factor (CRF) mediation of exercise-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 288:R1800-5, 2005.

Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH.  Running wheel activity prevents hyperphagia and obesity in OLETF rats: role of hypothalamic signaling.  Endocrinology  146:1676-85, 2005.