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Joseph Califano, III, M.D.

Joseph A. Califano, III, M.D.
Professor of Otolaryngology - Head and Neck Surgery


Appointment Phone


Main Location

Johns Hopkins Head and Neck Surgery - GBMC

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Professor of Otolaryngology - Head and Neck Surgery
  • Professor of Oncology

Centers & Institutes



Johns Hopkins Head and Neck Surgery - GBMC

Appointment Phone: 443-849-8940

6569 N. Charles Street
Physicians Pavilion West Suite 401
Towson, MD 21204 map
Phone: 443-849-8940
Fax: 443-849-8902


Head and Neck Cancers, Head and Neck Surgery, Head and Neck Tumors, Laryngeal Cancer, Minor Salivary Gland Cancers, Oral Cancers, Oral Cavity Cancers, Oropharynx Cancers, Otolaryngology, Robotic Surgery, Salivary Gland Tumors, Skull Base Surgery, Throat Cancer, Thyroid Cancer

Research Interests

Molecular biologic basis of head and neck cancer and premalignant lesions; Genetic alterations in premalignant lesions, and molecular detection and surveillance; tumor immunology; molecular targeted therapies


Dr. Califano earned his medical degree from Harvard University, completed his residency at Johns Hopkins Hospital and his fellowship at Memorial Sloan-Kettering Cancer Center. He is a practicing head and neck surgeon with an interest in salivary gland tumors, cancers of the mouth, throat, larynx, sinuses, thyroid, and skull base. He is active investigator who described the initial genetic progression model for head and neck cancer development. He is currently the principal investigator of multiple multi-institutional trials focused on head and neck squamous cell carcinoma and premalignant disease of the head and neck. His current laboratory research interests include the molecular biologic basis of head and neck cancer development, with a particular interest in molecular alterations in premalignant lesions, epigenetic regulation, mitochondrial dysregulation, as well as molecular detection and surveillance. more

    Additional Information

  • Education +
    • B.A., Amherst College (Massachusetts) (1985)
    • M.D., Harvard Medical School - Boston (Massachusetts) (1993)
  • Research & Publications +

    Selected Publications

    Glazer CA, Smith IM, Bhan S, Sun W, Chang SS, Pattani KM, Westra W, Khan Z, Califano JA. The Role of MAGEA2 in Head and Neck Cancer. Arch Otolaryngol Head
    Neck Surg. 2011 Mar;137(3):286-93. PubMed PMID: 21422315

    Hao Y, Gu X, Zhao Y, Greene S, Sha W, Smoot D, Califano JA, Wu TC, Pang X. Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating
    cyclooxygenase-2 pathway in vivo. Cancer Prev Res (Phila). 2011 Mar 23. [Epub ahead of print] PubMed PMID: 21430074

    Singhi AD, Califano J, Westra WH. High-risk human papillomavirus in nasopharyngeal carcinoma. Head Neck. 2011 Apr 11. doi: 10.1002/hed.21714. [Epubahead of print] PubMed PMID: 21484924

    Johnson NW, Warnakulasuriya S, Gupta PC, Dimba E, Chindia M, Otoh EC, Sankaranarayanan R, Califano J, Kowalski L. Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Adv Dent Res. 2011
    May;23(2):237-46. PubMed PMID: 21490236

    Guerrero-Preston R, Soudry E, Acero J, Orera M, Moreno-Lpez L, Maca-Coln G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry RA, Esteller M, Westra W, Koch W, Califano J, Sidransky D. NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva. Cancer Prev Res (Phila). 2011 Jul;4(7):1061-72. Epub 2011 May 10. PubMed PMID: 21558411; PubMed Central PMCID: PMC3131432.

    Bhan S, Negi SS, Shao C, Glazer CA, Chuang A, Gaykalova DA, Sun W, Sidransky D, Ha PK, Califano JA. BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer. Clin Cancer Res. 2011 Jul 1;17(13):4267-76. Epub 2011 May 10. PubMed PMID: 21558405.

    Shao C, Sun W, Tan M, Glazer CA, Bhan S, Zhong X, Fakhry C, Sharma R, Westra WH, Hoque MO, Moskaluk CA, Sidransky D, Califano JA, Ha PK. Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res. 2011 Jul 1;17(13):4320-30. Epub 2011 May 6. PubMed PMID: 21551254; PubMed Central PMCID: PMC3131484.

    Hennessey PT, Ochs MF, Mydlarz WW, Hsueh W, Cope L, Yu W, Califano JA. Promoter methylation in head and neck squamous cell carcinoma cell lines is significantly different than methylation in primary tumors and xenografts. PLoS One. 2011;6(5):e20584. Epub 2011 May 26. PubMed PMID: 21637785; PubMed Central PMCID: PMC3102742.

    Pattani KM, Califano J. Long-Term Experience in Sentinel Node Biopsy for Early Oral and Oropharyngeal Squamous Cell Carcinoma. Ann Surg Oncol. 2011 May 17. [Epub ahead of print] PubMed PMID: 21584830.

    Begum S, Brait M, Dasgupta S, Ostrow KL, Zahurak M, Carvalho AL, Califano JA, Goodman SN, Westra WH, Hoque MO, Sidransky D. An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA. Clin Cancer Res. 2011 Jul 1;17(13):4494-4503. Epub 2011 May 24. PubMed PMID: 21610147; PubMed Central PMCID: PMC3131425.

    Carvalho AL, Henrique R, Jeronimo C, Nayak CS, Reddy AN, Hoque MO, Chang S, Brait M, Jiang WW, Kim MM, Claybourne Q, Goldenberg D, Khan Z, Khan T, Westra WH, Sidransky D, Koch W, Califano JA. Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance. Clin Cancer Res. 2011 Jul 12. [Epub ahead of print] PubMed PMID: 21628494.

    Mithani SK, Smith IM, Califano JA. Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. Melanoma Res. 2011 Aug;21(4):298-307. PubMed PMID: 21606880; PubMed Central PMCID: PMC3131489.

    Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Trevio L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1. Science. 2011 Aug 26;333(6046):1154-1157. Epub 2011 Jul 28. PubMed PMID: 21798897.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • American Academy of Otolaryngology-Head and Neck Surgery
    • American Association for Cancer Research
    • American Association for the Advancement of Science
    • American College of Surgeons
    • American Head and Neck Society (AHNS)
    • International Academy of Oral Oncology
      Councilor and Founding Fellow
    • Massachusetts Medical Society
  • Videos & Media +
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