Dr. Miguel A. Aon was born and raised in Argentina. He received a Masters in Agronomic Engineering (1980) and a Ph.D. in Chemical Sciences (1986), both from the Universidad Nacional de Córdoba, Argentina.
At present Dr. Aon is Assistant Professor of Medicine at Johns Hopkins University. His scientific expertise spans the areas of non-linear dynamics, mathematical modeling of biological systems and, more specifically, quantitative analysis of metabolism, mitochondrial and cellular biology as applied to cardiobiology and cardiac function. At present Dr. Aon studies the role of mitochondrial dysfunction in diabetic cardiomyopathy. Dr. Aon’s expertise, contributions, and mastery of these fields are reflected in two books titled: Dynamic Biological Organization in coauthorship with Dr. Cortassa (1997, Chapman & Hall, London), and An Introduction to Metabolic and Cellular Engineering with Dr. Cortassa, Dr. Lloyd, Dr. Iglesias, and Dr. Juan C. Aon (1st edition in 2002 and 2nd ed. in 2012, World Scientific, Singapore).
Cortassa, S., Aon, M. A., Marban, E., Winslow, R. L. and O'Rourke, B. (2002) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J., 84: 2734-2755.
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Cortassa, S., M. A. Aon, et al. (2004). "A mitochondrial oscillator dependent on reactive oxygen species." Biophys. J. 87(3): 2060-2073.
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Akar, F.G.,* Aon, M.A. ,*Tomaselli, G.F. and O'Rourke, B.(2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest. 115, 3527-3535.(*Equal contribution)
Aon, M.A.,Cortassa, S., Akar, F.G. and O'Rourke, B.(2006) Mitochondrial criticality: A new concept at the turning point of life or death. Biochim. Biophys. Acta 1762, 232-240. Review article.
Cortassa, S., Aon, M.A., O'Rourke, B., Jacques, R., Tseng, H.-J., Marbán, E., and Winslow, R.L. (2006) A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte. Biophys. J. 91, 1564-1589.
Aon, M.A., Cortassa, S., and O'Rourke, B. (2006) The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys. J. 91: 4317-4327.
Cortassa, S, O'Rourke, B, Winslow, R.L., Aon, M.A. (2009) Control and Regulation of Mitochondrial Energetics in an Integrated Model of Cardiomyocyte Function. Biophys. J. 96: 2466-2478.
Stanley, B.A., Sivakumaran, V., Shi, S., McDonald, I., Lloyd, D., Watson, W.H., Aon, M.A., *Paolocci, N.*(2011) Thioredoxin Reductase-2 is essential for keeping low levels of H2O2emission from isolated heart mitochondria. J. Biol. Chem. 286: 33669-33677 (*Equal contribution)
Cortassa, S., Aon, M.A. (2012) Computational modeling of mitochondrial function. Methods in Molecular Biology 810: 311-326.
Cortassa, S., Aon, M.A., Iglesias, A.A., Aon, J.C. and Lloyd, D. (2012) An Introduction to Metabolic and Cellular Engineering. World Scientific Publishers, Singapore. 2nd Edition, 448 pp.
Tocchetti, CG, Caceres, V., Stanley, BA, Xie, Ch, Shi, S, Watson, WH, O'Rourke B, Spadari-Bratfisch, RC, Cortassa, S, Akar, FG, Paolocci, N,* Aon, M.A. * (2012) GSH or palmitate preserves mitochondrial energetic/redox balance preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes 61: 3094-3105 (* Equal contribution)
Microscopy/Confocal Imaging Core