Skip Navigation
Find a Doctor
 
 
 
 

 

Photo of Dr. Miguel Aon

Miguel Antonio Aon, Ph.D.

Assistant Professor
Assistant Professor of Medicine
Male

Titles

  • Assistant Professor
  • Assistant Professor of Medicine

Research Interests

Mitochondrial dysfunction in diabetes

Technology Expertise

Two-photon laser scanning fluorescence microscopy, computational modeling,

Biography

Dr. Miguel A. Aon was born and raised in Argentina. He received a Masters in Agronomic Engineering (1980) and a Ph.D. in Chemical Sciences (1986), both from the Universidad Nacional de Córdoba, Argentina.

At present Dr. Aon is Assistant Professor of Medicine at Johns Hopkins University. His scientific expertise spans the areas of non-linear dynamics, mathematical modeling of biological systems and, more specifically, quantitative analysis of metabolism, mitochondrial and cellular biology as applied to cardiobiology and cardiac function. At present Dr. Aon studies the role of mitochondrial dysfunction in diabetic cardiomyopathy. Dr. Aon's expertise, contributions, and mastery of these fields are reflected in two books titled: Dynamic Biological Organization in coauthorship with Dr. Cortassa (1997, Chapman & Hall, London), and An Introduction to Metabolic and Cellular Engineering with Dr. Cortassa, Dr. Lloyd, Dr. Iglesias, and Dr. Juan C. Aon (1st edition in 2002 and 2nd ed. in 2012, World Scientific, Singapore).

Languages

  • English
Additional Resources +
  • Education +

    Education

    • Ph.D., Universidad Nacional de Cordoba, 1986, Chemical Sciences

    Fellowships

    • E.C. Slater Institute for Biochemical Research, University of Amsterdam, The Netherlands, 1990
    • Laboratoire de Technologie Enzymatique, France, 1989
    • National Research Council (CONICET), Argentina, 1986
  • Research & Publications +

    Research Summary

    Dr. Miguel A. Aon was born and raised in Argentina. He received a Masters in Agronomic Engineering (1980) and a Ph.D. in Chemical Sciences (1986), both from the Universidad Nacional de Córdoba, Argentina.

    At present Dr. Aon is Assistant Professor of Medicine at Johns Hopkins University. His scientific expertise spans the areas of non-linear dynamics, mathematical modeling of biological systems and, more specifically, quantitative analysis of metabolism, mitochondrial and cellular biology as applied to cardiobiology and cardiac function. At present Dr. Aon studies the role of mitochondrial dysfunction in diabetic cardiomyopathy. Dr. Aon’s expertise, contributions, and mastery of these fields are reflected in two books titled: Dynamic Biological Organization in coauthorship with Dr. Cortassa (1997, Chapman & Hall, London), and An Introduction to Metabolic and Cellular Engineering with Dr. Cortassa, Dr. Lloyd, Dr. Iglesias, and Dr. Juan C. Aon (1st edition in 2002 and 2nd ed. in 2012, World Scientific, Singapore).

    Selected Publications

    Cortassa, S., Aon, M. A., Marban, E., Winslow, R. L. and O'Rourke, B. (2002) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J., 84: 2734-2755.
    View on Pubmed

    Cortassa, S., M. A. Aon, et al. (2004). "A mitochondrial oscillator dependent on reactive oxygen species." Biophys. J. 87(3): 2060-2073.
    View on Pubmed

    Akar, F.G.,* Aon, M.A. ,*Tomaselli, G.F. and O'Rourke, B.(2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest. 115, 3527-3535.(*Equal contribution)

    Aon, M.A.,Cortassa, S., Akar, F.G. and O'Rourke, B.(2006) Mitochondrial criticality: A new concept at the turning point of life or death. Biochim. Biophys. Acta 1762, 232-240. Review article.

    Cortassa, S., Aon, M.A., O'Rourke, B., Jacques, R., Tseng, H.-J., Marbán, E., and Winslow, R.L. (2006) A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte. Biophys. J. 91, 1564-1589.

    Aon, M.A., Cortassa, S., and O'Rourke, B. (2006) The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys. J. 91: 4317-4327.

    Cortassa, S, O'Rourke, B, Winslow, R.L., Aon, M.A. (2009) Control and Regulation of Mitochondrial Energetics in an Integrated Model of Cardiomyocyte Function. Biophys. J. 96: 2466-2478.

    Stanley, B.A., Sivakumaran, V., Shi, S., McDonald, I., Lloyd, D., Watson, W.H., Aon, M.A., *Paolocci, N.*(2011) Thioredoxin Reductase-2 is essential for keeping low levels of H2O2emission from isolated heart mitochondria. J. Biol. Chem. 286: 33669-33677 (*Equal contribution)

    Cortassa, S., Aon, M.A. (2012) Computational modeling of mitochondrial function. Methods in Molecular Biology 810: 311-326.

    Cortassa, S., Aon, M.A., Iglesias, A.A., Aon, J.C. and Lloyd, D. (2012) An Introduction to Metabolic and Cellular Engineering. World Scientific Publishers, Singapore. 2nd Edition, 448 pp.

    Tocchetti, CG, Caceres, V., Stanley, BA, Xie, Ch, Shi, S, Watson, WH, O'Rourke B, Spadari-Bratfisch, RC, Cortassa, S, Akar, FG, Paolocci, N,* Aon, M.A. * (2012) GSH or palmitate preserves mitochondrial energetic/redox balance preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes 61: 3094-3105 (* Equal contribution)

    CORE Facilities

    Microscopy/Confocal Imaging Core

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    1989-91 Science and Technology Grant of the Commission of the European Communities to Aon, Miguel A. to perform studies on microbial growth and metabolism at the University of Amsterdam, The Netherlands, 1989-91.

    1995-96 Alexander von Humboldt Foundation fellowship to Aon, Miguel A. to perform studies on yeast cell cycle and catabolite repression at the University of Frankfurt, Germany,

    2005   Melvin L. Marcus Young Investigator Award in Cardiovascular Science. Akar, F.G., Aon, M.A., Tomaselli, G.F., O'Rourke, B. Work presented by Akar, F.G. Scientific Sessions 2005. November 2005, Dallas, Texas.

    Professional Activities

    2010- Associate Editor for Frontiers in Physiology

    Aon, M.A., Saks, V., Schlattner, U., Editors (2013) 

    Systems Biology of Metabolic and Signaling Networks. Springer-Verlag (in the press)

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Department/Division

    • Medicine - Cardiovascular

    For Research Inquiries Contact

    Phone:  410-955-2759 Fax:  410-502-5055 1059 Ross Building 720 Rutland Avenue Baltimore, MD   21205

Is This You? Edit Profile

 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer