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Photo of Dr. Atsushi Kamiya

Atsushi Kamiya, M.D., Ph.D.

Assistant Professor of Psychiatry and Behavioral Sciences
Male

Titles

  • Assistant Professor of Psychiatry and Behavioral Sciences

Centers & Institutes

  • Molecular Psychiatry Program
  • Schizophrenia Center

Research Interests

Gene-environment interactions in brain development; Genetic risk factors

Languages

  • English
Additional Resources +
  • Education +

    Education

    • M.D., Shiga University of Medical Science, Shiga, Japan, 1996
    • Ph.D., Shiga University of Medical Science, Shiga, Japan, 2006

    Training

    • Shiga University Hospital, Toyosato Hospital, Toyosato, Japan, 2000, Residency
    • Shiga University of Medical Science, Shiga, Japan, 2002, Staff Psychiatrist

    Fellowships

    • Johns Hopkins University School of Medicine, Baltimore, Maryland, 2007, Psychiatry
  • Research & Publications +

    Research Summary

    The ultimate goal of our research is to understand the molecular mechanisms of mental disorders, such as schizophrenia and other associated neuropsychiatric conditions, which may eventually lead to new therapeutic strategies. Recently, there has been significant progress in determining the mechanisms whereby many genetic risk factors impact brain development. Nonetheless, given that the majority of psychiatric disorders have etiological complexities encompassing multiple risk genes and environmental factors, the biological mechanisms of these diseases remain poorly understood. 

    By employing a multidisciplinary approach, such as genetics, biochemistry, molecular biology, and conditional gene targeting, including in utero electroporation, my laboratory is able to advance understanding of disease mechanisms. We examine how genetic risk factors during brain development may influence neuronal circuit maturation and resultant behaviors. We also investigate how environmental factors and genetic risk factors interact to affect brain development and function.

    Selected Publications

    1. Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, O., Okawa, M., Ross, C.A., Hatten, M.E., Nakajima, K., Sawa, A.: A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.  Nature Cell Biol., 7; 1167-1178 (2005)  (highlighted as “ 10 major breakthroughs in 2005 in Science 310: 1880-1885 2005”) 
    2. Kamiya, A., Tan, P.L., Kubo, K., Engelhard, C., Ishizuka, K., Kubo, A., Tsukita, S.,  Pulver, A. E., Nakajima, K., Cascella, N. G., Katsanis, N., Sawa, A.: PCM1 is recruited to the centrosome by the cooperative action of DISC1 and BBS4 and is a candidate for psychiatric illness.  Arch. Gen. Psychiatry 65; 996-1006 (2008)
    3. Niwa, M.*Kamiya, A*., Murai, R., Kubo, K., Gruber, A., Lu, L., Seshadri, S., Hiyama, H., Jaaro-Peled, H., Noda, Y., Cascella, N., O’donnell, P., Nakajima, K., Sawa, A., Nabeshima, T.: Transient knockdown of DISC1 in the developing cerebral cortex leads to dopaminergic disturbance and schizophrenia deficits in young adult mice.  *These authors contributed equally to this work.  Neuron65; 480-489 (2010)   
    4. Zoubovsky, SP, Pogorelov, VM, Taniguchi, Y, Kim, S, Yoon, P, Nwulia, E, Sawa, A, Pletnikov, MV,Kamiya, A.: Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function.  Biochem Biophys Res Commun 408; 707-712 (2011). 
    5. Taniguchi, Y, Young-Pearse, T, Sawa, A, Kamiya, A.In utero electroporation as a tool for genetic manipulation in vivo in order to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist 18;169-79 (2012). 
    6. Saito, A., Ballinger, M., Pletnikov, MV., Wong, DF., Kamiya, A.: Endocannabinoid system: potential novel targets for treatment of schizophrenia.  Neurobiology of Disease 53; 10-17 (2013)

    Lab

    Learn about the lab HERE

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  • Contact & Locations +

    Department/Division

    • Psychiatry and Behavioral Sciences

    For Research Inquiries Contact

    Department of Psychiatry and Behavioral Sciences
    Johns Hopkins University School of Medicine
    600 North Wolfe Street Meyer 3-146
    Baltimore MD 21287

    Phone : 410-502-0060
    Fax: 410-614-1792
    E-mail: akamiya1@jhmi.edu

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