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Photo of Dr. Anobel Tamrazi, M.D., Ph.D.

Anobel Tamrazi, M.D., Ph.D.

Assistant Professor of Radiology in the Division of Vascular and Interventional Radiology
Assistant Professor of Radiology and Radiological Science

Male  | Languages: English, Assyrian, Persian

Appointment Phone

410-955-6500

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Assistant Professor of Radiology in the Division of Vascular and Interventional Radiology
  • Assistant Professor of Radiology and Radiological Science

Departments

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-955-6500

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-6500

Johns Hopkins Medicine - Green Spring Station

10755 Falls Road
Pavilion I
Lutherville, MD 21093 map
Phone: 410-583-2700

Johns Hopkins Medicine - White Marsh

4924 Campbell Boulevard
Nottingham, MD 21236 map
Phone: 443-442-2400

Expertise

Diagnostic Radiology

Research Interests

As a doctoral student, Dr. Tamrazi helped develop protein based molecular sensors in evaluating the structure and function of Estrogen Receptors for in vitro drug screening of potential small molecules for the treatment of Breast Cancer. Subsequently, as a medical student and resident, he expanded on that research while working with Dr. Gambhir and the Molecular Imaging Program at Stanford to develop bioluminescence based molecular sensors for imaging of nuclear hormone receptors in living small animals. Dr. Tamrazi is focused on innovation through combining his background in basic science research and his clinical practice as an Interventional Radiologist. He is most interested in pursuing new molecular interventions as they relate to Interventional Oncology. His current research focus includes the locoregional delivery of novel molecular targeting agents (RNA, small molecules) for the treatment of hepatobiliary cancers

Biography

Dr. Anobel Tamrazi is an Assistant Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. His area of clinical expertise is diagnostic radiology.

Dr. Tamrazi earned his undergraduate degree from San Jose State University and received his M.D. and Ph.D. in chemistry from University of Illinois at Urbana-Champaign. He completed his residency at Stanford University School of Medicine and performed a fellowship in interventional radiology at Stanford University Medical Center.

Dr. Tamrazi joined the Johns Hopkins faculty in 2013.

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    Additional Information

  • Education +

    Degrees

    • University of Illinois at Champaign-Urbana / MD (2007)

    Residencies

    • Stanford University School of Medicine / Radiology (2012)

    Fellowships

    • Stanford University Medical Center / Interventional Radiology (2013)

    Certifications

    • American Board of Radiology / Diagnostic Radiology (2012, 2014)
  • Research & Publications +

    Selected Publications

    PEER-REVIEWED PUBLICATIONS:

    1. Tamrazi A and Vasanawala S S. Functional hepatobiliary MR imaging in children. Pediatric Radiology. 41: 1250-1258 (2011).

    2. Paulmurugan R, Tamrazi A, Massoud T F, Katzenellenbogen J A, and Gambhir S S. In Vitro and In Vivo Molecular Imaging of Estrogen Receptor alpha and beta homo- and hetero-dimerization: Exploration of new modes of receptor regulation. Molecular Endocrinology. 25(12): 2029-2040 (2011).

    3. Young P M, Brau A C, Iwadate Y, Vasanawala S S, Daniel B L, Tamrazi A, and Herfkens R J. Respiratory-navigated free breathing 3D-spoiled gradient echo sequence for contrast-enhanced examination of the liver: Diagnostic utility and comparison with free breathing and breath-hold conventional exams. American Journal of Roentgenology. 195(3): 687-691 (2010).

    4. Paulmurugan R, Tamrazi A, Katzenellenbogen J A, Katzenellenbogen B S, and Gambhir S S. A human estrogen receptor (ER) alpha mutation with differential responsiveness to nonsteroidal ligands: Novel approaches for studying mechanism of ER action. Molecular Endocrinology. 22(7): 1552-1564 (2008).

    5. Benyamin R, Vallejo R, Yousuf N, Tamrazi A, and Kramer J. Incidental diagnosis of intradural lumbar disc herniation during discography: A case report. Pain Practice. 7(4): 332-336 (2007).

    6. Tamrazi A, Carlson K E, Rodrigeuz A L, and Katzenellenbogen J A. Coactivator proteins as determinants of estrogen structure and function: Spectroscopic evidence for a novel coactivator-stabilized receptor conformation. Molecular Endocrinology. 19(6): 1516-1528 (2005).

    7. Kim S H, Tamrazi A, Carlson K E, and Katzenellenbogen J A. A proteomic microarray approach for exploring ligand-initiated nuclear hormone receptor pharmacology, receptor selectivity, and hetero-dimer functionality. Molecular and Cellular Proteomics. 4(3): 267-277 (2005).

    8. Kim S H, Tamrazi A, Carlson K E, Daniels J R, Lee I Y, and Katzenellenbogen J A. Estrogen receptor microarray: Subtype-selective ligand binding. Journal of American Chemical Society. 126(15): 4754-4755 (2004).

    9. Hurth K M, Nilges M J, Carlson K E, Tamrazi A, Belford R L, and Katzenellenbogen J A. Ligand-induced changes in estrogen receptor conformations as measured by site-directed spin labeling. Biochemistry. 43(7): 1891-1907 (2004).

    10. Rodriguez A L, Tamrazi A, Collins M L, and Katzenellenbogen J A. Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding. Journal of Medicinal Chemistry. 47(3): 600-611 (2004).

    11. Tamrazi A and Katzenellenbogen J A. Site-specific fluorescent labeling of estrogen receptors and structure-activity relationships of ligands in terms of receptor dimer stability. Methods in Enzymology. 364: 37-53 (2003).

    12. Tamrazi A, Carlson K E, and Katzenellenbogen J A. Molecular sensors of estrogen receptor conformations and dynamics. Molecular Endocrinology. 17(12): 2593-2602 (2003).

    13. Tamrazi A. Fluorescent-labeled Estrogen Receptors: Molecular sensors of receptor structure and function. PhD Dissertation, University of Illinois at Urbana, 2003.

    14. Tamrazi A, Carlson K E, Daniels J R, Hurth K M, and Katzenellenbogen J A. Estrogen receptor dimerization: Ligand binding regulated dimer affinity and dimer dissociation rate. Molecular Endocrinology. 16(12): 2706-2719 (2002).

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Pines Travel Award, Organic Chemistry Department at University of Illinois, 2001
    • Seemon-Pines Award, Annual University of Illinois Organic Chemistry Allerton Conference, 2001
    • Travel Grant Award, The Endocrine Society , 2001
    • R.C. Fuson Memorial Travel Fund, University of Illinois, 2003
    • First Place Medical Student Winner for clinical vignette poster, American College of Physicians Illinois Chapter Meeting, 2005
    • Swartz-Flood Award for best student presentation, 25th Annual University of Illinois Medical Scholars Program Allerton Conference, 2005
    • Daniel K. and Frances A. Bloomfield Fellowship, University of Illinois Medical Scholars Program, 2007
    • Honor Society Award, Alpha Omega Alpha , 2007
    • Honor Society Award, Gold Humanism , 2007
    • Chief Resident, Stanford Radiology; Stanford, 2010 - 2011
    • Consultant of the Year, Stanford Emergency Department; Stanford, 2010 - 2011

    Memberships

    • Alpha Omega Alpha Society
    • American Chemical Society
    • Society of Interventional Radiology Radiological Society of North America
  • Videos & Media +

    Lectures and Presentations

    Image-Guided Tumor Targeted Delivery (IGTD)
    NCI Workshop , Bethesda, MD (11/01/2010)

    Pictures of a Pandemic: A pediatric ICU case review series of H1N1 Influenza A
    Oral presentation, European Society of Pediatric Radiology , Bordeaux, France (06/01/2010)

    Fluorophore-labeled estrogen receptors: Molecular sensors of receptor conformation and conformational dynamics
    225th American Chemical Society National Meeting , New Orleans, LA (03/23/2003)

    Functional fluorescent estrogen receptors (ER): Homo- and hetero-dimerization, coregulator recruitment and site-specific regional dynamics of ER-Ligand binding domain (LBD) subtypes
    2002 Keystone Symposium on Nuclear Receptor Superfamily , Snowbird, UT (04/01/2002)

    Estrogen agonists and antagonists have differential effects on the dimer exchange kinetics and the regional dynamics behavior of the estrogen receptor: Studies using site-specific fluorescent labeled receptors
    The 83rd Annual Meeting of the Endocrine Society: ENDO 2001 , Denver, CO (06/20/2001)

    Stanford Radiology Body Rounds
    Stanford University Medical Center , Stanford, CA (09/01/2011)

    Emergency Medicine and Radiology Interdisciplinary Conference Series
    Stanford University Medical Center , Stanford, CA (10/01/2010)

    Radiology for Housestaff
    Stanford University Medical Center , Stanford, CA (09/01/2010)

    Estrogen Receptor Imaging: Sensors of underlying estrogen biology
    Medical Student Presentation, Molecular Imaging Program at Stanford, Stanford University School of Medicine , Stanford, CA (08/01/2006)

    Fluorescent estrogen receptors as molecular sensors of receptor structure and function
    25th Annual University of Illinois Medical Scholars Program Allerton Conference , Monticello, IL (08/01/2005)

    Fluorophore-labeled human estrogen receptors
    Annual University of Illinois Organic Chemistry Allerton Conference , Monticello, IL (10/07/2001)

    Pancreatic Divisum with Santorinocele
    American College of Radiology Case in Point (08/01/2013)

    Management of high hepatopulmonary shunt fractions in patients undergoing radioembolization
    Accepted: Society of Interventional Radiology , New Orleans, LA (04/01/2013)

    Bioluminescence imaging as novel approaches for studying mechanism of estrogen receptor action
    Radiologic Society of North America , Chicago, IL (11/01/2008)

    From test tubes to mice: Development of molecular estrogen sensors
    UCSF-CHE Summit on environmental challenges to reproductive health and fertility , San Francisco, CA (01/01/2007)

    Internal carotid artery dissection in primary antiphospholipid antibody syndrome: A case report
    American College of Physicians National Meeting , Philadelphia, PA (04/06/2006)

    Internal carotid artery dissection in primary antiphospholipid antibody syndrome: A case report
    American College of Physicians Illinois Chapter Meeting , Chicago, IL (11/04/2005)

    Ileocecal actinomycosis in a patient having long term corticosteroid therapy: A case report
    American College of Physicians Illinois Chapter Meeting , Chicago, IL (11/04/2005)

    Substituted naphthalene scaffolds as estrogen receptor coactivator mimics
    Abstract of Papers, 224th American Chemical Society National Meeting , Boston, MA (08/18/2002)

    Monitoring conformational changes in the human estrogen receptor alpha ligand binding domain
    The 6th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine , Kauai, HI (06/23/2002)

    The addition of chiral sulfonium salts to unfunctionalized olefins
    Abstract of Papers, 216th American Chemical Society National Meeting , Boston, MA (08/23/1998)

    The preparation and chemistry of a chiral sulfonium salt
    Abstract of Papers, 213th American Chemical Society National Meeting , San Francisco, CA (04/13/1997)

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