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Photo of Dr. Anobel Tamrazi, MD

Anobel Tamrazi, MD

Assistant Professor of Radiology in the Division of Vascular and Interventional Radiology
Assistant Professor of Radiology and Radiological Science
Male
Primary Location

The Johns Hopkins Hospital

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Titles

  • Assistant Professor of Radiology in the Division of Vascular and Interventional Radiology
  • Assistant Professor of Radiology and Radiological Science

Expertise

Diagnostic Radiology

Research Interests

As a doctoral student, Dr. Tamrazi helped develop protein based molecular sensors in evaluating the structure and function of Estrogen Receptors for in vitro drug screening of potential small molecules for the treatment of Breast Cancer. Subsequently, as a medical student and resident, he expanded on that research while working with Dr. Gambhir and the Molecular Imaging Program at Stanford to develop bioluminescence based molecular sensors for imaging of nuclear hormone receptors in living small animals. Dr. Tamrazi is focused on innovation through combining his background in basic science research and his clinical practice as an Interventional Radiologist. He is most interested in pursuing new molecular interventions as they relate to Interventional Oncology. His current research focus includes the locoregional delivery of novel molecular targeting agents (RNA, small molecules) for the treatment of hepatobiliary cancers

Biography

Dr. Anobel Tamrazi is an Assistant Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. His area of clinical expertise is diagnostic radiology.

Dr. Tamrazi earned his undergraduate degree from San Jose State University and received his M.D. and Ph.D. in chemistry from University of Illinois at Urbana-Champaign. He completed his residency at Stanford University School of Medicine and performed a fellowship in interventional radiology at Stanford University Medical Center.

Dr. Tamrazi joined the Johns Hopkins faculty in 2013.

Languages

  • English
  • Assyrian
  • Persian

Memberships

Society of Interventional Radiology Radiological Society of North America

American Chemical Society

Alpha Omega Alpha Society

Additional Resources +
  • Education +

    Training

    • University of Illinois at Champaign - Urbana ( Urbana IL ) (2007)

    Residencies

    • Stanford University School of Medicine/Radiology ( Stanford CA ) (2012)

    Fellowships

    • Stanford University Medical Center/Interventional Radiology ( Palo Alto CA ) (2013)

    Certifications

    • Diagnostic Radiology, American Board of Radiology (2012)
  • Research & Publications +

    Selected Publications

    PEER-REVIEWED PUBLICATIONS:

    1. Tamrazi A and Vasanawala S S. Functional hepatobiliary MR imaging in children. Pediatric Radiology. 41: 1250-1258 (2011).

    2. Paulmurugan R, Tamrazi A, Massoud T F, Katzenellenbogen J A, and Gambhir S S. In Vitro and In Vivo Molecular Imaging of Estrogen Receptor alpha and beta homo- and hetero-dimerization: Exploration of new modes of receptor regulation. Molecular Endocrinology. 25(12): 2029-2040 (2011).

    3. Young P M, Brau A C, Iwadate Y, Vasanawala S S, Daniel B L, Tamrazi A, and Herfkens R J. Respiratory-navigated free breathing 3D-spoiled gradient echo sequence for contrast-enhanced examination of the liver: Diagnostic utility and comparison with free breathing and breath-hold conventional exams. American Journal of Roentgenology. 195(3): 687-691 (2010).

    4. Paulmurugan R, Tamrazi A, Katzenellenbogen J A, Katzenellenbogen B S, and Gambhir S S. A human estrogen receptor (ER) alpha mutation with differential responsiveness to nonsteroidal ligands: Novel approaches for studying mechanism of ER action. Molecular Endocrinology. 22(7): 1552-1564 (2008).

    5. Benyamin R, Vallejo R, Yousuf N, Tamrazi A, and Kramer J. Incidental diagnosis of intradural lumbar disc herniation during discography: A case report. Pain Practice. 7(4): 332-336 (2007).

    6. Tamrazi A, Carlson K E, Rodrigeuz A L, and Katzenellenbogen J A. Coactivator proteins as determinants of estrogen structure and function: Spectroscopic evidence for a novel coactivator-stabilized receptor conformation. Molecular Endocrinology. 19(6): 1516-1528 (2005).

    7. Kim S H, Tamrazi A, Carlson K E, and Katzenellenbogen J A. A proteomic microarray approach for exploring ligand-initiated nuclear hormone receptor pharmacology, receptor selectivity, and hetero-dimer functionality. Molecular and Cellular Proteomics. 4(3): 267-277 (2005).

    8. Kim S H, Tamrazi A, Carlson K E, Daniels J R, Lee I Y, and Katzenellenbogen J A. Estrogen receptor microarray: Subtype-selective ligand binding. Journal of American Chemical Society. 126(15): 4754-4755 (2004).

    9. Hurth K M, Nilges M J, Carlson K E, Tamrazi A, Belford R L, and Katzenellenbogen J A. Ligand-induced changes in estrogen receptor conformations as measured by site-directed spin labeling. Biochemistry. 43(7): 1891-1907 (2004).

    10. Rodriguez A L, Tamrazi A, Collins M L, and Katzenellenbogen J A. Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding. Journal of Medicinal Chemistry. 47(3): 600-611 (2004).

    11. Tamrazi A and Katzenellenbogen J A. Site-specific fluorescent labeling of estrogen receptors and structure-activity relationships of ligands in terms of receptor dimer stability. Methods in Enzymology. 364: 37-53 (2003).

    12. Tamrazi A, Carlson K E, and Katzenellenbogen J A. Molecular sensors of estrogen receptor conformations and dynamics. Molecular Endocrinology. 17(12): 2593-2602 (2003).

    13. Tamrazi A. Fluorescent-labeled Estrogen Receptors: Molecular sensors of receptor structure and function. PhD Dissertation, University of Illinois at Urbana, 2003.

    14. Tamrazi A, Carlson K E, Daniels J R, Hurth K M, and Katzenellenbogen J A. Estrogen receptor dimerization: Ligand binding regulated dimer affinity and dimer dissociation rate. Molecular Endocrinology. 16(12): 2706-2719 (2002).

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    1. Consultant of the Year, Stanford Emergency Department; Stanford, CA; 2010 2011.

    2. Chief Resident, Stanford Radiology; Stanford, CA; 2010 2011.

    3. Alpha Omega Alpha Honor Society Award; Chicago, IL; 2007.

    4. Gold Humanism Honor Society Award; Chicago, IL; 2007.

    5. Daniel K. and Frances A. Bloomfield Fellowship in recognition of exceptional contributions to the University of Illinois Medical Scholars Program in the 2006 2007 academic year; Urbana, IL; 2007.

    6. First Place Medical Student Winner for clinical vignette poster at the American College of Physicians Illinois Chapter Meeting; Chicago, IL; Nov. 2005.

    7. Swartz-Flood Award for best student presentation at the 25th Annual University of Illinois Medical Scholars Program Allerton Conference; Monticello, IL; Aug. 2005.

    8. R.C. Fuson Memorial Travel Fund for outstanding research in organic chemistry at University of Illinois; Urbana, IL; Spring 2003.

    9. Seemon-Pines Award for the most outstanding student presentation at the Annual University of Illinois Organic Chemistry Allerton Conference; Monticello, IL; Oct. 2001.

    10. Pines Travel Award from the Organic Chemistry Department at University of Illinois to present PhD research in the form of a seminar at the institute where undergraduate degree in chemistry was obtained; Urbana, IL; Fall 2001.

    11. The Endocrine Society Travel Grant Award for exceptional research presentation at 83rd Annual Meeting of the Endocrine Society; Denver, CO; 2001.

  • Videos & Media +

    Lectures and Presentations

    NATIONAL/INTERNATIONAL PRESENTATIONS

    1. Tamrazi A and Gambhir S S. Image-Guided Tumor Targeted Delivery (IGTD). NCI Workshop; Bethesda, MD; Nov. 2010.

    2. Tamrazi A, Buu M M, and Newman B. Pictures of a Pandemic: A pediatric ICU case review series of H1N1 Influenza A. Oral presentation, European Society of Pediatric Radiology; Bordeaux, France; Jun. 2010.

    3. Tamrazi A and Katzenellenbogen J A. Fluorophore-labeled estrogen receptors: Molecular sensors of receptor conformation and conformational dynamics. 225th American Chemical Society National Meeting; New Orleans, LA; 23-27 Mar. 2003.

    4. Tamrazi A, Daniels J R, Hurth K M, and Katzenellenbogen J A. Functional fluorescent estrogen receptors (ER): Homo- and hetero-dimerization, coregulator recruitment and site-specific regional dynamics of ER-Ligand binding domain (LBD) subtypes. 2002 Keystone Symposium on Nuclear Receptor Superfamily; Snowbird, UT; Apr. 2002.

    5. Tamrazi A, Daniels J R, Hurth K M, and Katzenellenbogen J A. Estrogen agonists and antagonists have differential effects on the dimer exchange kinetics and the regional dynamics behavior of the estrogen receptor: Studies using site-specific fluorescent labeled receptors. The 83rd Annual Meeting of the Endocrine Society: ENDO 2001; Denver, CO; 20-23 Jun. 2001.

    REGIONAL PRESENTATIONS

    1. Tamrazi A. Stanford Radiology Body Rounds. Stanford University Medical Center; Stanford, CA; Sept. 2011.

    2. Tamrazi A and Grossman D. Emergency Medicine and Radiology Interdisciplinary Conference Series. Stanford University Medical Center; Stanford, CA; Oct., Nov. 2010; Apr., May, Jun., Oct. 2011; Jan., March 2012.

    3. Tamrazi A and Keel S. Radiology for Housestaff. Stanford University Medical Center; Stanford, CA; Sept. 2010.

    4. Tamrazi A and Gambhir S S. Estrogen Receptor Imaging: Sensors of underlying estrogen biology. Medical Student Presentation, Molecular Imaging Program at Stanford, Stanford University School of Medicine; Stanford, CA; Aug. 2006.

    5. Tamrazi A and Katzenellenbogen J A. Fluorescent estrogen receptors as molecular sensors of receptor structure and function. 25th Annual University of Illinois Medical Scholars Program Allerton Conference; Monticello, IL; Aug. 2005.

    6. Tamrazi A and Katzenellenbogen J A. Fluorophore-labeled human estrogen receptors. Annual University of Illinois Organic Chemistry Allerton Conference; Monticello, IL; Oct. 2001. 7. Tamrazi A, Carlson K E, and Katzenellenbogen J A. Studies using fluorescent estrogen receptors. San Jose State University; San Jose, CA; Mar. 2001.

    POSTER PRESENTATIONS

    1. Tamrazi A and Baxter R. Pancreatic Divisum with Santorinocele. American College of Radiology Case in Point. August 2013.

    2. Tamrazi A, Marnix G E H L, Louie J D, Kao, P N, Shah R P and Sze D Y. Management of high hepatopulmonary shunt fractions in patients undergoing radioembolization. Accepted: Society of Interventional Radiology; New Orleans, LA; Apr. 2013.

    3. Tamrazi A, Paulmurugan R, Katzenellenbogen J A, and Gambhir S S. Bioluminescence imaging as novel approaches for studying mechanism of estrogen receptor action. Radiologic Society of North America; Chicago, IL; Nov. 2008.

    4. Tamrazi A, Paulmurugan R, Carlson K E, Katzenellenbogen J A, and Gambhir S S. From test tubes to mice: Development of molecular estrogen sensors. UCSF-CHE Summit on environmental challenges to reproductive health and fertility; San Francisco, CA; Jan. 2007.

    5. Tamrazi A, Roychowdhury N, Thameem D, and Othman E. Internal carotid artery dissection in primary antiphospholipid antibody syndrome: A case report. American College of Physicians National Meeting; Philadelphia, PA; 6-8 Apr. 2006.

    6. Tamrazi A, Roychowdhury N, Thameem D, and Othman E. Internal carotid artery dissection in primary antiphospholipid antibody syndrome: A case report. American College of Physicians Illinois Chapter Meeting; Chicago, IL; 4 Nov. 2005.

    7. Roychowdhury N, Tamrazi A, Arwari A, and Thameem D. Ileocecal actinomycosis in a patient having long term corticosteroid therapy: A case report. American College of Physicians Illinois Chapter Meeting; Chicago, IL; 4 Nov. 2005.

    8. Rodriguez A L, Tamrazi A, and Katzenellenbogen J A. Substituted naphthalene scaffolds as estrogen receptor coactivator mimics. Abstract of Papers, 224th American Chemical Society National Meeting; Boston, MA; 18-22 Aug. 2002.

    9. Tamrazi A and Katzenellenbogen J A. Monitoring conformational changes in the human estrogen receptor alpha ligand binding domain. The 6th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine; Kauai, HI; 23-29 Jun. 2002.

    10. Jackson R, Tamrazi A, Nguyen D, and Kesler B. The addition of chiral sulfonium salts to unfunctionalized olefins. Abstract of Papers, 216th American Chemical Society National Meeting; Boston, MA; 23-27 Aug. 1998.

    11. Tamrazi A, Afshar R, and Kesler B. The preparation and chemistry of a chiral sulfonium salt. Abstract of Papers, 213th American Chemical Society National Meeting; San Francisco, CA; 13-17 Apr. 1997.

  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-6500
    Location Map
    Johns Hopkins Medicine - Green Spring Station
    10755 Falls Road
    Pavilion I
    Lutherville, MD 21093
    Phone: 410-583-2700
    Location Map
    Johns Hopkins Medicine - White Marsh
    4924 Campbell Boulevard
    White Marsh, MD 21236
    Phone: 443-442-2400
    Location Map

    Department/Division

    • Radiology and Radiological Science

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