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Thomas Schindler, M.D.

Thomas Hellmut Schindler, M.D.
Associate Professor PER at Johns Hopkins University
Associate Professor of Radiology and Radiological Science

Male  | Languages: English, French, German

Titles

  • Associate Professor PER at Johns Hopkins University
  • Director of Cardiovascular Nuclear Medicine
  • Associate Professor of Radiology and Radiological Science

Centers & Institutes

  • Johns Hopkins Hosptial Outpatient Center

Departments

Contact for Research Inquiries

Johns Hopkins University

Department of Radiology
601 N. Caroline Street
Baltimore, MD 21287 map
Phone: 410-955-8994
Fax: 443-287-2933
tschind3@jhmi.edu

Expertise

Cardiac Imaging, Cardiology , Cardiovascular Medicine, Coronary Artery Disease, Coronary Endothelial Function, Diagnostic Radiology, Internal Medicine, Nuclear Cardiology

Research Interests

cardiovascular imaging, nuclear cardiology, cardiac positron emission tomography, cardiac computed tomography, cardiac magnetic resonance imaging, coronary artery disease, coronary circulatory function, endothelial function, diabetes mellitus, obesity, myocardial viability.

Biography

Thomas Hellmut Schindler, M.D., is Director of Cardiovascular Nuclear Medicine and Associate Professor PER at Johns Hopkins Universiy, Medical School, Baltimore, MD, USA. Dr. Schindler has an international reputation in the field of Cardiovascular Imaging with focus on Nuclear Cardiology and cardiac PET/CT imaging. He received his medical degree (1995) and dissertation (doctor medecinae, 1996) from the University of Leipzig, Germany ("magna cum laude"). He is board certified for Internal Medicine, Cardiology and Nuclear Cardiology. From 2002 to 2006, Thomas Schindler completed a postdoctoral fellowship in cardiac PET imaging at the David Geffen School of Medicine at UCLA (University of California, Los Angeles, Mentor Dr. Heinrich R. Schelbert, MD, PhD). Subsequently, from 2006-2013, Thomas Schindler had joined the faculty of the University of Geneva (Switzerland), initially as assistant professor and clinical attending primarily in charge for Cardiovascular Imaging but also for General Clinical Cardiology, while being promoted academically to "Privat-Docent" in 2009 and clinically to Deputy Head Physician in Cardiology 2010 in view of his clinical services and training of residents and fellows. He has authored over 71 peer review publications with an impact factor exceeding 287 mainly as first and senior author, and numerous book chapters. He has been member of the board of directors (BOD) of the cardiovascular committees (CVC) of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), Cardiovascular Section (CC) of the European Society of Nuclear Medicine (EANM), and the European Society of Cardiology (ESC) for several years and he is involved in numerous conferences as organizer and invited speaker. Thomas Schindler established Nuclear Cardiology and cardiac PET centers at the Universities of Freiburg (Germany), Basel and Geneva (Switzerland). while performing major contributions in the identification and characterization of coronary circulatory dysfunction, as functional precursor of CAD, by means of PET flow studies during his postdoctoral fellowship at UCLA and subsequently in Geneva (Switzerland). This research provides a frame work for designing treatments strategies for modifying and/or reducing coronary risk. His overall vision is to develop cardiac SPECT- and PET-CT and other cardiac imaging modalities in the clinical routine for the assessment of early and late stages of CAD with its diagnostic and prognostic implications, while pursuing the advancement of molecular imaging in cardiac disease.

 

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    Additional Information

  • Education +

    Degrees

    • Universitaet Leipzig / M.D. (1995)

    Residencies

    • Albert Ludwigs Universitate Freiburg (1999)
    • Institute of Internal Medicine and Radiology / Internal Medicine (2000)

    Fellowships

    • University of Basel Medical School / Cardiology (2002)
    • Ronald Reagan UCLA Medical Center (2006)
    • Ronald Reagan UCLA Medical Center / Pulmonary and Critical Care Medicine (2006)
  • Research & Publications +

    Selected Publications

    1. Schindler TH, Lima JAC. Assessment of myocardial matrix expansion with cardiac magnetic resonance: entering a new area of cardiac risk stratification in type 2 diabetes mellitus? Eur Heart J 2014; 36(10):608-11.
    2. Quercioli A, Montecucco F, Pataky Z, Harsch E, Thomas A, Ambrosio G, Staub C, Di Marzo V, Ratib O, Mach F, Golay A, Schindler, TH. Improvement of Coronary Circulatory Function in Morbidly Obese Individuals after Gastric Bypass induced Weight Loss - Relation to Alterations in Endocannabinoids and Adipocytokines - Eur Heart J 2013; 34(27):2063-73.

    3. Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, Camici PG, Cerqueira MD, Chow JW,Di Carli MF, Dorbala S, Gewirtz H, Gropler RJ, Kaufmann PA, Knuuti J, Merhige ME,Rentrop KP, Ruddy TD, Schelbert HR, Schindler TH, Schwaiger M, Sdringola S, Vitarello J, Williams KA, Dilsizian V, Narula J. Anatomic versus physiologic assessment of coronary artery disease: role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making.J Am Coll Cardiol 2013;62(18):1639-53. (Review)

    4. Schindler TH, Dilsizian V. Cardiac PET-CT Imaging of the Renin-Angiotensin System in Humans Holds Promise for Image-Guided Approach to Heart Failure Therapy. J Am Coll Cardiol 2012; 18;60(24):2535-8 (editorial comment)

    5. Quercioli A., Pataky Z, Montecucco F., Carballo S, Thomas A, Staub C, Di Marzo V, Vincenti G, Ambrosio G, Ratib O, Golay A, Mach F, Harsch E, Schindler TH. Coronary Vasomotor Control in Obesity and Morbid Obesity: Contrasting Flow Responses with Endocannabinoids, Leptin, and Inflammation. J Am Coll Cardiol Img 2012;5:805-815.

    6. Quercioli A, Pataky Z, Vincenti G, Makoundou V, Di Marzo V, Montecucco F, Carballo S, Thomas A, Staub C, Steffens S, Seimbille Y, Golay A, Ratib O, Harsch E, Mach, F, Schindler TH. Elevated Endocannabinoid Plasma Levels are Associated with Coronary Circulatory Dysfunction in Obesity. Eur Heart J 2011; Jun;32(11):1369-78.

    7. Schindler TH, Schelbert HR, Quercioli A, Dilsizian V. Emerging Role of PET Imaging for the Identification and Monitoring of Coronary Artery Disease and Microvascular Health. J Am Coll Cardiol Img 2010; 3:623– 40.

    8. Schindler TH, Cadenas J, Facta AD, Li Y, Olschewski M, Sayre J, Goldin J, Schelbert HR. Improvement in Coronary Endothelial Function is Independently Associated with a Slowed Progression of Coronary Artery Calcification in Type 2 Diabetes Mellitus. Eur Heart J 2009 Dec;30(24):3064-73.

    9. Schindler TH, Campisi R, Dorsey D, Prior JO, Facta AD, Zhang XL, Sayre J, Schelbert HR. Beneficial Long-Term Effect of Hormone Replacement Therapy on Coronary Vasomotor Function in Postmenopausal Women with Medically-Treated Coronary Risk Factors. Eur Heart J 2009; 30(8):978-86.

    10. Schindler TH,Cadenas J, Facta AD, Prior JO, Kreissl M, Zhang XL, Sayre J, Dahlbom M, Julio Licinio, Schelbert HR.Relationship between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function. J Am Coll Cardiol 2006;47:1188-1195.

    11. Schindler TH, Nitzsche EU, Schelbert HR, Olschewski M, Sayre, Mix M, BrinkI, Zhang X-L, Kreissl M, Magosaki M, Just H, Solzbach U. PET-Measured Abnormal Responses of Myocardial Blood Flow to Sympathetic Stimulation are Associated with the Risk of Developing Cardiovascular Events. J Am Coll Cardiol 2005; 45 (9): 1505-1512.

    12. Schindler TH , Nitzsche EU, Olschewski M, Magosaki N, Mix M, Prior JO,Facta AD, Solzbach U, Just H, Schelbert HR. Chronic Inflammation and Abnormal Coronary Vasomotion. Circulation 2004; 110:1069-1075.

    13. Schindler TH, Nitzsche EU, Muenzel T, Brink I, Jeserich M, Olschewski M, Buser PT, Matthias Pfisterer M, Solzbach U, Just H. Coronary Vasoregulation in Patients with Various Risk Factors in Response to Cold Pressor Testing: - Contrasting Myocardial Blood Flow Responses to Short- and Long-Term Vitamin C Administration - J Am Coll Cardiol 2003;42(5):814-822

    14. Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Nitzsche E, Pfisterer M, Solzbach U, Just H. Prognostic Value of Abnormal Vasoreactivity of Epicardial Coronary Arteries to Sympathetic Stimulation in Patients with Normal Coronary Angiograms. Arterioscler Thromb Vasc Biol 2003; 23:495-501.

    15. Schindler TH, Nitzsche EU, M Olschewski, I Brink, M Mix, JO Prior, A Facta, M Inubushi, H Just, HR Schelbert. PET-measured Responses in Myocardial Blood Flow to Cold Pressor Testing Correlate with Indices of Coronary Vasomotion on Quantitative Angiography. J Nucl Med 2004;45: 419-428.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Cardiovascular Young Investigator Imaging Award,  Society of Nuclear Medicine
    • Cardiovascular Young Investigator Imaging Award,  Society of Nuclear Medicine
    • Clinical Research Award, American Society of Nuclear Cardiology (ASNC) , 2006
    • Elite Reviewer Award of the Year 2011, Journals of the American College of Cardiology (JACC), 2011
    • Elite Reviewer Award of the Year 2012, Journals of the American College of Cardiology (JACC), 2012

    Memberships

    • American College of Cardiology (ACC)
    • American Heart Association (AHA):
                a) Council of Cardiovascular Radiology           b) Council of Arteriosclerosis, Thrombosis, and Vascular Biology
    • American Society of Nuclear Cardiology (ASNC)
    • European Society of Cardiology (ESC)
    • European Society of Nuclear Medicine (EANM)
    • German Society of Cardiology
    • International Society for Cardiovascular Translational Research (ISCTR)
    • Society of Cardiovascular Computed Tomography (SCCT)
    • Swiss Society of Cardiology
    • The American Physiology Society
    • The Society of Nuclear Medicine and Molecular Imaging (SNMMI)

    Professional Activities

    • Board of Directors, Society of Nuclear Medicine, 2007 - 2012
      Cardiovascular Council
    • Working Group, Coronary Pathophysiology and Microcirculation of the ESC , 2009
    • Section Editor, Current Cardiovascular Imaging Reports , 2010
    • Co-editor-in-Chief, Current Cardiovascular Imaging Reports , 2011
    • Committee for Practice Guidelines, European Society of Cardiology, 2012
      For the Diagnosis and Management of Acute Pulmonary Embolism 
    • Vice-President Elect of the Board of Directors, Cardiovascular Council of  the Society of Nuclear Medicine and Molecular Imaging, 2013 - 2014
  • Videos & Media +

    Lectures and Presentations

    Role of PET/CT and CT - Coronary Angiography in the Identification and Characterization of CAD
    Essen, Germany (09/26/2013)
    Universitätsklinikum Essen - Westdeutsches Herzzentrum

     Obesity, Endocannabinoids, and Coronary Circulatory Dysfunction as Functional Precursor of CAD
    Baltimore, Maryland (05/22/2013)
    Johns Hopkins Medical School - Department of Endocrinology and Metabolism

    Possibilities of PET/CT and CT in the Identification and Characterization of CAD
    Heidelberg, Germany (04/11/2013)
    University Hospital of Heidelberg - Department of Internal Medicine and Cardiology

    Myocardial perfusion imaging with SPECT, PET and hybrid imaging
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Copenhagen, Denmark (09/17/2012)
    University of Copenhagen

    Myocardial metabolism by radionuclide imaging techniques
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Copenhagen, Denmark (09/18/2012)
    University of Copenhagen

     The future challenge of Nuclear Cardiology
    13th National Symposium of the Chinese Society of Nuclear Cardiology , Taiyuan, China (07/06/2012)

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Cardiology , Bronx, New York (01/09/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Nuclear Medicine , Bronx, New York (01/10/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    Contributions of PET/CT in Assessing Coronary Physiology and Abnormalities as Functional Precursor of the CAD Process
    Ottawa, Canada (09/14/2011)
    University of Ottawa - National Heart Institute

    Role of PET/CT in the Identification and Characterization of the CAD Process
    11th National Symposium of the Chinese Society of Nuclear Cardiology , Ychang, China (06/22/2010)

    Role of PET/CT in the Identification and Characterization of subclinical and clinically manifest CAD
     Grand Rounds Lectures , Essen, Germany (04/12/2010)
    University Hospital of Essen - West-German Heart Centre

    Role of PET/CT and CT - Coronary Angiography in the Identification and Characterization of CAD
    Essen (01/26/2013)
    Universitätsklinikum Essen

     Obesity Endocannabinoids and Coronary Circulatory Dysfunction as Functional Precursor of CAD
    Baltimore (01/22/2013)
    Johns-Hopkins Medical School

    Possibilities of PET/CT and CT in the Identification and Characterization of CAD
    Germany (01/11/2013)
    University Hospital of Heidelberg

    Myocardial perfusion imaging with SPECT PET and hybrid imaging
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Denmark (01/17/2012)
    University of Copenhagen

    Myocardial metabolism by radionuclide imaging techniques
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Denmark (01/18/2012)
    University of Copenhagen

     The future challenge of Nuclear Cardiology
    13th National Symposium of the Chinese Society of Nuclear Cardiology , Shanxi (01/06/2012)
     Taiyuan

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Cardiology , Bronx (01/09/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Nuclear Medicine , Bronx (01/10/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    Contributions of PET/CT in Assessing Coronary Physiology and Abnormalities as Functional Precursor of the CAD Process
    Ottawa (01/14/2011)
    University of Ottawa

    Role of PET/CT in the Identification and Characterization of the CAD Process
    11thNational Symposium of the Chinese Society of Nuclear Cardiology , China (01/22/2010)
    Ychang

    Role of PET/CT in the Identification and Characterization of subclinical and clinically manifest CAD
     Grand Rounds Lectures , West-German Heart Centre (01/12/2010)
    University Hospital of Essen

    Assessment of Myocardial Viability: Multimodality Interpretation and Comparison
    Annual Meeting of the European Society of Nuclear Medicine , Lyon, France (10/21/2013)

    Role of PET/CT and CT - Coronary Angiography in the Identification and Characterization of CAD
    Essen, Germany (09/26/2013)
     University Hospital of Essen - Westgerman Heart Centre

    Assessment of Cardiac Sarcoidosis
    European Society of Cardiology (ESC, annual meeting) , Amsterdam, Netherland (09/01/2013)

    Role of Imaging Myocardial Viability with PET/CT in Patients with Advanced Heart Failure
    Baltimore, Maryland (07/29/2013)
    Johns Hopkins Medical School - Department of Radiology - Division of Nuclear Medicine

    Obesity, Endocannabinoids, and Coronary Circulatory Dysfunction as Functional Precursor of CAD
    Baltimore, Maryland (05/22/2013)
    Johns-Hopkins Medical School - Department of Endocrinology and Metabolism

    Possibilities of PET/CT and CT in the Identification and Characterization of CAD
    Heidelberg, Germany (04/11/2013)
    University Hospital of Heidelberg - Department of Internal Medicine and Cardiology

    Assessing Coronary Pathophysiology with PET/CT
    Nuclear Medicine, Maryland (01/22/2013)
    John Hopkins University in Baltimore - Department of Radiology

    Quantitative PET/CT Measures of Coronary Flow Reserve with Existing and Novel Tracers
    Society of Nuclear Medicine’s Annual Midwinter-Meeting , New Orleans, Louisiana (01/26/2013)

    Importance of Microvascular Dysfunction in Cardiovascular Disease
    ICNC (International Conference of Non-Invasive Cardiovascular Imaging) , Berlin, Germany (05/08/2013)

    Computed tomography, MRI, and Echocardiography for the Assessment of viable Myocardium
    ICNC (International Conference of Non-Invasive Cardiovascular Imaging) , Berlin, Germany (05/06/2013)

    How to Image Special Populations – Case based Session
    ICNC (International Conference of Non-Invasive Cardiovascular Imaging) , Berlin, Germany (05/06/2013)

    MRI and Echocardiography to assess Myocardial Viability
    SNMMI 60th Annual Scientific Session , Vancouver, BC (06/08/2013)

    Role of Imaging Myocardial Viability and Innervations in Patients with Advanced Heart Failure
    SNMMI 60th Annual Scientific Session , Vancouver, BC (06/08/2013)

    Assessment of myocardial perfusion and viability with PET/CT
    SNMMI 60th Annual Scientific Session , Vancouver, BC (06/08/2013)

    Optimal Therapy for Coronary Artery Disease and Radionuclide Imaging to Guide Patient Management
    SNMMI 60th Annual Scientific Session , Vancouver, BC (06/08/2013)

    Myocardial perfusion imaging with SPECT, PET and hybrid imaging
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Copenhagen, Denmark (09/17/2012)
    University of Copenhagen

    Myocardial metabolism by radionuclide imaging techniques
    PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences , Copenhagen, Denmark (09/18/2012)
    University of Copenhagen

    Contributions of PET/CT to characterize coronary morphology and myocardial perfusion
    Baltimore, Marylanbd (09/08/2012)
    John Hopkins University in Baltimore - Department of Nuclear Medicine

    PET myocardial flow reserve assessment of multi-vessel disease
    Annual ESC Meeting , Munich, Germany (08/26/2012)

    Will PET replace single-photon emission computed tomography?
    Annual ESC Meeting , Munich, Germany (08/26/2012)

    The future challenge of Nuclear Cardiology
    13th National Symposium of the Chinese Society of Nuclear Cardiology , Taiyuan, Shanxi (07/06/2012)

    Imaging for Prevention and Treatment Response in Atherosclerosis
    Society of Nuclear Medicine’s 59nd Annual Meeting , Miami, Florida (06/12/2012)

    Cardiac PET: Role of Quantitative Analysis of Myocardial Perfusion
    Society of Nuclear Medicine’s 59nd Annual Meeting , Miami, Florida (06/12/2012)

    Cardiac PET Imaging for the Detection and Monitoring of Coronary Artery Disease and Microvascular Health
    Frontiers in CardioVascular Biology , London, Great Britain (03/31/2012)
    Imperial College in London

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Cardiology , Bronx, New York (01/09/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process
    Grand Rounds Lectures in Nuclear Medicine , Bronx, New York (01/10/2012)
    The Montefiore University Hospital for Albert Einstein College of Medicine

    The Unusual Imaging Case (ALPACA)
    European Heart Imaging Meeting , Basel, Switzerland (10/21/2011)

    Contributions of PET/CT in Assessing Coronary Physiology and Abnormalities as Functional Precursor of the CAD Process
    Ottawa, Canada (09/14/2011)
    University of Ottawa - National Heart Institute

    18F-FDG PET/CT imaging in cardiovascular disease: Myocardial Viability Imaging with PET/CT: Comparison to CMR
    Society of Nuclear Medicine’s 58nd Annual Meeting , San Antonio, Texas (06/06/2011)

    Strong and weak points of nuclear cardiology, cardiac MRI, and CT-Coronary angiography in identifying CAD
    1rst Molecular and Clinical Cardiovascular Imaging Symposium , Geneva, Switzerland (04/15/2011)

    Contributions of cardiac PET/CT imaging in the evaluation and understanding of coronary pathophysiology
    1rst Molecular and Clinical Cardiovascular Imaging Symposium , Geneva, Switzerland (04/15/2011)

    Myocardial Perfusion Imaging- State of the Art: Positron Emission Tomography
    Annual meeting of the European Society of Cardiology (ESC) , Stockholm, Sweden (08/30/2010)

    Role of PET/CT in the Identification and Characterization of the CAD Process
    11th National Symposium of the Chinese Society of Nuclear Cardiology , Ychang, China (06/22/2010)

    Multimodality Imaging of Myocardial Viability: Strengths and weaknesses of Myocardial Viability Imaging with PET and CMR
    Society of Nuclear Medicine’s 57nd Annual Meeting , Salt Lake City, Utah (06/06/2010)

    Cardiovascular Basic PET Quantification and Modelling
    Society of Nuclear Medicine’s 57nd Annual Meeting , Salt Lake City, Utah (06/08/2010)

    Role of PET/CT in the Identification and Characterization of subclinical and clinically manifest CAD
    Essen, Germany (04/12/2010)
    University Hospital of Essen - West-German Heart Centre

    Non-Invasive Quantification of Cardiac Blood Flow: Prognosis of Absolute Myocardial Blood Flow Assessment
    59th annual meeting of the American College of Cardiology (ACC) , Atlanta, Georgia (03/15/2010)

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