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Thomas Schindler, MD

Thomas Hellmut Schindler, MD
Associate Professor PER at Johns Hopkins University
Associate Professor of Radiology and Radiological Science
Male

Titles

  • Associate Professor PER at Johns Hopkins University
  • Director of Cardiovascular Nuclear Medicine
  • Associate Professor of Radiology and Radiological Science

Centers & Institutes

  • Johns Hopkins Hosptial Outpatient Center

Expertise

Cardiac Imaging, Cardiology, Cardiovascular Medicine, Coronary Artery Disease, Coronary Endothelial Function, Diagnostic Radiology, Internal Medicine, Nuclear Cardiology

Research Interests

cardiovascular imaging, nuclear cardiology, cardiac positron emission tomography, cardiac computed tomography, cardiac magnetic resonance imaging, coronary artery disease, coronary circulatory function, endothelial function, diabetes mellitus, obesity, myocardial viability.

Biography

Thomas Hellmut Schindler, M.D., is Director of Cardiovascular Nuclear Medicine and Associate Professor PER at Johns Hopkins Universiy, Medical School, Baltimore, MD, USA. Dr. Schindler has an international reputation in the field of Cardiovascular Imaging with focus on Nuclear Cardiology and cardiac PET/CT imaging. He received his medical degree (1995) and dissertation (doctor medecinae, 1996) from the University of Leipzig, Germany ("magna cum laude"). He is board certified for Internal Medicine, Cardiology and Nuclear Cardiology. From 2002 to 2006, Thomas Schindler completed a postdoctoral fellowship in cardiac PET imaging at the David Geffen School of Medicine at UCLA (University of California, Los Angeles, Mentor Dr. Heinrich R. Schelbert, MD, PhD). Subsequently, from 2006-2013, Thomas Schindler had joined the faculty of the University of Geneva (Switzerland), initially as assistant professor and clinical attending primarily in charge for Cardiovascular Imaging but also for General Clinical Cardiology, while being promoted academically to "Privat-Docent" in 2009 and clinically to Deputy Head Physician in Cardiology 2010 in view of his clinical services and training of residents and fellows. He has authored over 71 peer review publications with an impact factor exceeding 287 mainly as first and senior author, and numerous book chapters. He has been member of the board of directors (BOD) of the cardiovascular committees (CVC) of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), Cardiovascular Section (CC) of the European Society of Nuclear Medicine (EANM), and the European Society of Cardiology (ESC) for several years and he is involved in numerous conferences as organizer and invited speaker. Thomas Schindler established Nuclear Cardiology and cardiac PET centers at the Universities of Freiburg (Germany), Basel and Geneva (Switzerland). while performing major contributions in the identification and characterization of coronary circulatory dysfunction, as functional precursor of CAD, by means of PET flow studies during his postdoctoral fellowship at UCLA and subsequently in Geneva (Switzerland). This research provides a frame work for designing treatments strategies for modifying and/or reducing coronary risk. His overall vision is to develop cardiac SPECT- and PET-CT and other cardiac imaging modalities in the clinical routine for the assessment of early and late stages of CAD with its diagnostic and prognostic implications, while pursuing the advancement of molecular imaging in cardiac disease.

 

Languages

  • English
  • German
  • French

Memberships

- American Heart Association (AHA):

          a) Council of Cardiovascular Radiology

          b) Council of Arteriosclerosis, Thrombosis, and Vascular Biology

- American College of Cardiology (ACC)

- European Society of Cardiology (ESC)

- The Society of Nuclear Medicine and Molecular Imaging (SNMMI)

- European Society of Nuclear Medicine (EANM)

- American Society of Nuclear Cardiology (ASNC)

- The American Physiology Society

- Society of Cardiovascular Computed Tomography (SCCT)

- International Society for Cardiovascular Translational Research (ISCTR)

- German Society of Cardiology

- Swiss Society of Cardiology

Additional Resources +
  • Education +

    Training

    • Universitaet Leipzig (Leipzig ) (1995)

    Residencies

    • Institute of Internal Medicine and Radiology / Internal Medicine (Achern ) (2000)
    • Albert Ludwigs Universitate Freiburg (Freiburg Im Breisgau ) (1999)

    Fellowships

    • UCLA Medical Center (Los Angeles CA) (2006)
    • UCLA Medical Center / Pulmonary and Critical Care Medicine (Los Angeles CA) (2006)
    • University of Basel Medical School / Cardiology (Basel ) (2002)
  • Research & Publications +

    Selected Publications

    1. Schindler TH, Lima JAC. Assessment of myocardial matrix expansion with cardiac magnetic resonance: entering a new area of cardiac risk stratification in type 2 diabetes mellitus? Eur Heart J 2014; 36(10):608-11.
    2. Quercioli A, Montecucco F, Pataky Z, Harsch E, Thomas A, Ambrosio G, Staub C, Di Marzo V, Ratib O, Mach F, Golay A, Schindler, TH. Improvement of Coronary Circulatory Function in Morbidly Obese Individuals after Gastric Bypass induced Weight Loss - Relation to Alterations in Endocannabinoids and Adipocytokines - Eur Heart J 2013; 34(27):2063-73.

    3. Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, Camici PG, Cerqueira MD, Chow JW,Di Carli MF, Dorbala S, Gewirtz H, Gropler RJ, Kaufmann PA, Knuuti J, Merhige ME,Rentrop KP, Ruddy TD, Schelbert HR, Schindler TH, Schwaiger M, Sdringola S, Vitarello J, Williams KA, Dilsizian V, Narula J. Anatomic versus physiologic assessment of coronary artery disease: role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making.J Am Coll Cardiol 2013;62(18):1639-53. (Review)

    4. Schindler TH, Dilsizian V. Cardiac PET-CT Imaging of the Renin-Angiotensin System in Humans Holds Promise for Image-Guided Approach to Heart Failure Therapy. J Am Coll Cardiol 2012; 18;60(24):2535-8 (editorial comment)

    5. Quercioli A., Pataky Z, Montecucco F., Carballo S, Thomas A, Staub C, Di Marzo V, Vincenti G, Ambrosio G, Ratib O, Golay A, Mach F, Harsch E, Schindler TH. Coronary Vasomotor Control in Obesity and Morbid Obesity: Contrasting Flow Responses with Endocannabinoids, Leptin, and Inflammation. J Am Coll Cardiol Img 2012;5:805-815.

    6. Quercioli A, Pataky Z, Vincenti G, Makoundou V, Di Marzo V, Montecucco F, Carballo S, Thomas A, Staub C, Steffens S, Seimbille Y, Golay A, Ratib O, Harsch   E, Mach, F, Schindler TH. Elevated Endocannabinoid Plasma Levels are Associated with Coronary Circulatory Dysfunction in Obesity. Eur Heart J 2011; Jun;32(11):1369-78.

    7. Schindler TH, Schelbert HR, Quercioli A, Dilsizian V. Emerging Role of PET Imaging for the Identification and Monitoring of Coronary Artery Disease and Microvascular Health. J Am Coll Cardiol Img 2010; 3:623– 40.

    8. Schindler TH, Cadenas J, Facta AD, Li Y, Olschewski M, Sayre J, Goldin J, Schelbert HR.  Improvement in Coronary Endothelial Function is Independently Associated with a Slowed Progression of Coronary Artery Calcification in Type 2 Diabetes Mellitus. Eur Heart J 2009 Dec;30(24):3064-73. 

    9. Schindler TH, Campisi R, Dorsey D, Prior JO, Facta AD, Zhang XL, Sayre J, Schelbert HR. Beneficial Long-Term Effect of Hormone Replacement Therapy on Coronary Vasomotor Function in Postmenopausal Women with Medically-Treated Coronary Risk Factors. Eur Heart J 2009; 30(8):978-86.

    10. Schindler TH,Cadenas J, Facta AD, Prior JO, Kreissl M, Zhang XL, Sayre J, Dahlbom M, Julio Licinio, Schelbert HR.Relationship between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function. J Am Coll Cardiol 2006;47:1188-1195.

    11. Schindler TH, Nitzsche EU, Schelbert HR, Olschewski M, Sayre, Mix M, BrinkI, Zhang X-L, Kreissl M, Magosaki M, Just H, Solzbach U. PET-Measured Abnormal Responses of Myocardial Blood Flow to Sympathetic Stimulation are Associated with the Risk of Developing Cardiovascular Events. J Am Coll Cardiol 2005; 45 (9): 1505-1512.

    12. Schindler TH , Nitzsche EU, Olschewski M, Magosaki N, Mix M, Prior JO,Facta AD, Solzbach U, Just H, Schelbert HR. Chronic Inflammation and Abnormal Coronary Vasomotion. Circulation 2004; 110:1069-1075.

    13. Schindler TH, Nitzsche EU, Muenzel T, Brink I, Jeserich M, Olschewski M,  Buser PT, Matthias Pfisterer M, Solzbach U, Just H. Coronary Vasoregulation in Patients with Various Risk Factors in Response to Cold Pressor Testing: - Contrasting Myocardial Blood Flow Responses to Short- and Long-Term Vitamin C Administration - J Am Coll Cardiol 2003;42(5):814-822

    14. Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Nitzsche E,  Pfisterer M, Solzbach U, Just H. Prognostic Value of Abnormal Vasoreactivity of Epicardial Coronary Arteries to Sympathetic Stimulation in Patients with Normal Coronary Angiograms.  Arterioscler Thromb Vasc Biol 2003; 23:495-501.

    15. Schindler TH, Nitzsche EU, M Olschewski, I Brink, M Mix, JO Prior, A Facta, M Inubushi, H Just, HR Schelbert. PET-measured Responses in Myocardial Blood Flow to Cold Pressor Testing Correlate with Indices of Coronary Vasomotion on Quantitative Angiography. J Nucl Med 2004;45: 419-428.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Young Investigator Awards:

    1)      Cardiovascular Young Investigator Imaging Award 2004: Society of Nuclear Medicine 51th Annual Meeting, Philadelphia (Pennsylvania): “Abnormal longitudinal, base-to-apex myocardial perfusion gradient in response to cold-pressor-test as assessed by PET correlates with indices of epicardial vasomotion on quantitative angiography.”

    2)      Cardiovascular Young Investigator Imaging Award 2005: Society of Nuclear Medicine 52th Annual Meeting, Toronto (Canada): “Angiotensin receptor blockade in patients with impaired glucose tolerance reverses abnormal endothelium-dependent coronary vasomotion as monitored with PET”.

     3)   American Society of Nuclear Cardiology (ASNC) Clinical Research Award 2006: “Relationship between Obesity, Inflammation, Adipocytokines and PET-determined Coronary Circulatory Function and its Alterations by Weight Loss due to Laparoscopic Adjustable Gastric Banding”.

     Reviewer Awards:

     1)   Elite Reviewer Award of the Year 2011 for the Journals of the American College of Cardiology (JACC), American College of Cardiology (ACC), 61th Annual Meeting, Chicago (USA), 25th of March 2012.  

     2)   Elite Reviewer Award of the Year 2012 for the Journals of the American College of Cardiology (JACC), American College of Cardiology (ACC), 62th Annual Meeting, San Francisco (USA), 10th of March 2012.  

    Professional Activities

    Leadership (Official Functions)

    ○ Vice-President Elect of the Board of Directors (BOD) of the Cardiovascular Council of  the Society of Nuclear Medicine and Molecular Imaging (SNMMI) (2013-2014)

    ○ International Editorial Board Member of the European Heart Journal (EHJ) (since  2011).

    ○ Co-editor-in-Chief of Current Cardiovascular Imaging Reports (since 2011)

    ○ Section Editor (Technical Advances in Cardiac Multi-Modality Imaging) of Current Cardiovascular Imaging Reports (since 2010).

    ○ International Editorial Board Member of the Journal of Nuclear Cardiology (JNC) (since 2012)

    ○ European Society of Cardiology (ESC) Committee for Practice Guidelines (CPG) for the Diagnosis and Management of Acute Pulmonary Embolism (since 2012).

    ○ Nucleus Member, Secretary (2009) and web-editor (since 2010) of the Working Group of Nuclear Cardiology and CT of the European Society of Cardiology (ESC) (2009-2014).

    ○ Board of Directors (BOD) of the Cardiovascular Council (CVC) of the Society of Nuclear Medicine (SNM) (2007-2012).

    Ex Officio Member of the Cardiovascular Council (CVC) of the Society of Nuclear Medicine (SNM) (2012-2013)

    ○ Member of the Cardiovascular Council (CVC) Committee of the European Society of Nuclear Medicine (EANM) (since 2012).

    ○ Member of the European Council of Nuclear Cardiology (ECNC) (since 2013)

    ○ Working Group of Coronary Pathophysiology and Microcirculation of the ESC (since 2009).

    ○ Member of the ACC – Geriatric Cardiology Section (since 2011).

  • Videos & Media +

    Lectures and Presentations

    2010-2013

    1. Assessment of Myocardial Viability: Multimodality Interpretation and Comparison. 21 October 2013, Annual Meeting of the European Society of Nuclear Medicine, Lyon, France.
    2. Role of PET/CT and CT - Coronary Angiography in the Identification and Characterization of CAD. 26 September 2013, University Hospital of Essen, Westgerman Heart Centre,  Essen, Germany.
    3. Assessment of Cardiac Sarcoidosis. 1 September 2013, European Society of Cardiology (ESC, annual meeting), Amsterdam, Netherland.
    4. Role of Imaging Myocardial Viability with PET/CT in Patients with Advanced Heart Failure. 29 July 2013, Johns Hopkins Medical School, Department of Radiology, Div. of Nuclear Medicine, Baltimore, Maryland, USA.
    5. Obesity, Endocannabinoids, and Coronary Circulatory Dysfunction as Functional Precursor of CAD. 22 May 2013, Johns-Hopkins Medical School, Department of Endocrinology and Metabolism, Baltimore, Maryland, USA.
    6. Possibilities of PET/CT and CT in the Identification and Characterization of CAD. 11 April 2013, University Hospital of Heidelberg, Department of Internal Medicine and Cardiology, Germany.  
    7. Assessing Coronary Pathophysiology with PET/CT. 22th January 2013, John Hopkins University in Baltimore, Department of Radiology, Nuclear Medicine, Maryland, USA.
    8. Quantitative PET/CT Measures of Coronary Flow Reserve with Existing and Novel Tracers. 26 January 2013, Society of Nuclear Medicine’s Annual Midwinter-Meeting, New Orleans, Louisiana, USA.
    9. Importance of Microvascular Dysfunction in Cardiovascular Disease. 8th May 2013, ICNC (International Conference of Non-Invasive Cardiovascular Imaging), Berlin, Germany.
    10. Computed tomography, MRI, and Echocardiography for the Assessment of viable Myocardium. 6th May 2013, ICNC (International Conference of Non-Invasive Cardiovascular Imaging), Berlin, Germany.
    11. How to Image Special Populations – Case based Session. 6th May 2013, ICNC (International Conference of Non-Invasive Cardiovascular Imaging), Berlin, Germany.  
    12. MRI and Echocardiography to assess Myocardial Viability. 8-12th June 2013, SNMMI 60th Annual Scientific Session; Vancouver, BC, Canada.
    13. Role of Imaging Myocardial Viability and Innervations in Patients with Advanced Heart Failure. 8-12th June 2013, SNMMI 60th Annual Scientific Session; Vancouver, BC, Canada.
    14. Assessment of myocardial perfusion and viability with PET/CT. 8-12th June 2013, SNMMI 60th Annual Scientific Session; Vancouver, BC, Canada.
    15. Optimal Therapy for Coronary Artery Disease and Radionuclide Imaging to Guide Patient Management. 8-12th June 2013, SNMMI 60th Annual Scientific Session; Vancouver, BC, Canada.
    16. Myocardial perfusion imaging with SPECT, PET and hybrid imaging. 17 September 2012, PhD-course:    Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences, University of Copenhagen, Denmark.
    17. Myocardial metabolism by radionuclide imaging techniques. 18 September 2012, PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences, University of Copenhagen, Denmark.
    18. Contributions of PET/CT to characterize coronary morphology and myocardial perfusion. 8th September 2012, John Hopkins University in Baltimore, Department of Nuclear Medicine, Maryland, USA.
    19. PET myocardial flow reserve assessment of multi-vessel disease. 26th August 2012, Annual ESC Meeting, Munich, Germany.
    20. Will PET replace single-photon emission computed tomography? 26th August 2012, Annual ESC Meeting, Munich, Germany.
    21. The future challenge of Nuclear Cardiology. 6 July 2012, 13th National Symposium of the Chinese Society of Nuclear Cardiology. Taiyuan, Shanxi, China.
    22. Imaging for Prevention and Treatment Response in Atherosclerosis. 12 June 2012, Society of Nuclear Medicine’s 59nd Annual Meeting, Miami, Florida, USA. 
    23. Cardiac PET: Role of Quantitative Analysis of Myocardial Perfusion. 12 June 2012, Society of Nuclear Medicine’s 59nd Annual Meeting, Miami, Florida, USA. 
    24. Cardiac PET Imaging for the Detection and Monitoring of Coronary Artery Disease and Microvascular Health. 31th March 2012, Frontiers in CardioVascular Biology, Imperial College in London, London, Great Britain. 
    25. Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process. 9th January 2012, Grand Rounds Lectures in Cardiology, The Montefiore University Hospital for Albert Einstein College of Medicine, Bronx, New York, USA.
    26. Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process. 10th January 2012, Grand Rounds Lectures in Nuclear Medicine, The Montefiore University Hospital for Albert Einstein College of Medicine, Bronx, New York, USA.
    27. The Unusual Imaging Case (ALPACA). 21 october 2011, European Heart Imaging Meeting, Basel, Switzerland.
    28. Contributions of PET/CT in Assessing Coronary Physiology and Abnormalities as Functional Precursor of the CAD Process.14 september 2011, University of Ottawa, National Heart Institute, Ottawa, Canada.    
    29. 18F-FDG PET/CT imaging in cardiovascular disease: Myocardial Viability Imaging with PET/CT: Comparison to CMR. 6 June 2011, Society of Nuclear Medicine’s 58nd Annual Meeting, San Antonio, Texas, USA. 
    30. Strong and weak points of nuclear cardiology, cardiac MRI, and CT-Coronary angiography in identifying CAD.  15.04.2011; 1rst Molecular and Clinical Cardiovascular Imaging Symposium Geneva, Switzerland. 
    31. Contributions of cardiac PET/CT imaging in the evaluation and understanding of coronary pathophysiology.  15.04.2011; 1rst Molecular and Clinical Cardiovascular Imaging Symposium Geneva, Switzerland. 
    32. Myocardial Perfusion Imaging- State of the Art: Positron Emission Tomography. 30 august 2010, Annual meeting of the European Society of Cardiology (ESC), Stockholm, Sweden.
    33. Role of PET/CT in the Identification and Characterization of the CAD Process. 22 june 2010, 11th National Symposium of the Chinese Society of Nuclear Cardiology. Ychang, China.
    34. Multimodality Imaging of Myocardial Viability: Strengths and weaknesses of Myocardial Viability Imaging with PET and CMR. 6 June 2010, Society of Nuclear Medicine’s 57nd Annual Meeting, Salt Lake   City, Utah, USA. 
    35. Cardiovascular Basic PET Quantification and Modelling. 8 June 2010, Society of Nuclear Medicine’s 57nd Annual Meeting, Salt Lake, City, Utah, USA. 
    36. Role of PET/CT in the Identification and Characterization of subclinical and clinically manifest CAD.  12 april 2010,Grand Rounds Lectures, University Hospital of Essen, West-German Heart Centre, Essen, Germany. 
    37. Non-Invasive Quantification of Cardiac Blood Flow: Prognosis of Absolute Myocardial Blood Flow Assessment. 15 march 2010, 59th annual meeting of the American College of Cardiology (ACC), Atlanta, USA.
  • Events +

    Grand Rounds Lectures

     

    1. Role of PET/CT and CT - Coronary Angiography in the Identification and Characterization of CAD. 26 September 2013, Universitätsklinikum Essen, Westdeutsches Herzzentrum, Essen, Germany.

    2.  Obesity, Endocannabinoids, and Coronary Circulatory Dysfunction as Functional Precursor of CAD. 22 May 2013, Johns-Hopkins Medical School, Department of Endocrinology and Metabolism, Baltimore, Maryland, USA.

    3. Possibilities of PET/CT and CT in the Identification and Characterization of CAD.11 April 2013, University Hospital of Heidelberg, Department of Internal Medicine and Cardiology, Germany.

    4. Myocardial perfusion imaging with SPECT, PET and hybrid imaging. 17 September 2012, PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences, University of Copenhagen, Denmark.

    5. Myocardial metabolism by radionuclide imaging techniques. 18 September 2012, PhD-course: Cardiovascular Imaging of the Danish Cardiovascular Research Academy and Faculty of Health Sciences, University of Copenhagen, Denmark. 

    6. The future challenge of Nuclear Cardiology. 6 July 2012, 13th National Symposium of the Chinese Society of Nuclear Cardiology. Taiyuan, Shanxi, China.

    7. Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process. 9th January 2012, Grand Rounds Lectures in Cardiology, The Montefiore University Hospital for Albert Einstein College of Medicine, Bronx, New York, USA.

    8. Contribution of Cardiac PET/CT for the Detection and Monitoring of CAD Process. 10th January 2012, Grand Rounds Lectures in Nuclear Medicine, The Montefiore University Hospital for Albert Einstein College of Medicine, Bronx, New York, USA.

    9. Contributions of PET/CT in Assessing Coronary Physiology and Abnormalities as Functional Precursor of the CAD Process. 14 september 2011, University of Ottawa, National Heart Institute, Ottawa, Canada. 

    10. Role of PET/CT in the Identification and Characterization of the CAD Process. 22 june 2010, 11th National Symposium of the Chinese Society of Nuclear Cardiology. Ychang, China.

    11. Role of PET/CT in the Identification and Characterization of subclinical and clinically manifest CAD.    12 april 2010, Grand Rounds Lectures, University Hospital of Essen, West-German Heart Centre, Essen, Germany.

  • Contact & Locations +

    Department/Division

    • Radiology and Radiological Science - Nuclear Medicine

    For Research Inquiries Contact

    Thomas H. Schindler, MD
    Director of Cardiovascular Nuclear Medicine, Associate Professor PER at Johns Hopkins University
    Department of Radiology SOM, Nuclear Medicine, c/o Alexis Simich
    JHOC 3225, 601 N. Caroline Street, Baltimore, MD, 21287
    Phone: 410-955-8994; Fax: 443-287-2933. e-mail: tschind3@jhmi.edu

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