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Alison Patricia Klein, M.H.S., Ph.D.

Photo of Dr. Alison Patricia Klein, M.H.S., Ph.D.

Associate Professor of Oncology

Research Interests: Genetic Epidemiology; Pancreatic Cancer; Risk assessment; Familial Cancer Syndromes; Inherited cancer susceptibility

Background

Alison Klein, Ph.D., M.H.S. joined the pancreatic cancer research team in November 2004. Dr. Klein received her B.S. in Biology from Boston College in 1994. In 1999, she received her M.H.S. in Biostatistics and in 2001, her Ph.D. in Epidemiology, both from the Johns Hopkins School of Public Health. From 2001 to 2004, she was a research fellow in the Statistical Genetics Section, Inherited Disease Research Branch of the National Human Genome Research Institute, National Institutes of Health. Dr. Klein is an Assistant Professor of Oncology in the Sidney Kimmel Comprehensive Cancer Center here at Johns Hopkins and is the Director of the National Familial Pancreas Tumor Registry, which was founded in 1994. Working with Dr. Ralph Hruban, she will oversee the maintenance and further development of the registry and provide statistical analyses of the registry population. Dr. Klein's work will focus on the genetic epidemiology of pancreatic cancer in collaboration with Drs. Scott Kern, Michael Goggins and Ralph Hruban.

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Titles

  • Associate Professor of Oncology
  • Associate Professor of Pathology

Education

Degrees

  • B.S., Boston College (Massachusetts) (1994)
  • M.H.S., Johns Hopkins Bloomberg School of Public Health (Maryland) (1999)
  • Ph.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (2001)

Research & Publications

Research Summary

Dr. Klein is the Director of the National Familial Pancreas Tumor Registry, the largest pancreatic cancer family registry in the world (www.nfptr.org). She is a genetic epidemiologist with a focus on cancer research. Her current work focuses on the identification the genetic and environmental risk factors for pancreatic cancer as well as other complex genetic diseases. Recently, in the first demonstration that whole exome sequencing approaches can be used to identify the causes of a hereditary disease, she discovered that mutations in the PALB2 gene increase the risk of pancreatic cancer. In addition, she has developed a clinical risk assessment tool for high-risk pancreatic cancer families, PancPRO in order to facilitate the translation of her research findings into the clinical setting.

Selected Publications

Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR*, Goggins M*, Klein AP*. Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene. Science. 2009 Apr 10;324(5924):217. Epub 2009 Mar 5.

Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, Goggins M, Vogelstein B, Papadopoulos N, Hruban RH, Kinzler, KW, Klein AP. ATM Mutations in Patients with Hereditary Pancreatic Cancer. Cancer Discovery 2012(2)41

Roberts NJ, Norris AL, Petersen GM, Bondy ML Brand R, Gallinger S, Kurtz R, Olson SH, Rustgi AN, Schwartz A, Stoffel E, Syngal S, Zogopoulos G, Ali SZ, Axilbund J, Chaffee K, Chen YC, Cote ML, Childs EJ, Douville C, Goes FS, Herman JM, Iacobuzio-Donahue C, Kramer M, Makohon-Moore A, McCombie RW, McMahon, KW, Niknafs N, Parla J, Pirooznia, Potash J, Rhim AD, Smith AL, Wang Y, Wolfgang CL, Wood LD, Zandi PP, Goggins MG, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP. Cancer Discov. 2016 Feb;6(2):166-75. doi: 10.1158/2159-8290.CD-15-0402. Epub 2015 Dec 9. PubMed PMID: 26658419; PubMed Central PMCID: PMC4744563.

Childs EJ*, Mocci E*, Campa D*, Bracci PM, Gallinger S, Goggins M, Li D, Neale R, Olson SH, Scelo G, Amundadottir LT, Bamlet WR, Bijlsma MF, Blackford A, Borges M, Brennan P11, Brenner H, Bueno-de-Mesquita HB, Canzian F, Capurso G, Cavestro GM, Chaffee KG, Chanock SJ12, Cleary SP, Cotterchio M, Foretova L, Fuchs C, Funel N, Gazouli M, Hassan M, Herman JM, Holcatova I, Holly EA, Hoover RN, Hung RJ, Janout V, Key TJ, Kupcinskas J, Kurtz RC, Landi S, Lu L, Malecka-Panas E, Mambrini A, Mohelnikova-Duchonova B, Neoptolemos JP, Oberg AL, Orlow I, Pasquali C, Pezzilli R, Rizzato C, Saldia A, Scarpa A, Stolzenberg-Solomon RZ, Strobel O, Tavano F, Vashist YK, Vodicka P, Wolpin BM, Yu H, Petersen GM, Risch HA, Klein AP Common variation at at 17q25.1, 3q29, 7p13, and 2p13.3 associated with susceptibility of pancreatic cancer. Nature Genetics,

Wang W, Chen S, Hruban RH, Parmigiani G, Klein AP. PancPRO:risk assessment for individuals with a family history of pancreatic cancer. JCO 2007 Apr 10;25(11): 1417-1422

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