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Rosanne Rouf, M.D.
Assistant Professor of Medicine
Languages: English, Bengali
Expertise: Cardiac Transplant, Cardiomyopathy, Cardiovascular Disease, Congestive Heart Failure, Heart Failure, Heart Transplant, Inherited Heart Diseases, Peripartum Cardiomyopathy ...read more
Research Interests: The role of matricellular proteins in modulating cardiac fibrosis and heart failure
The Johns Hopkins Hospital
600 N. Wolfe Street
Ross Research Building, Suite 809
Baltimore, MD 21287 map
Johns Hopkins Outpatient Center
601 N. Caroline St.
Baltimore, MD 21287 map
Dr. Rosanne Rouf is a cardiologist with expertise in the medical care of heart failure and heart transplant patients. Her research interests include the role of gene expression in heart failure and in heart defects related to Marfan and Loeys-Deitz syndromes.
Dr. Rouf received her undergraduate and master’s degrees in electrical engineering and computer science from the Massachusetts Institute of Technology. She graduated from the Duke University School of Medicine, and completed her residency at the Tufts Medical Center. Dr. Rouf pursued fellowships at Tufts and Johns Hopkins, joining the faculty of the Johns Hopkins School of Medicine in 2011.
- Assistant Professor of Medicine
- MD, Duke University School of Medicine (2002)
- Tufts -New England Medical Center Hospitals / Internal Medicine (2005)
- Johns Hopkins University School of Medicine / Cardiology (2010)
- American Board of Internal Medicine / Cardiovascular Disease
Research & Publications
Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, Ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC. Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan 2;124(1):448-60.
Gould RA, Sinha R, Aziz H, Rouf R, Dietz HC 3rd, Judge DP, Butcher J. Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome. PLoS One. September 11, 2012; 7(9):e44639.
Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGFb signaling. Proceedings of the National Academy of Sciences. March 8, 2012.
Judge DP, Rouf R, Habashi J, Dietz HC. Mitral valve disease in Marfan syndrome and relate disorders. Journal of Cardiovascular Translational Research. August 25, 2011.
Judge DP, Rouf R. Use of genetics in the clinical evaluation and management of heart failure. Current Treatment Options in Cardiovascular Medicine. December 2010; 12(6):566-77.
Blaha MJ, Bansal S, Rouf R, Golden SH, DeFilippis AP, Blumenthal RS. A practical ‘ABCDE' approach to treating the metabolic syndrome. Mayo Clinic Proceedings. August 2008; 83(8):932-41.
Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Dillman WH, Patten RD, Huggins GS. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circulation Research. August 29, 2008;102(5):493-501.
Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO, Jr. BeyondLDL Cholesterol—Defining the role of LDL heterogeneity in coronary artery disease. Journal of American College of Cardiology. October 30, 2007; 50:1735-1741.
Activities & Honors
- Stanley J. Sarnoff Fellowship, 1999 - 2000
- Travel Grant, Heart Failure Society of America , 2005
- NIH/NRSA Post-doctoral Research Fellowship, Molecular Cardiology Research Institute, 2005
- Council on Clinical Cardiology Fellowship Travel Grant, American Heart Association, 2007
- Case Study Finalist, Mechanical Circulatory Support in Advanced Heart Failure Conference, 2008
- Women in Cardiology Trainee Award for Excellence, American Heart Association, 2008
- Sarnoff Scholar Fellow-to-Faculty Transition Award (4-year award; one awarded nationally every two years), 2009
- Stanley L. Blumenthal Cardiology Research Award, First Prize in Basic Science, 2010
- W. W. Smith Heart Research Award, 2011
- Young Investigator Award, International Congress of Human Genetics , 2011
- Johns Hopkins University School of Medicine Clinician Scientist Award (1 of 5 awarded institutionally in 2012), 2012
- American Heart Association, 2006
Videos & Media
Lectures and Presentations
Interrogation of sex differences in myxomatous mitral valve disease
Annual Scientific Meeting of the Leducq MITRAL Transatlantic Consortium , Boston (01/09/2010)
Fibrillin-1 is an active extracellular entity necessary for normal cardiac function
31st Annual Scientific Meeting of the Stanley J , National Harbor (01/28/2011)
Sarnoff Endowment for Cardiovascular Science
Gender influences mitral valve disease and response to therapy in Marfan mice
Annual Scientific Meeting of the Leducq MITRAL Transatlantic Consortium , Madrid (01/02/2011)
TAC’kling Marfan Cardiomyopathy: Novel insights regarding pathogenesis and treatment of heart failure
Division of Cardiology Grand Rounds , Baltimore (01/21/2012)
Johns Hopkins Hospital