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Rosanne Rouf, M.D.
Director, Outpatient Heart Failure Program
Assistant Professor of Medicine
Specializes in: Adults (18+ years), Geriatrics (55+ years)
Languages: English, Bengali
Expertise: Cardiac Transplant, Cardiomyopathy, Cardiovascular Disease, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Critical Care Cardiology, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Inherited Heart Diseases, Peripartum Cardiomyopathy, Stress-induced Cardiomyopathy ...read more
Research Interests: Genetic predisposition to cardiomyopathy and cardiotoxicity; nonmyocyte biology in heart failure
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Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-0270
4940 Eastern Avenue
Baltimore, MD 21224 map
Contact for Research Inquiries
Johns Hopkins University School of Medicine
720 Rutland Avenue
Baltimore, MD 21205 map
Rosanne Rouf, MD is Director of the outpatient Heart Failure Program at Johns Hopkins Bayview Medical Center and an Assistant Professor in the School of Medicine. Her research focuses on the nonmyocyte biology of heart failure and sex differences in valvular heart disease. She examines the role of hormones and gene dosage in the manifestation of pathological cardiovascular phenotypes and uses preclinical models to devise pharmacologic and gene-targeted strategies to ameliorate disease. Clinically, she is an Advanced Heart Failure cardiologist and sees patients at Johns Hopkins Bayview.
Dr. Rouf received her undergraduate and master’s degrees in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology. She graduated from the Duke University School of Medicine and completed her residency at the Tufts Medical Center. Dr. Rouf pursued cardiology training at Johns Hopkins, joining the faculty of the Johns Hopkins School of Medicine in 2011.
- Director, Outpatient Heart Failure Program
- Assistant Professor of Medicine
- MD, Duke University School of Medicine (2002)
- Tufts -New England Medical Center Hospitals / Internal Medicine (2005)
- Johns Hopkins University School of Medicine / Cardiology (2010)
- American Board of Internal Medicine / Advanced Heart Failure and Transplant Cardiology (2016)
- American Board of Internal Medicine / Cardiovascular Disease
Research & Publications
Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, Ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC. Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan 2;124(1):448-60.
Gould RA, Sinha R, Aziz H, Rouf R, Dietz HC 3rd, Judge DP, Butcher J. Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome. PLoS One. September 11, 2012; 7(9):e44639.
Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGFb signaling. Proceedings of the National Academy of Sciences. March 8, 2012.
Judge DP, Rouf R, Habashi J, Dietz HC. Mitral valve disease in Marfan syndrome and relate disorders. Journal of Cardiovascular Translational Research. August 25, 2011.
Judge DP, Rouf R. Use of genetics in the clinical evaluation and management of heart failure. Current Treatment Options in Cardiovascular Medicine. December 2010; 12(6):566-77.
Blaha MJ, Bansal S, Rouf R, Golden SH, DeFilippis AP, Blumenthal RS. A practical ‘ABCDE' approach to treating the metabolic syndrome. Mayo Clinic Proceedings. August 2008; 83(8):932-41.
Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Dillman WH, Patten RD, Huggins GS. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circulation Research. August 29, 2008;102(5):493-501.
Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO, Jr. BeyondLDL Cholesterol—Defining the role of LDL heterogeneity in coronary artery disease. Journal of American College of Cardiology. October 30, 2007; 50:1735-1741.
Houston BA, Vaishnav J, Schneider AL, Cromwell DM, Mille PE, Shah A, Sciortino C, Whitman G, Tedford RJ, Stevens GR, Judge DP, Russell SD, Rouf R. Angiotensin II Antagonism is Associated with Reduced Risk for Gastrointestinal Bleeding Due to Arteriovenous Malformations in Patients With Left Ventricular Assist Device. Journal of Heart and Lung Transplantation. 2017 Apr; 36(4):380-385.
Activities & Honors
- Stanley J. Sarnoff Scholar Award, 2009
- Stanley L. Blumenthal Cardiology Research Award, First Prize in Basic Science, 2010
- International Congress of Human Genetics Young Investigator Award, 2011
- Johns Hopkins University School of Medicine Clinician Scientist Award, 2012
- W. Leigh Thompson Excellence in Research Faculty Award, Johns Hopkins Department of Medicine, 2016
- Junior Faculty Basic Research Award-Finalist, Northwestern Young Investigators’ Forum, 2015
- American Heart Association, 2006
Videos & Media
Lectures and Presentations
Interrogation of sex differences in myxomatous mitral valve disease
Lecture , Annual Scientific Meeting of the Leducq MITRAL Transatlantic Consortium , Boston, MA (01/09/2010)
Gender influences mitral valve disease and response to therapy in Marfan mice
Lecture , Annual Scientific Meeting of the Leducq MITRAL Transatlantic Consortium , Madrid, Spain (01/02/2011)