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Kevin J. Yarema, Ph.D.
Associate Professor of Biomedical Engineering
Research Interests: Developing applications, such as cancer treatment, for metabolic oligosaccharide engineering methodologies; Systems biology approaches for determining the role of glycosylation in health and disease ...read more
Dr. Kevin Yarema is an associate professor of biomedical engineering at the Johns Hopkins University School of Medicine. His research focuses on biotechnology and clinical aspects of carbohydrate engineering.
After completing an undergraduate degree in bioengineering at Walla Walla College, Dr. Yarema went on to receive a Ph.D. in biological chemistry at the Massachusetts Institute of Technology. He then completed a postdoctoral fellowship at the University of California, Berkeley, where he specialized in chemical biology approaches for manipulating glycosylation in living cells.
Dr. Yarema uses systems biology approaches to determine the role of glycosylation in health and disease, and to develop applications—such as cancer treatment—for metabolic oligosaccharide engineering methodologies.
Dr. Yarema has authored or co-authored over 50 peer-reviewed articles and 25 book chapters or review articles. He has lectured and presented his work at universities and conferences throughout the world.
- Associate Professor of Biomedical Engineering
Departments / Divisions
- B.S., Walla Walla College (Washington) (1988)
- Ph.D., Massachusetts Institute of Technology (Massachusetts) (1994)
Research & Publications
The goals of research in Dr. Yarema’s Laboratory of Cell and Carbohydrate Engineering include:
- Develop sugar analogs into viable and versatile drug candidates
- Apply metabolic glycoengineering to tissue engineering and stem cell research
- Use non-invasive magnetic stimuli to probe the effects of glycoengineering (and also to treat neurological disorders).
- Extend our sugar-based drug candidates into animal models and the clinic
Lab Website: Yarema Laboratory
Selected PublicationsView all on Pubmed
Wang Z, Sarje A, Che P-L, & Yarema KJ. "Moderate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells." BMC Genomics. 2009; 10:356
Krambeck FJ, Bennun SV, Narang S, Choi SS, Yarema KJ, & Betenbaugh MJ. "A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data." Glycobiology. 2009 19:1163–1175.
Elmouelhi N, Aich U, Paruchuri VDP, Meledeo MA, Campbell CT, Wang JJ, Srinivas R, Khanna HS, & Yarema KJ. "Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery." J Med Chem. 2009; 52:2515–2530.
Sampathkumar S-G, Li AV, Jones MB, Sun Z, & Yarema KJ. "Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology." Nat Chem Biol. 2006; 2:149–152.
Campbell CT, Sampathkumar S-G, Weier C, & Yarema KJ. "Metabolic oligosaccharide engineering: perspectives, applications, and future directions." Mol Biosyst. 2007; 3:187–194.