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Photo of Dr. Lyle Ostrow

Lyle Wilfred Ostrow, M.D., Ph.D.

Assistant Professor of Neurology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Assistant Professor of Neurology

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-502-6165

600 N. Wolfe Street
The John G. Rangos Sr. Building Suite 248
Baltimore, MD 21287 map
Phone: 410-502-6165
Fax: 410-502-5459


Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD), Muscular Dystrophies, Myasthenia Gravis, Myopathy, Neurology, Neuromuscular Pathology, Peripheral Neuropathies

Research Interests

The role of astrocytes in ALS


Dr. Lyle Ostrow sees patients with a broad range of diseases of nerve and muscle, including amyotrophic lateral sclerosis (ALS), chronic inflammatory polyneuropathy (CIDP), peripheral neuropathies, muscular dystrophies and myopathies, myositis, and myasthenia gravis.

Dr. Ostrow's laboratory research focuses on the role of astrocytes in amyotrophic lateral sclerosis (ALS) and other neurologic disorders. He is investigating whether abnormally increased production of a protein called endothelin by astrocytes may represent a novel therapeutic target in ALS. He also studies ways in which astrocytes sense and respond to mechanical stress, and how this may be involved in several neurologic diseases.

Dr. Lyle Ostrow received his M.D. degree and a Ph.D. in Biophysics from the State University of New York at Buffalo. He completed an Internal Medicine Internship at Johns Hopkins Bayview Medical Center, followed by Neurology Residency training at The Johns Hopkins Hospital. After residency, Dr. Ostrow completed a fellowship in Neuromuscular Medicine also at Johns Hopkins. more

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