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Photo of Dr. Lyle Ostrow

Lyle Wilfred Ostrow, MD PhD

Assistant Professor of Neurology

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Appointment Phone


Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Assistant Professor of Neurology

Centers & Institutes

  • Amyotrophic Lateral Sclerosis (ALS) Clinic
  • Muscular Dystrophy Association Center
  • Peripheral Nerve Center


Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD), Muscular Dystrophies, Myasthenia Gravis, Myopathy, Neurology, Neuromuscular Pathology, Peripheral Neuropathies

Research Interests

The role of astrocytes in ALS


Dr. Lyle Ostrow sees patients with a broad range of diseases of nerve and muscle, including amyotrophic lateral sclerosis (ALS), chronic inflammatory polyneuropathy (CIDP), peripheral neuropathies, muscular dystrophies and myopathies, myositis, and myasthenia gravis.

Dr. Ostrow's laboratory research focuses on the role of astrocytes in amyotrophic lateral sclerosis (ALS) and other neurologic disorders. He is investigating whether abnormally increased production of a protein called endothelin by astrocytes may represent a novel therapeutic target in ALS. He also studies ways in which astrocytes sense and respond to mechanical stress, and how this may be involved in several neurologic diseases.

Dr. Lyle Ostrow received his M.D. degree and a Ph.D. in Biophysics from the State University of New York at Buffalo. He completed an Internal Medicine Internship at Johns Hopkins Bayview Medical Center, followed by Neurology Residency training at The Johns Hopkins Hospital. After residency, Dr. Ostrow completed a fellowship in Neuromuscular Medicine also at Johns Hopkins.
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