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Steven Zeiler, M.D., Ph.D.

Steven Robert Zeiler, M.D., Ph.D.
Director, Vascular Neurology Fellowship Program
Assistant Professor of Neurology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Vascular Neurology Fellowship Program
  • Assistant Professor of Neurology

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-614-2381

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-614-2381

4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-614-2381

601 N. Caroline Street
Baltimore, MD 21287 map


Acute Stroke Care, Cerebrovascular Diseases, Neurology, Stroke, Stroke Prevention

Research Interests

Stroke recovery


Dr. Steven Zeiler focuses on the diagnosis and management of cerebrovascular disease (stroke), including acute stroke therapy, secondary prevention of stroke, and recovery from stroke.

Dr. Steven Zeiler received his medical and doctor of philosophy degrees from the University of Colorado. He completed a one year internal medicine internship at the University of Colorado prior to coming to Johns Hopkins for his residency training in Neurology. Following his residency, Dr. Zeiler then completed a one year fellowship in Vascular Neurology also at Johns Hopkins. more

Featured Video

Stroke Surgery - Tabatha's Story

    Additional Information

  • Education +


    • University of Colorado Health Sciences Center / MD (2005)


    • Johns Hopkins University School of Medicine / Neurology (2009)


    • Johns Hopkins University School of Medicine / Neurology (2010)


    • American Board of Psychiatry & Neurology / Neurology (2009, 2019)
    • American Board of Psychiatry & Neurology / Vascular Neurology (2011)
  • Research & Publications +

    Research Summary

    Principal investigator, Johns Hopkins Department of Neurology 2010 to present
    Assessment of post-stroke neocortical plasticity using a multi-modal approach in the motor and visual cortices.

    Postdoctoral fellowship, University of Colorado at Boulder 2002 to 2003
    Advisor: Kevin Jones, Ph.D
    Title: Brain Derived Neurotrophic Factor Signaling in Murine Visual Cortex.
    Continuing upon my thesis research, I further described part of the biochemical signaling pathway through which brain derived neurotrophic factor signals to influence visual cortical plasticity.

    Thesis project research, University of Colorado at Boulder 1998 to 2002
    Advisor: Kevin Jones, Ph.D
    Using genetic knockout mouse technology, I characterized the requirements for brain derived neurotrophic factor in the development and plastic changes of murine visual cortex.

    Eleanor Roosevelt Institute 1998
    Adviosr: Kathleen Gardiner, Ph.D.
    Using several different computer algorithms, I annotated genes on chromosomes 21 and 22 and subsequently validated gene godels using reverse transcriptase-polymerase chain reaction and sequencing techniques. I also analyzed the 3’ untranslated regions of the glutamate receptor family.

    Undergraduate research, University of Colorado at Boulder 1995 to 1996
    Advisor: William B. Wood, Ph.D.
    I studied P granules, organelles asymmetrically segregated during early development of the C. elegans embryo, via cloning, characterization, and genetic mapping of a gene likely to be a P granule component.

    Clinical Trials:

    To learn more about our current cerebrovascular clinical trials, please visit The Johns Hopkins Institute for Clinical and Translational Research (ICTR) and enter "cerebrovascular" in the search box.

    Selected Publications View all on PubMed

    Zeiler, S. R., Krakauer, J.W. The interaction between training and plasticity in the poststroke brain. Curr Opin Neurol. Curr Opin Neurol. 2013 Oct 16. [Epub ahead of print]

    Zeiler, S. R., Gibson, E. M., Hoesch, R. E., Li, M. Y., Worley, P. F., O'Brien, R. J., Krakauer, J. W. Medial Premotor Cortex Shows A Reduction In Inhibitory Markers And Mediates Recovery In A Mouse Model Of Focal Stroke. Stroke. 2013 Feb;44(2):483-9.

    Han, Y., Li, N., Zeiler, S. R., Pelled, G. Peripheral nerve injury results in immediate increases in lamina V neuronal activity. (in press). Neurorehabilitation and Neural Repair.

    Qiao, Y., Zeiler, S. R., Mirbagheri, S., Leigh R., Urrutia, V., Wityk, R., Wasserman, B. A., Intracranial Plaque Enhancement in Patients with Cerebrovascular Events: Initial Results using 3D High Resolution Vessel Wall MRI. (epub – ahed of print) Radiology.

    Zeiler, S. R., Gorski, J. A., Jones, K. R. (in revision for European J.Neurosci) BDNF acts as an activity dependent survival and modification factor for visual cortical synapses.

    Marshall, S. A., Zeiler, S. R., Nyquist, P. A. The Use of Permissive Hypercapnia in the setting of Hypoxic Ischemic Encephalopathy and ARDS: a brief case discussion regarding the use of lung protective ventilation in the setting of anoxic brain injury and eventual patient outcome. In preparation for The Neurologist.

    Chik, Y, Gottesman R. F., Zeiler S. R., Rosenberg, J., Llinas R. H. Differentiation of Transverse Sinus Thrombosis From Congenitally Atretic Cerebral Transverse Sinus With CT. Stroke. 2012 Jul;43(7):1968-70. Epub 2012 May 15

    Marsh, E.B., Zeiler, S.R., Levy, M., Llinas, R.H., Urrutia, V.C. Diagnosing CNS Vasculitis: the case against empiric treatment. Neurologist. 2012 Jul;18(4):233-8.

    Qiao Y., Etesami M., Astor B.C., Zeiler S.R., Trout H.H. 3rd, Wasserman B.A. Carotid Plaque Neovascularization and Hemorrhage Detected by MR Imaging are Associated with Recent Cerebrovascular Ischemic Events. Am J Neuroradiol. 2012 Apr;33(4):755-60. Epub 2011 Dec 22.

    Zeiler, S. R., Turtzo, C.L., Kaplan, P. W. SPECT Negative SIRPIDs Mimicking a Stroke After Cardiac Arrest. J Clin Neurophysiol. 2011 Oct;28(5):493-6.

    Zeiler, S. R., Jordan, J. D., Greenberg, B. M., Kaplan, P. K. ANNA-3 Associated Stiff-Person-Syndrome. J. Cancer and Science Therapy. 2009 Vol. 2 Issue 1; 1 – 2.

    Zeiler, S. R., Kaplan, P. W. Our digital world: camera phones and the diagnosis of a seizure. Lancet. 2009 Jun 20;373(9681):2136.

    Zeiler S. R., Kaplan P. W. (2008) Propofol withdrawal seizures (or not). Seizure. 2008 Oct;17(7):665-7. Epub 2008 May 14

    Gorski J. A., Zeiler S. R., Tamowski S., Jones K. R. (2003). Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci. Jul 30;23(17):6856-65.

    Akbarian, S., Rios, M., Liu, R-J., Gold, S., Fongl, H., Zeiler, S., Coppola, V., Tessarollo, L., Jones, K., Nestler, E. J., Aghajanian, G. K., Jaenisch, R. (2002). Brain-Derived Neurotrophic Factor is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons. J Neurosci. May 15;22 (10):4153-62.

    Bennett J. L., Zeiler S. R., Jones K. R. (1999). Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye. Invest Ophthalmol Vis Sci, Nov;40(12):2996-3005

    Read the latest research papers that Dr. Zeiler has published at PubMed.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Kittredge Honors Program, 1992 - 1994
    • National Science Scholar and Scholarship, 1992 - 1996
    • Alpha Epsilon Delta Honors Society, 1993 - 1996
    • Kittredge Honors Scholarship, 1993 - 1994
    • Univery of Colorado Kittredge Honors Award, 1993 - 1996
    • Dean''s Scholar and Scholarship, 1994 - 1996
    • Golden Key National Honor Society, 1994 - 1996
    • Mortar Board, 1995 - 1996
    • Phi Beta Kappa, 1995
    • Summa Cum Laude, 1996
    • Academic Excellence Award, University of Colorado, 1997 - 1998
    • Rocky Mountain Neuroscience Conference Annual Student Achievement Award, 2001
    • Jahnigen Award, 2003
    • Junior and Senior Alpha Omega Alpha (AOA) Medical Honors Society, 2004
    • American Academy of Neurology Extended Neuroscience Award, 2005
    • Osler Housestaff Teaching Award, 2008
    • Fellow Scholarship, Annual American Neurological Association Meeting, 2009
    • Guy McKhann teaching Award, 2009
    • Jay Slotkin Research Award, 2009
    • Resident Scholarship, Annual American Academy of Neurology Meeting, 2009
    • DeFord Teaching Excellence Award, Johns Hopkins Neurology Residency, 2011
    • Teaching Excellence Award, Johns Hopkins University Medical Student Award, 2011
    • Osler Housestaff Teaching Award, 2012


    • American Academy of Neurology, 2005
    • American Heart Association, 2013
    • Society for Neuroscience, 2012
    • Student Interest Group in Neurology (S.I.G.N), 2003 - 2004
  • Videos & Media +

    Lectures and Presentations

    Timing, Training, and Biological Determinants of Post-Stroke Recovery.
    West Virginia (01/01/2014)
    West Virginia University, Department of Neurology Grand Rounds

    Timing, Training, and Biological Determinants of Post-Stroke Recovery.
    Baltimore (01/01/2013)
    Johns Hopkins, Department of Neurology Grand Rounds

    Timing, Training, and Biological Determinants of Post-Stroke Recovery.
    Baltimore (01/01/2013)
    Good Samaritan Hospital, Department of Medicine Grand Rounds

    Interaction between post-stroke plasticity, rehabilitation, and functional recovery; from rodents to humans.
    Peurtro Rico (01/01/2014)
    Winter Conference on Neuroplasticity

    Stroke and Vasculitis; How to Help, How to Harm. Medical Grand Rounds
    Baltimore (01/01/2013)
    Good Samaritan Hospital

    Stroke and Vasculitis; How to Help, How to Harm. Neuroscience Grand Rounds.
    Baltimore (01/01/2013)
    Greater Baltimore Medical Center

    Stroke and Vasculitis; How to Help, How to Harm. Neurovascular Case Review (division of Neuro-Interventional Surgery).
    Newark (01/01/2013)
    Christiana Care Hospital

    The Importance of Mouse Medial Premotor Cortex, Early Re-Training, and Fluoxetine In The Recovery From a Focal Stroke Induced Motor Deficit.
    New Orleans (01/01/2012)
    Platform presentation at Translational and Motor Control Satellite

    Recent News Articles & Media Coverage

    Antidepressant may help stroke patients with rehabilitation, United Press International (09/02/2015)

    A Moment's Notice: Coordinated advanced stroke care saves young patient, Johns Hopkins Bayview Health and Wellness News (Summer 2015)

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