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Ying Chen, Ph.D.

Photo of Dr. Ying Chen, Ph.D.

Assistant Professor of Radiology and Radiological Science

Research Interests: Cancer Imaging; Chemistry; Synthesis; Radiochemistry; Radiotherapy; Optical Imaging; Photodynamic Therapy

Contact for Research Inquiries

1550 Orleans Street,
CRBII Rm470
Baltimore, MD 21231 map

Background

Ying Chen, Ph.D., is an Assistant Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. Dr. Chen is a synthetic chemist with extensive experience in radiochemistry and optical imaging, specifically, in developing agents for imaging and treatment of cancers.

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Titles

  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • B.S., Nanjing University (China) (1994)
  • Ph.D., Nanjing University (China) (1999)

Research & Publications

Research Summary

Prostate cancer is one of the leading cancers in the U.S. population and the second leading cause of cancer death in men. Early detection is associated with better patient outcomes.  Prostate-specific membrane antigen (PSMA) is an excellent marker for prostate cancer because it is highly expressed in prostate cancer and in the neovasculature of solid tumors. Dr. Chen has been working on the design and synthesis of low-molecular-weight PSMA-based PET and SPECT imaging agents for imaging prostate cancer. One of the agents, [18F]DCFPyL, has been licensed by Progenics Pharmaceuticals, Inc and currently under Phase 2/3 clinical trial. The goal is to have a convenient set of tools for accurate staging and therapeutic monitoring. 

With the recent appearance of near-infrared (NIR) emitting optical dyes and highly sensitive cameras to detect them, optical imaging is beginning to be introduced to the operating room for intra-operative guidance. Dr. Chen has also been working on the design and synthesis PSMA-targeted NIR agent for human intraoperative guidance.

Selected Publications

Chen Y, Foss CA, Byun Y, Nimmagadda S, Pullambhatla M, Fox JJ, Castanares SE, Babich JW, Mease RC, Pomper MG. Radiohalogenated PSMA-based ureas as imaging agents for prostate cancer. Journal of Medicinal Chemistry 2008, 51, 7933-7943

Chen Y, Dhara S, Banerjee SR, Byun Y, Pullambhatla M, Mease RC, Pomper MG. A Low Molecular Weight PSMA-Based Fluorescent Imaging Agent for Cancer. Biochemical and Biophysical Research Communications 2009, 390, 624-629

Chen Y, Pullambhatla M, Foss CA, Byun Y, Nimmagadda S, Srinivasan S, Sgouros G, Mease RC, Pomper MG. 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET Imaging Agent for Prostate Cancer. Clin Cancer Res 2011, 17, 7645-7653

Chen Y, Pullambhatla M, Banerjee SR, Byun Y, Stathis M, Rojas C, Slusher BS, Mease RC, Pomper MG. Synthesis and biological evaluation of low molecular weight fluorescent imaging agents for the prostate-specific membrane antigen. Bioconjug Chem. 2012, 23, 2377-2385

Chen Y, Lisok A, Chatterjee S, Wharram B, Pullambhatla M, Wang Y, Sgouros G, Mease RC, Pomper MG. [18F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance. Bioconjugate chemistry 2016, 27, 1655-62

Activities & Honors

Memberships

  • Society of Nuclear Medicine and Molecular Imaging

Videos & Media

Lectures and Presentations

  • Positron-emitting PSMA inhibitors for molecular imaging of prostate cancer
    Presentation, Annual Meeting of Social of Nuclear Medicine, Washington DC (01/01/2008)
  • Synthesis and biological evaluation of PSMA-based near infrared fluorescent imaging agents for prostate cancer
    presentation, Annual Meeting of Social of Nuclear Medicine, San Antonio, Texas (01/01/2011)
  • Synthesis and biological evaluation of [18F]DCFPyL for PSMA-targeted imaging of prostate cancer
    presentation, Annual Meeting of Social of Nuclear Medicine, San Antonio, Texas (01/01/2011)
  • Synthesis and preclinical evaluation of two new 18F-labeled PSMA inhibitors prepared via click chemistry
    presentation, Baltimore, MD (01/01/2015)
    Annual Meeting of Social of Nuclear Medicine
  • A PSMA-Targeted Theranostic Agent for Prostate Cancer
    presentation, Baltimore, MD (01/01/2015)
    Annual Meeting of Social of Nuclear Medicine
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