Dr. Hall's research is focused on the role of the interferon (IFN) pathways in the pathogenesis of autoimmune rheumatic diseases. An important feature of rheumatic diseases is the rapid amplification of pathways of pathogenic significance. With a similar capacity to rapidly self-amplify, the IFN system may be an important player in the pathogenesis of these diseases. While significant evidence implicates IFNs in the pathogenesis of rheumatic disease, determining the distinct IFN pathways which are active in target tissues from patients with specific rheumatic diseases will be useful for selecting rational therapies for the treatment of these disorders. Working closely with clinical faculty members from Rheumatic Disease Specialty Centers, Dr. Hall is interested in defining cell type-specific responses to the different classes of IFN; interrogating the activity of the different IFN pathways in target tissues from patients with myositis, Sjögren's syndrome and scleroderma; identifying disease-specific gene signatures; and defining biomarkers of disease activity in rheumatic diseases.
Mammen AL, Casciola-Rosen L, Hall JC, Christopher-Stine L, Corse AM, and Rosen A. Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle. Arth Rheum 2009; 60: 3784-3793.
Hall JC and Rosen A. Type I interferons: Crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol 2010; 6: 40-49.
Casciola-Rosen L, Hall JC, Mammen AL, Christopher-Stine L, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: A potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012; 30(4): 548-553.
Cottrell TR, Hall JC, Rosen A, Casciola-Rosen L. Identification of novel autoantigens by a triangulation approach. J Immunol Methods. 2012; 385(1-2): 35-44.
Hall JC, Casciola-Rosen L, Berger AE, Kapsogeorgou EK, Cheadle C, Tzioufas AG, Baer AN, Rosen A. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases. Proc Natl Acad Sci U S A. 2012; 109(43): 17609-14.
Hall JC, Casciola-Rosen L, Samedy L, Werner J, Owoyemi K, Danoff SK, Christopher-Stine L. Anti-MDA5-Associated Dermatomyositis: Expanding the Clinical Spectrum. Arthritis Care Res (Hoboken). 2013 Aug;65(8):1307-15.