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George Sgouros, Ph.D.

Photo of Dr. George Sgouros, Ph.D.

Director, Radiopharmaceutical Dosimetry

Professor of Radiology and Radiological Science

Research Interests: Alpha-particle emitters; Pharmacokinetic modeling; Dosimetry; Radioimmunotherapy; Targeted radionuclide therapy

Background

Dr. George Sgouros is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science, Department of Radiation Oncology and Department of Oncology and a member of the Johns Hopkins Kimmel Cancer Center. His research focuses on modeling and dosimetry of internally administered radionuclides with a particular emphasis on patient-specific dosimetry, alpha-particle dosimetry, and mathematical modeling of radionuclide therapy. Dr. Sgouros serves as the Director of Radiopharmaceutical Dosimetry.

Dr. Sgouros received his undergraduate degree in applied physics from Columbia University. He earned his Ph.D. from Cornell University and performed a fellowship in medical physics at Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center in New York. Dr. Sgouros joined the Johns Hopkins faculty in 2003.

Prior to joining Johns Hopkins, Dr. Sgouros was an Associate Professor in Radiology at Cornell University and an Associate Attending Physicist at Memorial Sloan-Kettering Cancer Center.

Dr. Sgouros' research interests include targeted radionuclide therapy, radioimmunotherapy, dosimetry, pharmacokinetic modeling, and alpha-particle emitters.

Dr. Sgouros serves as chairman of the Medical Internal Radionuclide Dose (MIRD) Committee as well as a steering committee member of the American Association of Physicists in Medicine (AAPM), Task Group on Internal Emitter Dosimetry. He has received a number of awards including the 2001 CaP CURE Award. Dr. Sgouros is a member of the National Council on Radiation Protection and Measurements (NCRP) Committee on Uncertainties in Internal Radiation Dosimetry.

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Titles

  • Director, Radiopharmaceutical Dosimetry
  • Professor of Radiology and Radiological Science
  • Professor of Oncology
  • Professor of Radiation Oncology and Molecular Radiation Sciences

Education

Degrees

  • B.S., Columbia University in the City of New York (New York) (1984)
  • Ph.D., Cornell University (New York) (1991)

Additional Training

Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center, New York, New York, 1993, Post-Doctoral Research Fellow (Medical Physics)

Research & Publications

Research Summary

Dr. Sgouros’ research over the past 20 years has focused on modeling and dosimetry of internally administered radionuclides with a particular emphasis on patient-specific dosimetry, alpha-particle dosimetry, and mathematical modeling of radionuclide therapy.

Lab

The Sgouros Radionuclide Therapy and Dosimetry Research Lab is focused on modeling and dosimetry analysis of radionuclide therapy to support the translation of novel targeted radionuclide therapy strategies to the clinic. The research is divided between laboratory studies and patient-specific dosimetry/radiobiological modeling studies. Dr. Sgouros’ lab is currently engaged in pre-clinical research investigating targeted alpha-emitter therapy of metastatic cancer.

Clinical Trials

Safety and Efficacy Study of I-131 Tositumomab in Patients With Relapsed/Refractory Hodgkin''s Lymphoma

Selected Publications

View all on Pubmed

  1. Hobbs RF, Wahl RL, Frey EC, Kasamon Y, Song H, Huang P, Jones RJ, Sgouros G. "Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-Hodgkin lymphoma." J Nucl Med. 2013 Sep;54(9):1535-42. doi: 10.2967/jnumed.112.117952. Epub 2013 Aug 5.
  2. Song H, Hedayati M, Hobbs RF, Shao C, Bruchertseifer F, Morgenstern A, Deweese TL, Sgouros G. "Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR Antibody." Mol Cancer Ther. 2013 Oct;12(10):2043-54. doi: 10.1158/1535-7163.MCT-13-0108. Epub 2013 Jul 19.
  3. Cheng L, Hobbs RF, Segars PW, Sgouros G, Frey EC. "Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters." Phys Med Biol. 2013 Jun 7;58(11):3631-47. doi: 10.1088/0031-9155/58/11/3631. Epub 2013 May 7.
  4. Meghzifene A, Sgouros G. "IAEA support to medical physics in nuclear medicine." Semin Nucl Med. 2013 May;43(3):181-7. doi: 10.1053/j.semnuclmed.2012.11.008.
  5. Hobbs RF, Jentzen W, Bockisch A, Sgouros G. "Monte Carlo-based 3-dimensional dosimetry of salivary glands in radioiodine treatment of differentiated thyroid cancer estimated using 124I PET." Q J Nucl Med Mol Imaging. 2013 Mar;57(1):79-91.

Activities & Honors

Honors

  • Invited faculty, International Atomic Energy Association (IAEA) Training Course on Medical Physics, 2007
  • Organizing Committee Member, International Symposium on Standards, 2009
  • Chairman, Medical Internal Radiation Dose (MIRD) Committee Society of Nuclear Medicine, 2008
  • Member, National Council on Radiation Protection and Measurements (NCRP), 2005
  • Oncological Sciences IRG Study Section Boundaries Team member, NIH, Center for Scientific Review, 2001
  • CaP CURE Award, 2001

Memberships

  • American Association of Physicists in Medicine (AAPM)
    Steering Committee Member, Task Group on Internal Emitter Dosimetry
  • National Council on Radiation Protection and Measurements (NCRP)
    Member, Committee on Uncertainties in Internal Radiation Dosimetry

Professional Activities

  • Chairman, Medical Internal Radionuclide Dose (MIRD) Committee
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