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Katharine Ashley Whartenby, Ph.D.

Photo of Dr. Katharine Ashley Whartenby, Ph.D.

Associate Professor of Neurology

Research Interests: Immunology; Neuroimmunology; Gene Transfer technology; Stem Cells



  • Associate Professor of Neurology
  • Associate Professor of Oncology



  • B.A., Amherst College (Massachusetts) (1986)
  • Ph.D., University of Rochester (New York) (1992)

Research & Publications


My lab is focused on understanding the biology of multiple sclerosis and neuroimmunology. In one area of investigation, we have been analyzing immunological mechanisms by which people with multiple sclerosis suffer from infectious disease complications. In addition, we have areas of investigation in basic immunology and in stem cell biology.

Selected Publications

  1. Accelerated axon loss in MOG35-55 experimental autoimmune encephalomyelitis (EAE) in myelin-associated glycoprotein-deficient (MAGKO) mice. Jones MV, Nguyen TT, Ewaleifoh O, Lebson L, Whartenby KA, Griffin JW, Calabresi PA. J Neuroimmunol. 2013 Sep 15;262(1-2):53-61. doi: 10.1016/j.jneuroim.2013.06.008. Epub 2013 Jul 27. PMID: 23899666
  2. Behavioral and pathological outcomes in MOG 35-55 experimental autoimmune encephalomyelitis. Jones MV, Nguyen TT, Deboy CA, Griffin JW, Whartenby KA, Kerr DA, Calabresi PA. J Neuroimmunol. 2008 Aug 13;199(1-2):83-93. doi: 10.1016/j.jneuroim.2008.05.013. Epub 2008 Jun 25. PMID: 18582952
  3. Induction of the glucocorticoid-induced leucine zipper gene limits the efficacy of dendritic cell vaccines. Lebson L, Wang T, Jiang Q, Whartenby KA. Cancer Gene Ther. 2011 Aug;18(8):563-70. doi: 10.1038/cgt.2011.23. Epub 2011 May 6. PMID: 21546924
  4. An open-label trial of combination therapy with interferon beta-1a and oral methotrexate in MS. Calabresi PA, Wilterdink JL, Rogg JM, Mills P, Webb A, Whartenby KA. Neurology. 2002 Jan 22;58(2):314-7. PMID: 11805267
  5. Recombinant interferon alpha2a synergistically enhances ganciclovir-mediated tumor cell killing in the herpes simplex virus thymidine kinase system. Whartenby KA, Darnowski JW, Freeman SM, Yurasha K, Calabresi P. Cancer Gene Ther. 1999 Sep-Oct;6(5):402-8. PMID: 10505850

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