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Geraldine Seydoux, Ph.D.

Photo of Dr. Geraldine Seydoux, Ph.D.

Professor of Molecular Biology and Genetics

Research Interests: Caenorhabditis elegans; Embryogenesis; Embryonic polarity and the soma-germline dichotomy

Contact for Research Inquiries

725 N. Wolfe Street
706 PCTB
Baltimore, MD 21205 map
Phone: 410-614-4622
Fax: 410-955-9124

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Background

Dr. Geraldine Seydoux is a professor of molecular biology and genetics at the Johns Hopkins University School of Medicine. Her work examines how early embryos develop into complex asymmetric structures comprising many cell types.

Her current reseearch uses the transparent worm C. elegans as a model system, and she has developed methods to film and measure protein dynamics in live embryos. Using genetics, biochemistry and quantitative microscopy, the Seydoux lab investigates how interactions between microtubules and the membrane cause complex protein networks to “self-organize” and polarize the entire embryo.

Dr. Seydoux received her B.S. in biochemistry from the University of Maine at Orono in 1986, and completed her Ph.D. in molecular biology at Princeton University in 1991. After a postdoctoral fellowship in developmental biology at the Carnegie Institute of Washington, she joined the faculty of Johns Hopkins in 1995 as an assistant professor. She became an associate professor in 2000, and accepted the mantle of full professor in 2004.

Dr. Seydoux has authored or co-authored numerous peer-reviewed publications and her work has garnered several awards, including a MacArthur Fellowship and a Kirsch Investigator Award. She is a member of the Society for Developmental Biology and the Genetic Society of America, and serves on the editorial boards of Developmental Cell, Development, and Worm Book.

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Titles

  • Professor of Molecular Biology and Genetics

Departments / Divisions

Education

Degrees

  • B.S., University of Maine (Maine) (1986)
  • Ph.D., Princeton University (New Jersey) (1991)

Additional Training

Carnegie Institute of Washington, Washington, D.C., 1995, Developmental Biology

Research & Publications

Research Summary

Geraldine Seydoux is a developmental biologist who studies how early embryos develop into complex asymmetric structures comprising many cell types. Geraldine uses the transparent worm C. elegans as a model system and has developed methods to film and measure protein dynamics in live embryos.

Her lab has found that the C. elegans embryo becomes polarized after fertilization when microtubules associated with the sperm come in contact with the plasma membrane. Using genetics, biochemistry and quantitative microscopy, the Seydoux lab is investigating how interactions between microtubules and the membrane cause complex protein networks to “self-organize” and polarize the entire embryo.

Lab

The Seydoux lab studies the earliest stages of embryogenesis to understand how single-celled eggs develop into complex multicellular embryos. The researchers focus on the choice between soma and germline, one of the first developmental decisions faced by embryos.

The goal of Seydoux’s research is to identify and characterize the molecular mechanisms that activate embryonic development, polarize embryos, and distinguish between somatic and germline cells.

Lab Website: Seydoux Lab

Selected Publications

View all on Pubmed

  1. Voronina E, Paix A, Seydoux G. "The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells." Development. 2012 Oct;139(20):3732-40.
  2. Griffin EE, Odde DJ, Seydoux G. "Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle." Cell. 2011 Sep 16;146(6):955-68. doi: 10.1016/j.cell.2011.08.012.
  3. Motegi F, Zonies S, Hao Y, Cuenca AA, Griffin E, Seydoux G. "Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes." Nat Cell Biol. 2011 Oct 9;13(11):1361-7. doi: 10.1038/ncb2354.
  4. Gallo CM, Wang JT, Motegi F, Seydoux G. Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science. 2010 Dec 17;330(6011):1685-9. doi: 10.1126/science.1193697. Epub 2010 Dec 2.
  5. Voronina E, Seydoux G. "The nucleoporin NPP-10/Nup98 is required for the integrity and function of germline P granules." Development. 2010, 137, 1441-1450.
  6. Cheng K, Klancer R, Singson A, Seydoux G. "Regulation of MBK-2/DYRK by CDK-1 and the pseudo-phosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition." Cell. 2009, 139(3):560-72.
  7. Merritt C, Rasoloson D, Ko D, Seydoux G. "3¹ UTRs are the primary regulators of gene expression in the C. elegans germline." Current Biology, 2008, 18(19):1476-82.
  8. Stitzel M, Seydoux G. "Regulation of the oocyte-to-zygote transition." Science. 2007, 316, 407-8.
  9. Seydoux G, Braun R. "Pathway to totipotency: lessons from germ cells." Cell. 2006, 127, 891-904.

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program

Human Genetics and Molecular Biology

Courses and Syllabi

  • Molecules and Cells, (Instructor)
    1996
  • Fundamentals of Genetics, (Instructor)
    1997
  • Development Biology Elective, (Instructor)
    2004
  • Epigenetics Elective, (Instructor)
    2004
  • Fundamentals of Genetics, (Course Director)
    2003

Activities & Honors

Honors

  • Junior Faculty Research Award, American Cancer Society, 1996 - 1999
  • Basil O'Connor Starter Scholar Research Award, March of Dimes, 1996 - 1998
  • Presidential Early Career Award for Scientists and Engineers (PECASE), National Institutes of Health, 1999
  • Kirsch Investigator Award, Steve and Michele Kirsch Foundation, 2001 - 2003
  • Searle Scholar Program, The Chicago Community Trust, 1996
  • Summa Cum Laude, University of Maine, 1986
  • Totman Scholarship, University of Maine, 1985 - 1986
  • MacArthur Fellowship, 2001
  • David and Lucile Packard Fellowship for Science and Engineering, 1995
  • Helen Hay Whitney Post-Doctoral Fellowship, 1991
  • Howard Hughes Medical Institute Pre-Doctoral Fellowship, 1988
  • Princeton Fellowship, 1986
  • Alpha Zeta Honorary Fraternity, 1985
  • Phi Kappa Phi Honor Society, 1984

Memberships

  • Genetic Society of America
  • Society for Developmental Biology

Professional Activities

  • Ad Hoc Reviewer, NIH Reproductive Biology Study Section, 2002 - 2003
  • Ad Hoc Reviewer, NIH Genetics Study Section, 2001
  • Admissions Committee BCMB graduate program, Johns Hopkins University, 1997
  • BCMB graduate program Policy Committee, Johns Hopkins University, 2003
  • Biomedical Scholars Selection committee, Johns Hopkins University, 2000
  • Board of Directors, Genetic Society of America, 2005 - 2008
  • Editorial Board, Development, 2005
  • Editorial Board, Online review of C. elegans biology, 2004
    Worm Book
  • Editorial Board, Developmental Cell, 2002
  • Guest reviewer, Winchell Cancer Research Fund, 2001
    Damon Runyon
  • Medical School Council, Johns Hopkins University, 1998 - 2002
  • Medical School Council Agenda Committee, johns Hopkins University, 2001 - 2002
  • Review Panel, NSF Electronic Reviews, 1999
  • Review Panel for Post, Life Sciences Research Foundation, 2005 - 2008
    Doctoral Fellowships
  • Vice-chair, Johns Hopkins University, 2002 - 2003
    Radiology Search Committee
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