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Pamela Belmonte Mahon, Ph.D.

Photo of Dr. Pamela Belmonte Mahon, Ph.D.

Assistant Professor of Psychiatry and Behavioral Sciences

Research Interests: Mood disorders; Stress response; Aging; Neuroimaging; Genetics

Contact for Research Inquiries

The Johns Hopkins Hospital
Phipps Building
600 North Wolfe Street
Baltimore, MD 21287 map
Phone: 410-955-1382
Fax: 410-502-0065

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Background

Dr. Mahon received her PhD in Psychiatric Epidemiology from the Johns Hopkins Bloomberg School of Public Health.  She completed a postdoctoral fellowship in psychiatric genetics before being appointed to the faculty in the Department of Psychiatry and Behavioral Sciences in the Johns Hopkins School of Medicine in 2008.  During this time she contributed to numerous studies on the genetic epidemiology of bipolar disorder, depression, postpartum depression and suicidal behavior.  In 2012 Dr. Mahon was awarded a K01 Mentored Research Scientist Development Award from NIMH to investigate neuroimaging and genetic biomarkers of lithium response in bipolar disorder.  Dr. Mahon’s research aims to elucidate neurobiology and epidemiology of mood disorders, with a focus on illness course and outcomes.

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Titles

  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes

Education

Degrees

  • B.A., Boston University (Massachusetts) (2002)
  • Ph.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (2006)

Additional Training

  • Postdoctoral Fellowship in Psychiatric Genetics, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • Stress Neuroendocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • Advanced Research Institute in Geriatric Mental Health

Research & Publications

Research Summary

Dr. Mahon's research aims to further elucidate the etiology, pathophysiology and trajectory of mood disorders utilizing multidisciplinary approaches combining evidence from fields such as neuroimaging, genetics, epigenetics, and stress neuroendocrinology.

Selected Publications

Mahon PB, Lee DS, Trinh H, Tward D, Miller MI, Younes L, Barta PE, Ratnanather JT. Morphometry of the amygdala in schizophrenia and psychotic bipolar disorder. Schizophr Res. 2015;164(1-3):199-202.

Mahon PB, Zandi PP, Potash JB, Nestadt G, Wand GS. Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults. Psychopharmacology. 2013;227(2):231-41.

Mahon PB, Eldridge H, Crocker B, Notes L, Gindes H, Postell E, King S, Potash JB, Ratnanather JT, Barta PE. An MRI study of amygdala in schizophrenia and psychotic bipolar disorder. Schizophr Res. 2012;138(2-3):188-91.

Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D; NIMH Genetics Initiative Bipolar Disorder Consortium; BiGS Consortium, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB. Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am J Psychiatry. 2009;166(11):1229-37.

Dao DT*, Mahon PB*, Cai X, Kovacsics CE, Blackwell RA, Arad M, Shi J, Zandi PP, O'Donnell P, Bipolar Genome Study (BiGS) Consortium, Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, Levinson DF, Thompson SM, Potash JB, Gould TD. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatry. 2010;68(9):801-10. *Joint first authors

Activities & Honors

Honors

  • NIMH K01 Mentored Research Scientist Development Award
  • Johns Hopkins Provost Catalyst Award
  • The Morton Kramer Award for the Application of Biostatistics and Epidemiology in Research on the Prevention and Control of Mental Disorders, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health
  • NIMH Predoctoral Fellowship in Psychiatric Epidemiology

Memberships

  • National Network of Depression Centers
  • International Society of Psychiatric Genetics
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