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Eric Hutton Raabe, M.D., Ph.D.

Photo of Dr. Eric Hutton Raabe, M.D., Ph.D.

Assistant Professor of Oncology

Male

Languages: English, French

Expertise: Brain Cancer, Medical Oncology, Pediatric Oncology

Research Interests: cancer stem cells; cancer metabolism; pediatric brain tumors

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Locations

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-287-6997

1800 Orleans St.
Bloomberg Children's Center
Baltimore, MD 21287 map
Phone: 410-614-5055

Background

Eric Raabe, M.D., Ph.D., is an assistant professor of oncology and an instructor of pathology at Johns Hopkins School of Medicine. 

Dr. Raabe majored in neural science at Brown University and received his M.D. and Ph.D. from the University of Cincinnati College of Medicine. He completed his pediatric internship and residency at Children’s Hospital of Philadelphia.

After spending a year working in Africa as part of the Baylor International Pediatric AIDS Initiative, Dr. Raabe joined Johns Hopkins as a pediatric oncology fellow. Working in the laboratory of Charles Eberhart in Neuropathology, Dr. Raabe established a human neural stem cell system to create genetically accurate models of pediatric brain tumors.

With an interest in neuro-oncology, Dr. Raabe see patients in the pediatric oncology outpatient clinic at Johns Hopkins.

He continues his research in the new Smith Building of the Wilmer Eye Institute in the Neuropathology Division, in collaboration with Charles Eberhart.

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Titles

  • Assistant Professor of Oncology
  • Instructor of Pathology

Departments / Divisions

Education

Degrees

  • MD, University of Cincinnati College of Medicine (2003)

Residencies

  • Children's Hospital of Philadelphia / Pediatrics (2006)

Fellowships

  • Johns Hopkins University School of Medicine / Pediatric Oncology (2011)

Board Certifications

  • American Board of Pediatrics / Pediatric Hematology-Oncology (2016)
  • American Board of Pediatrics / Pediatrics (2008)

Research & Publications

Research Summary

Dr. Raabe’s research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor prognosis brain tumors. Dr. Raabe’s expertise is in stem cell biology, developmental biology and pre-clinical therapeutics. He has generated one of a handful of human diffuse intrinsic pontine glioma cell lines that form xenografts with high fidelity to the primary tumor and retain the H3F3A K27M mutation. He has expertise in targeting stem cell factors in aggressive brain tumors in vivo and in vitro. Dr. Raabe has developed normal human neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors.

Lab

Dr. Raabe currently has a research group composed of research assistants, graduate students, and post-doctoral fellows. He continues to work closely with Dr. Charles Eberhart, who is a neuro-pathologist and core collaborator.

Selected Publications

Raabe, E.H., Lim, K.S., Kim, JM., Meeker, A., Mao, XG., Nikkhah, G., Macizczyk, J., Kahlert, U., Jain, D., Bar, E., Cohen, KJ, Eberhart CG. "BRAF Activation Induces Transformation and then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model." Clinical Cancer Research, (2011) Jun 1;17(11):3590-9.

Raabe, E.H., Eberhart, C.G. "Methylome Alterations ‘Mark' New Therapeutic Opportunities in Glioblastoma. Cancer Cell. (2012) October 16; 22(4): 417-8.

Mao, XG, Hütt-Cabezas, M, Orr, BA, Weingart, M, Taylor I, Rajan K, OdiaY, Kahlert U, Maciaczyk J, NikkhahG, Eberhart CG, Raabe EH. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumor formation by enacting a pro-invasive genetic program. Oncotarget. 2013 Jul;4(7):1050-64. PMCID 3759665

Raabe EH, Kieran MW, Cohen KJ. New Strategies in Pediatric Gliomas: Molecular Advances in Pediatric Low-Grade Gliomas as a Model. Clin Cancer Res. 2013 Jul 23.

Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG. A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol. 2013 Sep 11.

Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger P, Eberhart CG, Rodriguez F, Raabe E, Warren KE, Quezado M. Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol. 2013 Sep;37(9):1357-64. PMCID 3787318

Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH*, Rodriguez FJ*. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol. 2013 Nov 6. *Co-corresponding author.

Activities & Honors

Honors

  • Alpha Omega Alpha, University of Cincinnati College of Medicine, 2002
  • Award Winner, St. Baldrick’s Fellowship, 2008
  • Francis Schwentker Award for Excellence in Research by Pediatrics House Staff and Fellows, Johns Hopkins Hospital, 2011

Memberships

  • American Association for Cancer Research, 2008
  • Children's Oncology Group, 2013
  • Sigma Xi, 1993
  • Society for Neuro-oncology, 2012

Videos & Media

Lectures and Presentations

  • Francis Schwentker Address
    Pediatrics Grand Round , Baltimore, MD (05/01/2011)
    Johns Hopkins Children's Center

Recent News Articles and Media Coverage

Common Genetic Pathway Could be Conduit to Pediatric Tumor Treatment, 11/6/13

Going After the Big Bad Tumor 6/11/13

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