Dr. Raabe’s research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor prognosis brain tumors. Dr. Raabe’s expertise is in stem cell biology, developmental biology and pre-clinical therapeutics. He has generated one of a handful of human diffuse intrinsic pontine glioma cell lines that form xenografts with high fidelity to the primary tumor and retain the H3F3A K27M mutation. He has expertise in targeting stem cell factors in aggressive brain tumors in vivo and in vitro. Dr. Raabe has developed normal human neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors.
Raabe, E.H., Lim, K.S., Kim, JM., Meeker, A., Mao, XG., Nikkhah, G., Macizczyk, J., Kahlert, U., Jain, D., Bar, E., Cohen, KJ, Eberhart CG. “BRAF Activation Induces Transformation and then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model.” Clinical Cancer Research, (2011) Jun 1;17(11):3590-9.
Raabe, E.H., Eberhart, C.G. “Methylome Alterations ‘Mark’ New Therapeutic Opportunities in Glioblastoma. Cancer Cell. (2012) October 16; 22(4): 417-8.
Mao, XG, Hütt-Cabezas, M, Orr, BA, Weingart, M, Taylor I, Rajan K, OdiaY, Kahlert U, Maciaczyk J, NikkhahG, Eberhart CG, Raabe EH. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumor formation by enacting a pro-invasive genetic program. Oncotarget. 2013 Jul;4(7):1050-64. PMCID 3759665
Raabe EH, Kieran MW, Cohen KJ. New Strategies in Pediatric Gliomas: Molecular Advances in Pediatric Low-Grade Gliomas as a Model. Clin Cancer Res. 2013 Jul 23.
Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG. A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol. 2013 Sep 11.
Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger P, Eberhart CG, Rodriguez F, Raabe E, Warren KE, Quezado M. Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol. 2013 Sep;37(9):1357-64. PMCID 3787318
Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH*, Rodriguez FJ*. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol. 2013 Nov 6. *Co-corresponding author.
Dr. Raabe currently has a research group composed of research assistants, graduate students, and post-doctoral fellows. He continues to work closely with Dr. Charles Eberhart, who is a neuro-pathologist and core collaborator.