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Photo of Dr. Eric Raabe

Eric Hutton Raabe, M.D., Ph.D.

Assistant Professor of Oncology

Male

Appointment Phone

443-287-6997

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Assistant Professor of Oncology
  • Instructor of Pathology

Centers & Institutes

Departments

  • Oncology - Pediatric Oncology
  • Pathology - Neuropathology

Locations

The Johns Hopkins Hospital

Appointment Phone: 443-287-6997

600 N. Wolfe Street
Charlotte R. Bloomberg Childrens Center
Baltimore, MD 21287 map
Phone: 410-614-5055

Expertise

Brain Cancer, Medical Oncology, Pediatric Oncology

Research Interests

cancer stem cells; cancer metabolism; pediatric brain tumors

    Additional Information

  • Education +
    • Sc.B., Brown University (Rhode Island) (1993)
    • Ph.D., University of Cincinnati College of Medicine - Cincinnati (Ohio) (2002)
    • M.D., University of Cincinnati College of Medicine - Cincinnati (Ohio) (2003)
  • Research & Publications +

    Research Summary

    Dr. Raabe’s research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor prognosis brain tumors. Dr. Raabe’s expertise is in stem cell biology, developmental biology and pre-clinical therapeutics. He has generated one of a handful of human diffuse intrinsic pontine glioma cell lines that form xenografts with high fidelity to the primary tumor and retain the H3F3A K27M mutation. He has expertise in targeting stem cell factors in aggressive brain tumors in vivo and in vitro. Dr. Raabe has developed normal human neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors.

    Lab:

    Dr. Raabe currently has a research group composed of research assistants, graduate students, and post-doctoral fellows. He continues to work closely with Dr. Charles Eberhart, who is a neuro-pathologist and core collaborator.

    Selected Publications

    Raabe, E.H., Lim, K.S., Kim, JM., Meeker, A., Mao, XG., Nikkhah, G., Macizczyk, J., Kahlert, U., Jain, D., Bar, E., Cohen, KJ, Eberhart CG. "BRAF Activation Induces Transformation and then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model." Clinical Cancer Research, (2011) Jun 1;17(11):3590-9.

    Raabe, E.H., Eberhart, C.G. "Methylome Alterations ‘Mark’ New Therapeutic Opportunities in Glioblastoma. Cancer Cell. (2012) October 16; 22(4): 417-8.

    Mao, XG, Hütt-Cabezas, M, Orr, BA, Weingart, M, Taylor I, Rajan K, OdiaY, Kahlert U, Maciaczyk J, NikkhahG, Eberhart CG, Raabe EH. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumor formation by enacting a pro-invasive genetic program. Oncotarget. 2013 Jul;4(7):1050-64. PMCID 3759665

    Raabe EH, Kieran MW, Cohen KJ. New Strategies in Pediatric Gliomas: Molecular Advances in Pediatric Low-Grade Gliomas as a Model. Clin Cancer Res. 2013 Jul 23.

    Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG. A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol. 2013 Sep 11.

    Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger P, Eberhart CG, Rodriguez F, Raabe E, Warren KE, Quezado M. Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol. 2013 Sep;37(9):1357-64. PMCID 3787318

    Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH*, Rodriguez FJ*. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol. 2013 Nov 6. *Co-corresponding author.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Alpha Omega Alpha, University of Cincinnati College of Medicine, 2002
    • Award Winner, St. Baldrick’s Fellowship, 2008
    • Francis Schwentker Award for Excellence in Research by Pediatrics House Staff and Fellows, Johns Hopkins Hospital, 2011

    Memberships

    • Sigma Xi, 1993
    • American Association for Cancer Research, 2008
    • Society for Neuro-oncology, 2012
    • Children's Oncology Group, 2013
  • Videos & Media +

    Lectures and Presentations

    Francis Schwentker Address
    Pediatrics Grand Round , Baltimore, MD (05/01/2011)
    Johns Hopkins Children's Center

    Recent News Articles & Media Coverage

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