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Photo of Dr. Eric Raabe

Eric Hutton Raabe, MD PhD

Assistant Professor of Oncology
Male
Appointment Phone

443-287-6997

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Assistant Professor of Oncology
  • Instructor of Pathology

Centers & Institutes

  • Pediatric Oncology Program
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Brain Cancer, Medical Oncology, Pediatric Oncology

Research Interests

pediatric brain tumors; cancer metabolism; cancer stem cells

Languages

  • English
  • French

Memberships

1993 - current                        Sigma Xi

2008 - current                        American Association for Cancer Research

2012-  current                        Society for Neuro-oncology

2013-  current                        Children’s Oncology Group

Additional Resources +
  • Education +

    Training

    • University of Cincinnati College of Medicine Office of Student Affairs and Admissions (Cincinnati OH) (2003)
    • University of Cincinnati College of Medicine Office of Student Affairs and Admissions (Cincinnati OH) (2002)

    Residencies

    • Children's Hospital of Philadelphia / Pediatrics (Philadelphia PA) (2006)

    Fellowships

    • Johns Hopkins University School of Medicine / Pediatric Oncology (Baltimore MD) (2011)
    • National Institutes of Health - Credentialing Services Section / Pediatric Oncology (Bethesda MD) (2011)

    Certifications

    • American Board of Pediatrics / Pediatrics (2008)
  • Research & Publications +

    Research Summary

    Dr. Raabe’s research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor prognosis brain tumors. Dr. Raabe’s expertise is in stem cell biology, developmental biology and pre-clinical therapeutics. He has generated one of a handful of human diffuse intrinsic pontine glioma cell lines that form xenografts with high fidelity to the primary tumor and retain the H3F3A K27M mutation. He has expertise in targeting stem cell factors in aggressive brain tumors in vivo and in vitro. Dr. Raabe has developed normal human neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors.

    Selected Publications

    Raabe, E.H., Lim, K.S., Kim, JM., Meeker, A., Mao, XG., Nikkhah, G., Macizczyk, J., Kahlert, U., Jain, D., Bar, E., Cohen, KJ, Eberhart CG. “BRAF Activation Induces Transformation and then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model.” Clinical Cancer Research, (2011) Jun 1;17(11):3590-9.

    Raabe, E.H., Eberhart, C.G. “Methylome Alterations ‘Mark’ New Therapeutic Opportunities in Glioblastoma. Cancer Cell. (2012) October 16; 22(4): 417-8.

    Mao, XG, Hütt-Cabezas, M, Orr, BA, Weingart, M, Taylor I, Rajan K, OdiaY, Kahlert U, Maciaczyk J, NikkhahG, Eberhart CG, Raabe EH. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumor formation by enacting a pro-invasive genetic program. Oncotarget. 2013 Jul;4(7):1050-64. PMCID 3759665

    Raabe EH, Kieran MW, Cohen KJ. New Strategies in Pediatric Gliomas: Molecular Advances in Pediatric Low-Grade Gliomas as a Model. Clin Cancer Res. 2013 Jul 23.

    Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG. A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol. 2013 Sep 11.

    Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger P, Eberhart CG, Rodriguez F, Raabe E, Warren KE, Quezado M. Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol. 2013 Sep;37(9):1357-64. PMCID 3787318

    Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH*, Rodriguez FJ*. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol. 2013 Nov 6. *Co-corresponding author.

    Lab

    Dr. Raabe currently has a research group composed of research assistants, graduate students, and post-doctoral fellows. He continues to work closely with Dr. Charles Eberhart, who is a neuro-pathologist and core collaborator.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    October 2002             Alpha Omega Alpha, University of Cincinnati College of Medicine

    July 2008                   St. Baldrick’s Fellowship award winner

    May 2011                   Francis Schwentker Award for Excellence in Research by Pediatrics House Staff and Fellows at Johns Hopkins

  • Videos & Media +
  • Events +

    Grand Rounds Lectures

     

    May 2011                   Francis Schwentker Address at Pediatrics Grand Rounds Johns Hopkins Children's Center

  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Charlotte R. Bloomberg Childrens Center
    11th Floor - Pediatric Oncology
    Baltimore, MD 21287
    Phone: 410-614-5055
    Appointment Phone: 443-287-6997
    Location Map

    Department/Division

    • Oncology - Pediatric Oncology

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