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School of Medicine
Alexander Holliday Hoon, Jr, M.D., M.P.H.
Associate Professor of Pediatrics
Research Interests: Cerebral palsy, Diffusion tensor imaging, Neuroimaging techniques, Cause and treatment in cerebral palsy
Dr. Alexander Hoon is an associate professor of pediatrics at the Johns Hopkins University School of Medicine. He also serves as the director of the Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine and medical director of the Carter Center for Holoprosencephaly and Related Disorders at Kennedy Krieger Institute.
Dr. Hoon received a bachelor of science from Davidson College in 1974, and a medical degree from the University of Pittsburgh in 1978. After a pediatric residency at Kosair-Children's Hospital in Louisville, he completed a neonatology fellowship at British Columbia Children's Hospital and a one-year fellowship in medical genetics at the Affiliated Hospitals in Vancouver, Canada. In 1988, he came to Baltimore where he completed a fellowship in neurodevelopmental disabilities at Kennedy Krieger Institute, and obtained a master's of public health at Johns Hopkins School of Hygiene and Public Health. He joined the Kennedy Krieger faculty in 1990.
Using his training in neonatology, genetics, neurodevelopmental disabilities and public health and working with collaborative research teams, Dr. Hoon addresses questions of cause and treatment in cerebral palsy. His current research uses advanced neuroimaging techniques, including diffusion tensor imaging (DTI), in the Kennedy Krieger Institute Kirby Research Center for Functional Brain Imaging, to more precisely characterize brain injury.
Dr. Hoon is a member of the American Academy of Pediatrics, the American Society of Human Genetics, the American Academy for Cerebral Palsy and Developmental Medicine, the Society for Developmental Pediatrics and the Kennedy Fellows Association. He was awarded the 2001 Kennedy Krieger Institute William J. Hersey Prize for exceptional commitment to children with disabilities.
- Associate Professor of Pediatrics
Departments / Divisions
- Pediatrics - Kennedy Krieger Institute
- MD, University of Pittsburgh (1978)
- Kosair Children's Hospital (Alliant Health System) / Pediatrics (1981)
- Children's Women's Health Center of British Columbia / Genetics (1985)
- Grace Hospital / Genetics (1986)
- Kennedy Krieger Institute / Developmental and Behavioral Pediatrics (1990)
- American Board of Pediatrics / Neonatal-Perinatal Medicine (1987)
- American Board of Pediatrics / Neurodevelopmental Disabilities (2001, 2012)
- American Board of Pediatrics / Pediatrics (1982)
Research & Publications
Cerebral palsy, the most common form of chronic motor disability beginning in childhood, is often related to events before birth affecting brain development. Modern imaging techniques, including conventional brain MRI and diffusion tensor imaging (DTI), can now be used to establish cause and refine treatment for children, adolescents and adults with cerebral palsy.
Dr. Hoon, utilizing training in neonatology, genetics, neurodevelopmental disabilities and public health and working with collaborative research teams, addresses questions of cause and treatment in cerebral palsy.
His past research addressed causal factors, quantification of the severity of functional impairment, and treatment with oral medications. Current research at the Kennedy Krieger Institute Kirby Research Center for Functional Brain Imaging uses advanced neuroimaging techniques, including DTI to more precisely characterize brain injury. These imaging modalities will allow researchers studying rehabilitative interventions to assign children with cerebral palsy to cohorts with comparable levels of injury.
Hoon AH, Stashinko EE. "Neuroimaging: connecting the pixels." Dev Med Child Neurol. 2011 Jun;53(6): 482.
Hoon AH, Stashinko EE, Nagae LM, Lin DDM, Keller J, Bastian A, et al "Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways." Dev Med Child Neurol. 2009 Sep;51(9): 697-704.
Johnston MV, Hoon AH. "Cerebral palsy." Neuromolecular Med. 2006;8(4): 435-50.
Hoon AH. "Neuroimaging in cerebral palsy: Patterns of brain dysgenesis and injury." J Child Neurol. 2005 Dec;20(12): 936-9.
Accardo J, Kammann H, Hoon AH. "Neuroimaging in cerebral palsy". J Pediatrics. 2004 Aug;145(2 Suppl), S19-27.
Activities & Honors
- William J. Hersey Prize, ennedy Krieger Institute, 2001
- American Academy of Pediatrics
- American Society of Human Genetics
- American Academy for Cerebral Palsy and Developmental Medicine
- Society for Developmental Pediatrics
- Kennedy Fellows Association