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Photo of Dr. Ashley Evan Ross, MD PhD

Ashley Evan Ross, MD PhD

Assistant Professor of Urology

See Research on Pubmed

Primary Location

The Johns Hopkins Hospital

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  • Assistant Professor of Urology
  • Assistant Professor of Oncology
  • Assistant Professor of Pathology

Centers & Institutes

  • James Buchanan Brady Urological Institute
  • Sidney Kimmel Comprehensive Cancer Center



Research Interests

Prostate cancer; Prostate carcinogenesis; Prostate cryotherapy; Active surveillance of prostate cancer


Dr. Ashley Evan Ross is an assistant professor of urology, oncology and pathology at the Johns Hopkins School of Medicine. His clinical practice focuses on prostate cancer and prostatic diseases.

He has expertise in open and robotic treatment of prostate cancer as well as in focal and salvage prostate cryotherapy and in the active surveillance of prostate cancer. Additionally, Dr. Ross has experience in the treatment of benign prostatic hyperplasia through the use of transurethral resection, laser photo-vaporization and open surgical approaches. As an active member of the Sidney Kimmel Comprehensive Cancer Center, Dr. Ross offers multidisciplinary approaches to the treatment of prostate cancer.

Dr. Ross received his undergraduate degree in biochemistry from the University of Maryland. He earned his graduate and medical degrees from the Johns Hopkins School of Medicine. Dr. Ross joined the faculty in 2012 after completing his general surgery and urology residency and fellowship at Johns Hopkins.

Dr. Ross’s research focuses on prostate carcinogenesis. His laboratory investigates molecular mechanisms that drive prostate cancer and is developing and testing novel targeted therapies for this aggressive disease. Dr. Ross is known for his discovery of how to use Relaxin 1 (RLXN1) as a tissue/urine/blood-based biomarker of high-grade prostate cancer.

Dr. Ross has been recognized with numerous awards and honors. He served as the chief resident in the Department of Urology’s residency program at Johns Hopkins. Most recently, he was recognized with a first prize for a paper presentation at the Baltimore-Washington-West Virginia Urology Resident Day. He is a member of the American Urologic Association.


  • English


Alpha Omega Alpha (AOA), 2006

American Urologic Association, 2008

Additional Resources +
  • Education +


    • Johns Hopkins University School of Medicine ( Baltimore MD ) (2006)


    • The Johns Hopkins Hospital/Urology ( Baltimore MD ) (2012)
  • Research & Publications +

    Research Summary

    Dr. Ross is a fully trained scientist and an expert on prostate carcinogenesis. His research examines the molecular mechanisms that drive prostate cancer, and he develops and tests targeted therapies for treating prostate cancer. Dr. Ross patented his discovery of how to use Relaxin 1 (RLXN1) as a tissue/urine/blood-based biomarker of high-grade prostate cancer.

    Dr. Ross’ research focuses on diagnosing high-risk prostate cancer patients. Recent studies used a newly developed clinical test based on the specific pattern of gene expression from the primary tumor to help predict which men with an elevated PSA after radical prostatectomy will go on to develop metastatic disease.

    He and his colleagues also analyzed data regarding high-risk prostate cancer patients and identified a new subgroup of men with localized prostate cancer: men at very high risk of having metastasis and death from prostate cancer after prostatectomy.

    By better identifying patients who are high risk for metastatic cancer, doctors can offer more effective, targeted prostate cancer treatment.

    Selected Publications View all on PubMed

    1. Sundi D, Wang VM, Pierorazio PM, Han M, Bivalacqua TJ, Ball MW, Antonarakis ES, Partin AW, Schaeffer EM, Ross AE. “Very-high-risk localized prostate cancer: definition and outcomes.” Prostate Cancer and Prostatic Disease. 2013 Nov 5. doi: 10.1038/pcan.2013.46. [Epub ahead of print].
    2. Ross AE, Feng FY, Ghadessi M, Erho N, Crisan A, Buerki C, Sundi D, Mitra AP, Vergara IA, Thompson DJ, Triche TJ, Davicioni E, Bergstralh EJ, Jenkins RB, Karnes RJ, Schaeffer EM. “A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy.” Prostate Cancer and Prostatic Disease. 2013 Oct 22. doi: 10.1038/pcan.2013.49. [Epub ahead of print].
    3. Ciolino JB, Stefanescu CF, Ross AE, Salvador-Culla B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS. “In vivo performance of a drug-eluting contact lens to treat glaucoma for a month.” Biomaterials. 2014 Jan;35(1):432-9. doi: 10.1016/j.biomaterials.2013.09.032. Epub 2013 Oct 4.
    4. Pierorazio PM, Gorin MA, Ross AE, Feng Z, Trock BJ, Schaeffer EM, Han M, Epstein JI, Partin AW, Walsh PC, Bivalacqua TJ. “Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience.” Prostate. 2013 Nov;73(15):1673-80. doi: 10.1002/pros.22702. Epub 2013 Sep 9.
    5. Fang H, Pajski ML, Ross AE, Venton BJ. “Quantitation of dopamine, serotonin and adenosine content in a tissue punch from a brain slice using capillary electrophoresis with fast-scan cyclic voltammetry detection.” Analytical methods: advancing methods and applications. 2013;5(11):2704-2711.


    Dr. Ross’ laboratory investigates the molecular mechanisms that drive prostate cancer. He is developing and testing novel targeted therapies for this aggressive disease. Additionally, researchers in his lab are developing tests to guide the best diagnostic and treatment selection for each individual prostate cancer patient.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    Chief Resident, Department of Urology, Johns Hopkins Medical Institution, 2010-2012

    First Prize, Paper Presentation, Baltimore-Washington-West Virginia Urology Resident Day, 2012

    Honorable Mention, Johns Hopkins University Seventh Annual Prostate Research Day: “Development of simple genomic predictors to distinguish indolent and lethal prostate cancer,” 2012

    Honorable Mention, Johns Hopkins University Fifth Annual Prostate Research Day, "Defining the Molecular Basis of High Risk, Lethal Prostate Cancer," 2010

    Johns Hopkins Department of Medicine Osler Medical Housestaff Teaching Award, 2009

    Johns Hopkins Hospital Catch A Shining Star Annual Award Winner, 2008

    Johns Hopkins Bayview Medical Center Shining Star Award, 2008

    Johns Hopkins Bayview Medical Center Shining Star Award, 2007

    Surgery Clerkship Teaching Award, Outstanding Junior Resident Teacher, Johns Hopkins Hospital, 2007

    Surgical Intern of the Year, Johns Hopkins Hospital, Department of Surgery, 2006

    Academy of Achievement Award, 2006

    Pathology Young Investigator’s Award for Excellence in Clinical Research, 2005

    Medical Scientist Training Program Fellowship, 1997

    Howard Hughes Medical Institute Undergraduate Research Fellowship, 1996

    University of Maryland Senior Summer Scholarship, 1996

    Junior Merck Index Award, 1996

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    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410 955 4494
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    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Phone: 410 955 4494
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    • Urology

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