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Trinity Jude Bivalacqua, M.D., Ph.D.

Photo of Dr. Trinity Jude Bivalacqua, M.D., Ph.D.

Director of Urologic Oncology

Associate Professor of Urology

Male

Expertise: Benign Prostatic Hyperplasia (BPH), Bladder Cancer, Erectile Dysfunction, Genitourinary Sarcoma, Kidney Cancer, Penile Cancer, Prostate Cancer, Robotic Prostatectomy, Urethral Cancer, Urinary Tract Cancer, Urological Oncology, Urology ...read more

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-6070

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center
Appointment Phone: 410-955-6070

601 N. Caroline St.
Baltimore, MD 21287 map

Background

Trinity J. Bivalacqua, M.D., Ph.D., is the R. Christian B. Evensen Professor of Urology and Oncology and Director of Urologic Oncology at the James Buchanan Brady Urologic Institute.  He was born in New Orleans, Louisiana and graduated from Tulane University with undergraduate, graduate and medical degrees. He joined the faculty after completing his General Surgery and Urology training at Johns Hopkins Hospital. He also completed an American Urological Association (AUA) Foundation Post-Doctoral Fellowship from the AUA Care Foundation.

Dr. Bivalacqua has an active clinical practice in Urologic Oncology and Sexual Dysfunction. As a member of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Dr. Bivalacqua participates in multidisciplinary approaches to the treatment of a variety of genitourinary cancers. He has a special interest in cancers of the prostate and bladder with an emphasis on organ sparing therapies, minimally invasive techniques (nerve-sparing robotic assisted laparoscopic radical prostatectomy) and robotic-assisted laparoscopic radical cystectomy) and orthotopic bladder substitution (neobladder). Although he has a busy surgical practice, he maintains an active research portfolio in order to improve outcomes of cancer patients. A major focus of his research lab is development of pre-clinical models of urothelial carcinoma to test systemic and intravesical immunotherapies and nano-particular based chemotherapies. Also, he heads the tissue-engineering lab which focuses on regenerative approaches to enhance autonomic nerve function and development of tissue-engineered urinary tissue with the ultimate goal of production of a neo-urinary conduit and bladder.

Dr. Bivalacqua's basic, translational and clinical research is funded by peer-reviewed awards and he has recently been acknowledged for his accomplishments in research with several grants including a Career Development Award from the National Institute of Health (NIH), Greenberg Bladder Cancer Institute, and the AUA "Rising Star" Award. He also serves on the Scientific Advisory Board of the Bladder Cancer Advocacy Network (BCAN) and a member of the AUA Leadership Program. 

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Titles

  • Director of Urologic Oncology
  • Associate Professor of Urology
  • Associate Professor of Oncology
  • Associate Professor of Surgery

Departments / Divisions

Education

Degrees

  • MD PhD, Tulane University School of Medicine (2004)

Residencies

  • Johns Hopkins University School of Medicine / Urology (2009)

Board Certifications

  • American Board of Urology / Urology (2012)

Research & Publications

Research Summary

Dr. Bivalacqua maintains an active research portfolio in order to improve the care of cancer patients. A major focus of his research lab is to develop novel molecular-based targeted therapies for bladder cancer and preservation of erectile function in prostate cancer patients undergoing radical prostatectomy using novel agents.

Dr. Bivalacqua's basic, translational and clinical research is funded by peer-reviewed awards and he has recently been acknowledged for his accomplishments in research with several grants including a Career Development Award from the National Institute of Health (NIH), the Patrick C. Walsh Prostate Cancer Research Fund, and the American Urological Association (AUA) "Rising Star” Award. He serves as principal investigator for clinical trials in both prostate and bladder cancer including the only tissue engineered bladder cancer clinical trial in this country.

Clinical Trials

Improving Sensitivity of Urine Cytology for Bladder Cancer

Incontinent Urinary Diversion Using an Autologous Neo-Urinary Conduit

Erythropoietin to Enhance Erection Recovery in Men Following Radical Prostatectomy (EPO)

Intravesical Administration of INSTILADRIN (rAd-IFN With Syn3) in Patients With Bladder Cancer

Selected Publications

View all on Pubmed

Sundi D, Wang V, Pierorazio PM, Han M, Partin AW, Tran PT, Ross AE, Bivalacqua TJ. "Identification of men with the highest risk of early disease recurrence after radical prostatectomy." Prostate. 2014 Jan 22. doi: 10.1002/pros.22780.

Musicki B, Bivalacqua TJ, Champion HC, Burnett AL. "Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis." J Sex Med. 2014 Feb;11(2):424-30. doi: 10.1111/jsm.12391.

Kates M, Gorin MA, Deibert CM, Pierorazio PM, Schoenberg MP, McKiernan JM, Bivalacqua TJ. "In-hospital death and hospital-acquired complications among patients undergoing partial cystectomy for bladder cancer in the United States." Urol Oncol. 2014 Jan;32(1):53.e9-53.e14. doi: 10.1016/j.urolonc.2013.08.024.

Sundi D, Wang VM, Pierorazio PM, Han M, Bivalacqua TJ, Ball MW, Antonarakis ES, Partin AW, Schaeffer EM, Ross AE. "Very-high-risk localized prostate cancer: definition and outcomes." Prostate Cancer Prostatic Dis. 2013 Nov 5. doi: 10.1038/pcan.2013.46.

Chalfin HJ, Gurda GT, Hammers HJ, Netto GJ, Bivalacqua TJ. "Renal cell carcinoma presenting with brain metastasis from a 1.6 cm primary tumor." Can J Urol. 2013 Oct;20(5):6965-7.

Activities & Honors

Honors

  • 2nd Prize Resident Essay Contest: Laboratory Science, America Urological Association, 2008
  • Best Poster, American Urological Association (AUA) Annual Meeting, 2011
  • Alpha Omega Alpha, Johns Hopkins University, 2007
  • Outstanding Surgical Intern, Johns Hopkins University, 2004
  • 1st Prize Resident Essay Contest: Laboratory Science, Mid-Atlantic Section AUA, 2007
  • Arnold M Seligman Award for Most Outstanding Surgical Resident, Sinai Hospital of Baltimore, 2004
  • John T. Halsey Award, Tulane School of Medicine, 2004
  • Joseph Hume Memorial Award, Tulane School of Medicine, 2004
  • Jorgen U. Schlegel Award for Excellence in Research, Tulane School of Medicine, 2001
  • Foundation Rising Star in Urology Research Award, American Urological Association (AUA) , 2012
  • Young Investigator Award , Society of Basic Urologic Research (SBUR), 2010
  • Jack Lapides Neurourology Essay Contest Grand Prize Winner, 2008
  • Cook Urology Travel Award, American Society of Andrology, 2008
  • Trainee Award, American Society of Andrology, 2008
  • Outstanding Graduate, AUA Foundation, 2008
  • Young Investigator Award , AUA Research Forum, 2008
  • Astellas USA Foundation MD/PhD Fellowship, American Urological Association Foundation , 2007 - 2008
  • Best Basic Science Abstract, Sexual Medicine Society of North America, Inc., 2007
  • Zorgniotti-Newman Prize (Co-author): Best Clinical Research in Sexual Medicine, 2006
  • Best Basic Science Abstract, Sexual Medicine Society of North America, Inc., 2005
  • Student Recognition Award, American Federation for Medical Research , 2004
  • Yamanouchi Best Abstract Prize: Impotence, AUA, 2004
  • Best Basic Science Abstract: Sexual Medicine Society of North America, 2003
  • Jean François Ginestíe Prize: Best Paper on Basic Science of Sexual Medicine, 2002
  • 3rd Prize Montague Boyd Essay Contest, Southeastern Section AUA, 2001
  • Basic Research Award in Integrated Biology, Tulane Health Research Day, 2001
  • 1st Prize Essay Contest, Society for the Study of Impotence, 2000
  • Thomas S.K. Change Trainee Award, American Society of Andrology, 1999

Memberships

  • Alpha Omega Alpha (AOA)
  • American Society of Andrology
  • American Urologic Association (AUA)
  • Endourological Society
  • International Society of Sexual Medicine
  • Sexual Medicine Society of North America, Inc.
  • Society for Basic Urologic Research (SBUR)
  • Society of Urologic Oncology (SUO)

Videos & Media

Trinity J. Bivalacqua, M.D, Ph.D, Johns Hopkins Medicine, Urology

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